6BJC


Conserved Protein Domain Family
TPX2_importin
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pfam12214: TPX2_importin (this model, PSSM-Id:371966 is obsolete and has been replaced by 463495)
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Cell cycle regulated microtubule associated protein
This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with pfam06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localization signal in this domain.
Links
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Statistics
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PSSM-Id: 371966
Aligned: 36 rows
Threshold Bit Score: 108.517
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BJC_T       367 PQTPVLQTKHRARAVTCKSTAELEAEeLEKLQqyKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERES 446 human
KRH04063      91 PREPDLRTARRAHRIRPKNVGEAEHV-TVAAP--KFKARPLNRKILEAPSMLPPKRSTPRLPEFQEFHLKTFERAMQHTS 167 soybean
KRH77444     251 PREPDLETAHRAQRIRPKIAAEAEVV-TVAAP--IFRARPLNRKILNAPSLPLPKRSTPRLPEFQEFHLKTQERAMQHTS 327 soybean
ERN19493     318 PREPELETAQRARRIMIKKNSDAGEGmLLMAP--KFKARPLNRKIFEAPSVPLPQKSIPRVPEFREFHLKTTERAIQHAA 395 Amborella trich...
EEF51033     248 PREPDLETAHRAHRMRPKNNTEVEHV-TVAAQ--RFKARPLNRKILEAPSLPLPKKSTPKLPEFQEFHLKTLERAMQHAF 324 castor bean
XP_002303544 259 PREPDLETAHRAQRTRPKDSIEQQHM-TAPAR--RFKARPLNRKILEAPSLPLPKKSTPKLPEFQEFHLKTLERAMQHTS 335 black cottonwood
Q4V3B0       249 PQEPDFATSHRANRIRHKNDAKLEQD-STSVY--RFKARPLNRKIFEAPSLPIRKNSTPKLPEFQEFRLKTSERAMQHSS 325 thale cress
NP_001078430 249 PQEPDFATSQRAHRIRHKNDAKLEQE-QPAVY--RFKARPFNRKIFDAPSLPIRKKSTPKLPEFQEFHLKTSERAMQHSS 325 thale cress
CBI34799     258 PREPNLETAYRTQRMRSKHHTEVDQV-ALNVH--RFKARPLNRKILEAPSLPLPKKSTPRLPEFQEFHLKTSERARQHTT 334 wine grape
XP_009136255 222 PHGADFVTSQRALRIRQKNDAKLEQD-STAVY--KFKARPLNRKIFDAPSLPIRKKSTPKLTEFQEFHLKTSERAMQHSS 298 field mustard

6BJC_T       447 KKKT-E---------------------------------------------De----HFEFHSRPCPTKILE--DVVGVP 474 human
KRH04063     168 AMSS-Sfhyddsdkgwdkhtsvsa---------lenrikdlrrpaaaaaptNdglgfTHIFKAQPLNKKILPskGNGGVF 237 soybean
KRH77444     328 ATSTsSlhcndsdkdldkhravsa---------qenrirdlrrpsamgapkHdgldfAHSFKARPLNKKILSskGDIGVF 398 soybean
ERN19493     396 AAPSlPshvdsnnvankhkhassnqvgtidlkmschqaphlekhkvvdepkQeqrerIATFKARPLNPKILSskGDIGMF 475 Amborella trich...
EEF51033     325 VVSSsSlqhndseqgldksttvsv---------aeigkresrrpstvdtkkQdgcsaPHVFKARPLNKKIFTskGDIGVF 395 castor bean
XP_002303544 336 SVPSsLfqcndldkgldkpstisv---------aenvktesrrpttmdapkQdgccaTHIFKARPLNKKIFSskGEMGVF 406 black cottonwood
Q4V3B0       326 AVSTsSyqgnnnhkeadkpnrtfp----------dgvnreprrqraidipkDdv--rKDLFKARPLNKKILSsgREIGMF 393 thale cress
NP_001078430 326 AVTTrShaykesdksiitdmld-------------gdnresrrpsgmdiskHdvsegSHVFKARPLNKKILSsrGDMGIF 392 thale cress
CBI34799     335 GSSS-Slhcndpdkglqkpstnsv---------pengnkdlrrpnttdapkQdacetVRTFKARPLNKKIFSskGDIGVF 404 wine grape
XP_009136255 299 QVTKrSnqwnhaykgpdksnitdv---------fdgvsmesrrpsgmdiskHdvsegKHVFKARPLNKKFPD-------- 361 field mustard

6BJC_T       475 EKKVLPITVPKSPA 488 human
KRH04063     238 HNSKQETTVPMEFD 251 soybean
KRH77444     399 RNRKQETTVPMEFN 412 soybean
ERN19493     476 KNCKREATKPTEFS 489 Amborella trichopoda
EEF51033     396 RNSKRETTVPTEFN 409 castor bean
XP_002303544 407 RNSKRETTVPMEFN 420 black cottonwood
Q4V3B0       394 TKSKRETTAPLGFS 407 thale cress
NP_001078430 393 KNSKRETTVPLEFS 406 thale cress
CBI34799     405 RNSKRETTVPLEFN 418 wine grape
XP_009136255 362 KDETDSEMATQEFN 375 field mustard
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