Conserved Protein Domain Family
KN_motif

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pfam12075: KN_motif (this model, PSSM-Id:371886 is obsolete and has been replaced by 432311)
KN motif
This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with pfam00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors.
Statistics
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PSSM-Id: 371886
Aligned: 13 rows
Threshold Bit Score: 43.4879
Created: 1-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014326532         25 PYSVET----PYGFHLDLDFLKYVD--DIEKGNTIK-RVH---IQRRVK 63   southern platyfish
5_pfamImport          1 SYTVET----PYGFHLDLDFLKYVE--ELERGPVAR-RAPsaqLARRPR 42  
1_pfamImport          1 PYCLET----PYGYQLDLDFLKYVD--DIERGNTIK-KLN---IQRKPK 39  
3_pfamImport          1 PFSVNT----PYGYQLDLDFVKYVD--DIERSDTIR-RLR---FNKRP- 38  
10_pfamImport         1 PYSVET----PYGYRLDLDFLKYVD--DIEKGHTLR-RVA---VQRRPR 39  
8_pfamImport          1 -YSVET----PYGFQLDLDFLKYVD--DIQSGQTLR-KVN---VQRKSK 38  
6_pfamImport          1 SYSVET----PYGFLLDLDFLKYVD--DIESGQTLK-KVP---LPRRL- 38  
4_pfamImport          1 PYSVET----PYGFQLDLDFLKYVE--DIESGQGLRsRAP---LPTRRP 40  
9_pfamImport          1 SYSVQT----PYGFQLDLDFLKYVE--EIESGHNLR-RAP---ISSRR- 38  
2_pfamImport          1 AYSVQT----PYGFELDLDFLKYVE--EIESGHSIR-RAN---VHPRR- 38  
FlyBase:CG10249-PC   38 TRSVRScnccPYGYHIDLDFVRYCEalALEKPSEEEqRRR---DRRRSR 83   fruit fly
7_pfamImport          1 -YGLRT----PYGTHLNLDFVKYCE--DLMSGQSFK-RTS---SFRRPR 38  
EDL86619             32 PYSVET----PYGFHLDLDFLKYVE--EIERGPASR-RAPgppHARRPR 73   Norway rat
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