Conserved Protein Domain Family
N-SET
?
pfam11764: N-SET (this model, PSSM-Id:371711 is obsolete and has been replaced by 463344)
COMPASS (Complex proteins associated with Set1p) component N
The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes. This domain promotes trimethylation in conjunction with an RRM domain and is necessary for binding of the Spp1 component of COMPASS into the complex.
Links
?
Statistics
?
PSSM-Id: 371711
Aligned: 80 rows
Threshold Bit Score: 130.87
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
CCF58667      782 YGIAD-LQEYVkDDEDMLILQKLCNMthdtktigpsikteagtkpesDFKPATHSNGLLEYRIWKL-REKQTNV------ 853  Kazachstania ...
ETN58655     1778 MVLYDfLTRGI-DTEDTQYIRQSYDLl--------------------LMDDANNYWLNATHWVDHC-ATDRSFEpalh-- 1833 Anopheles dar...
6_pfamImport    1 GILYKiWEAGL-DVEDMKHLRHVYEEm--------------------LATPGEMGWVNDTHWVPHP-TTHIPTDddv--- 55  
ELK26329     1151 TILYDiWNGGI-DEEDIRFLCVTYERl--------------------LQQDNGMDWLNDTLWVYHP-YILPHGAgaappg 1208 Myotis davidii
XP_001920852 1969 TILYDiWNSGL-DQEDMRLLKSTYEKl--------------------LQDDHGTDWLNDTHWVPHT-ITNIPNP------ 2020 zebrafish
XP_008113606 1644 TILYDiWNSGL-DLEDMKYLRLTYERl--------------------LHEDNSTDWLNDTHWVHHT-ITNIA-------- 1693 green anole
AAH27450      187 TILYDiWNSGL-DSEDMSYLRLTYERl--------------------LQQTSGADWLNDTHWVHH---TITNLTtpk--- 239  human
XP_005921880 1914 TILYDiWNSGL-DGEDLLFLKKTYEKl--------------------LQDDHSSDWLNDTHWVNHTiTNLP--------- 1963 Burton's mout...
XP_007663751 1040 TILYDiWNGGI-DEEDIKFLCITYDRl--------------------LQQDNGMDWLNDTLWVYHP-S------------ 1085 platypus
XP_007255045 1561 TILYDiWNDGI-DEEDIKYLKITYDKl--------------------LQQDNVNDWLNDTLWVHHP-TTSGGSLp----- 1613 Mexican tetra

CCF58667      854 ---R-QTKEWQ--FK-----LNegv--sfDAGLLLNNNlSFKAEGFKKVPDNLKVSYL-PHRRRIHQPLNTVHHHDEATD 919  Kazachstania ...
ETN58655     1834 qalG-GPSAAK--RRkkdkfIDrs----lADIKLHRTG-CARTEGYYKIDALEKAKYK-YHHLKGMTTT----AAGTSSG 1900 Anopheles dar...
6_pfamImport   56 tglS-PTKRGRrkRRqskkdVA-------ADPHAHKTG-CARSEGYYKVNDSTKLI---QRRLMYRQADNTPQPRSKSKY 123 
ELK26329     1209 tgsPhPPSCCPrhPL-----CSakkkkrdDDIPEHVTG-CARSEGFYTIDKKDKIRYLnNTRASTDEPPTDTQ------- 1275 Myotis davidii
XP_001920852 2021 -------RRKK--KT-----AD-------GQLREHVTG-CARSEGYYAISRKEKDVYL-----ELDQPVTLRE------- 2066 zebrafish
XP_008113606 1694 -----NPKRKR--KS--------------SDLREHQTG-CARSEGYYHISKKEKDKYL-DVCPATVQQLDAPDT------ 1744 green anole
AAH27450      240 -rkR-RPQDGP---------------------REHQTG-SARSEGYYPISKKEKDKYL-DVCPVSARQLEGVDTQ----- 289  human
XP_005921880 1964 -----NPRRKK--KN-----TD-------GQLREHVTG-CARSEGYYAISRKEKDVYL-----DLDLPEQVIREVENVDT 2018 Burton's mout...
XP_007663751 1086 ---------TSfsTP-----KKkk---reDGMREHTTG-CARSEGYYKIDKKDKLKYLnNSRAFADEPPADTQ------- 1140 platypus
XP_007255045 1614 -----GLKKKR---------RE-------DGMRDHVTG-CARSEGYYKIDKKDKLKYLiSSRPQFDEPDKDTQ------- 1664 Mexican tetra

CCF58667      920 ERSSTpsnnntkveeslqsESSENVSVVQeiSSSRDNRAINRRFQQDIEAQKaaiGSESELLSLNQ 985  Kazachstania africana CBS 2517
ETN58655     1901 AAANL----------------ELAKAVAKmqGISREARSNQRRLLNAFGA-----STESELLKFNQ 1945 Anopheles darlingi
6_pfamImport  124 SNE----------------SSSTSVVANE---KSRETRHMMRRIASEFG------SDASDLLKYNQ 164 
ELK26329     1276 -------------------GMSIPAQPHAstRAGSERRSEQRRLLSSFTG-----SCDSDLLKFNQ 1317 Myotis davidii
XP_001920852 2067 ---------------------IGDYDTAGsnRVLSERRSEQRRLLSAIGTPA---VMDSDLLKLNQ 2108 zebrafish
XP_008113606 1745 ---------------------------QGtnRILSERRSEQRRLLSAIGSFA---ILDSDLLKLNQ 1780 green anole
AAH27450      290 ----------------------------GtnRVLSERRSEQRRLLSAIGTSA---IMDSDLLKLNQ 324  human
XP_005921880 2019 S---------------------------GanRVLSERRSEQRRLLTVIGTTA---VMDSDLLKLNQ 2054 Burton's mouthbrooder
XP_007663751 1141 -------------------GMSIPAQPHAstRAGSERRSEQRRLLSSFTG-----SCDSDLLKFNQ 1182 platypus
XP_007255045 1665 -------------------GKSIPAQPHAstRAGSERRSEQRRLLSSF-------SCDSDLLKFNQ 1704 Mexican tetra
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap