6EMQ


Conserved Protein Domain Family
LEDGF
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pfam11467: LEDGF (this model, PSSM-Id:371545 is obsolete and has been replaced by 463284)
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Lens epithelium-derived growth factor (LEDGF)
LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.
Links
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Statistics
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PSSM-Id: 371545
Aligned: 38 rows
Threshold Bit Score: 96.5374
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6EMQ_A        11 DSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFL 90  human
XP_015221290 476 EEKLQKLHTDIKFALKVDNPDVQRCLQALEELGSVQVTSQILQKNTDVVATLKKIRRYKASSEVMEKATQVYNKLKLQFL 555 spotted gar
ELK19411      34 EEKLQKLHSEIKFALKVDNPDVKRCLNALEELGTLQVTSHILQKNTDVVATLKKIRRYKANKEVMEKAAEVYTRLKSRVL 113 black flying fox
CAG07956     471 EEKVQKLHTDIKFALKVDNPDIERCLQALEELEAVPVTSQILQRNAEVIATLKKIRRYKASaAVMEKASDVYNKLKLRF- 549 spotted green p...
OCA49057     501 EEKLQKLHSEIKFALKVDNPDIQKCLDALEELGGLQVTSQILQKNTDVVATLKKIRRYKANQSVMDKAAEVYSRIKARIL 580 tropical clawed...
XP_005993830 577 gERLQKLHSDIKHALKVDNPDIKKCLECLEELGGLQVTSHVLQKNTDLVATLKKIRRYKASKEVMDKATQVYNHLKLQFL 656 coelacanth
NP_001002037 479 EEKLQKLHTDIKFALKVDNPDIEKCLQALDELSSVQVTTHILQKNADVIATLKKIRRYKASNAVMEKATAVYNKLKLQF- 557 zebrafish
XP_018545225 104 DSTLHRIHGDIRISLKTDNPDIRKCLTALDQLSMVYVTSQHVQRHSELVATLRKMRYYRANQAIMDKASMLYNRFKNAFL 183 barramundi perch
XP_028444238 478 EEMLQKLHTDIKFALKVDNPDIDRCLQALDELAAVPVTSQILHKNAEVIATLKKIRRYKASNAVMEKASEVYNKLKLRFV 557 yellow perch
XP_017557778 477 EEKLQKLHTDIKFALKVDNPDIEKCLQALEELGSVQVTSQILQKNTDVITTLKKIRRYKASSAVMEKATEIYNKLKLQFV 556 red-bellied pir...

6EMQ_A        91 VGEGDsVITQVLNK 104 human
XP_015221290 556 -GKAEgVLKQKLET 568 spotted gar
ELK19411     114 GPKIEaIQKAARTG 127 black flying fox
CAG07956     550 VGKLDmAAKPKSEG 563 spotted green pufferfish
OCA49057     581 GPKLEsQQKTVQKV 594 tropical clawed frog
XP_005993830 657 GAKADlALKSSKPG 670 coelacanth
NP_001002037 558 IGKIE-TGKPKPNE 570 zebrafish
XP_018545225 184 VGEGEeVVSAAFLR 197 barramundi perch
XP_028444238 558 -GKPDvAAKPQTED 570 yellow perch
XP_017557778 557 -GKVE-ANKPKPEE 568 red-bellied piranha
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