Conserved Protein Domain Family
MAGUK_N_PEST
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pfam10608: MAGUK_N_PEST (this model, PSSM-Id:371162 is obsolete and has been replaced by 431391)
Polyubiquitination (PEST) N-terminal domain of MAGUK
The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerization of the whole protein.
Links
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Statistics
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PSSM-Id: 371162
Aligned: 26 rows
Threshold Bit Score: 92.8014
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5PYH5         34 KKYRHQ---DEDtGSPQEPSSPQFTDDTPG----PELVQVAEKSLSQIENV------HGFVAHSHISPMKveslecifdg 100 zebrafish
XP_005997201   95 eKHKCQ---DED-SLISDIRLPKYAESAQSfsqdPELVTVTSRSTELKESI------YSVVSHSHIALPK---------- 154 coelacanth
1_pfamImport    1 QKYRYQ---DEE-TPPLEHSPAHLAQGKSA-----EMLHMSDKNLAAMEAI------HGYTPHTHISPVKkfttitkpss 65 
8_pfamImport    1 QKYRYQ---DEE-TPPLEHSPAHLAPGKSA-----EMLHMSDKNLAAMEAI------HGYTPHTHISPVKthtqaptlap 65 
9_pfamImport    1 QKYRYQ---DEE-TPPLEHSPAHLAPGKSA-----EMLHMSDKNLAAMEAI------HGYTPHTHISPVKnagllpppss 65 
Q62936         52 GGYSSQtlpSQAgATPTPRTKAKLIPTGRDvgpvPP-KPVPGKNTPKLNGSgpswwpECTCTNRDwy------------- 117 Norway rat
XP_002934927   43 GGYSSQtlpSQPaVTPTARGKSKLVPATREnl-tPTLKAPPKSATPKMNGNsqnwwpECTCTNRDwy------------- 108 tropical clawe...
15_pfamImport   1 --YNSQ---TLQsSGSTLARSRGKLSTMRSes----iwKSPSKSVAKGKGAnsewwsDCSCPHGWHDSYQ---------- 61 
BAE89987       14 KKYRYQ---DED-A-PHDHSLPRLTHEVRG----PELVHVSEKNLSQIENV------HGYVLQSHISPLK---------- 68  crab-eating ma...
XP_006806842    9 pwYHYQ---EDD-SPLLDHGFPQLSSGLRA----PELVHVSQKNLSEIENV------HGYVSHSHISPLK---------- 64  Neolamprologus...

Q5PYH5        101 pspvvkeesppspstplsnpypqspvsvQANPPPVVVNTESLDSAPYVNGTEADFEYE 158 zebrafish
XP_005997201  155 -----------------------------AKPPPIIVNTDSLEHDPYVNGTDGVYKYE 183 coelacanth
1_pfamImport   66 lpltqs-------ytapvnyathlpevpQGNTPPVVVNTDTLDGSPYVNGTEGEIEYE 116
8_pfamImport   66 tptrdqv-----lpemsasellvlpssaKGNTPPVVVNTDTLDGSPYVNGTEGEIEYE 118
9_pfamImport   66 peltqtr----iwkcrsltcpllllislQGNTPPVVVNTDTLDGSPYVNGTEGEIEYE 119
Q62936        118 ---------------------------eQASPAPLLVNPEALEPSLSVNGSDGMFKYE 148 Norway rat
XP_002934927  109 ---------------------------eQAGAAPLLVNTDCLDPGSSVNGSDTLYKYE 139 tropical clawed frog
15_pfamImport  62 -----------------------------ASPAPIIVNTETLDTVPYVNGTEIEYEFE 90 
BAE89987       69 -----------------------------ASPAPIIVNTDTLDTIPYVNGTEIEYEFE 97  crab-eating macaque
XP_006806842   65 -----------------------------ANPAPMIINTDTLESLPYVNGTEIEYEFE 93  Neolamprologus brichardi
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