Conserved Protein Domain Family
Miga

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pfam10265: Miga (this model, PSSM-Id:370934 is obsolete and has been replaced by 463034)
Mitoguardin
Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologs, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD.
Statistics
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PSSM-Id: 370934
Aligned: 23 rows
Threshold Bit Score: 573.569
Created: 2-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ETE70118     143 WYNSLIQVKISP-GLKKLFAITAVSA---ITVLFLAHHFKRKRGKKTR---KISPWESDHLMFDYGKAS----------G 205 king cobra
Q5BLE2        31 GQSIFSQLKLSP-SLKKVLFATALGS---VALALTAHQLKRRGRKRKQt-lGKEAQKPVGIPEQLLRSSrpasl-krgpV 104 zebrafish
Q8BK03        31 GQSAFSQLRLTP-GLRKVLFATALGT---VALALAAHQLKRRRRKKKQvgpEMGGEQLGTVPMPILMARkvps--vkkgC 104 house mouse
EOB05910      31 GQSVFSQLRLSP-GLRKVLFATALGT---VALALAAHQLKRRRRRKKQiapDKCGFKPGGITVPILPTRrvss--vkkgY 104 mallard
CAP39560       6 MQGLPVGLKINDiVTKRTVLSVAAGIgigIVFANFVRYWKQRRESRIP-----LSAFIDEVPKEVDTNPsqpapslrrsH 80  Caenorhabditis ...
8_pfamImport   1 NITFTTPIKIS-------LIGVGVGI---TIIGLLARYLKRRRRNVPTtln--------------------------tnK 44 
EDW51314      12 G-GSLLPFRVST-TTKVVLFSLTAGV---ALMSVLSRFLRRRKPPRPPrra--------------------------rkY 60  Drosophila sech...
EDS26764       2 SVSRLLPFNLTT-SQKVIVVSVTAGM---AVLGVIASYLGRRRTPKPQqrr-------------------------lrkP 52  southern house ...
XP_017952118  31 GQSTFSQLRLSP-GLRKVLFATALGT---VALALAAHQLKRRKHKKKQitaDKGGLKLGGVPSSVLPVRrsss--akkgY 104 tropical clawed...
XP_014341668  31 GQSIFSQLRLSP-SLKKVLFATALGS---VALALTAHHLKRRRRRRKQiaeEKDAQKPRDVAGHLLPAArptp---vkkG 103 coelacanth
ETE70118     206 SEKNSSCSSSKQNLTLSLNSikEKGFQSYIhasgdlfnKYSGSLQSLA----SVH-SAISCPSCVCVN-SSSWDKADE-- 277 king cobra
Q5BLE2       105 PARQMMSPSTRSNDTLSGVS--SIAQS-----------KHSSSSHSIA----SMR-VPSSPNQSVNA--GAAWEAEPVae 164 zebrafish
Q8BK03       105 SSRRVQSPSSKSNDTLSGIS--SIEPS-----------KHSGSSHSLA----SMV-VVNSSSPTAAC--SGSWEARGMe- 163 house mouse
EOB05910     105 SSKRVQSPGSKSNDTLSGIS--SIEPS-----------KHSSSSHSLA----SMV-AVNSSSPTPAA--AGTWEAQAMg- 163 mallard
CAP39560      81 SGRGMRPSSSQGERSLRNSV-------------------RQNSQRSLS-------------------------------- 109 Caenorhabditis ...
8_pfamImport  45 TWKKQTNYVKSPNGDISSYTrrSMSPA-----------YPRSYLQSLQhgsvSLA-SDHQSSVSTIA------------- 99 
EDW51314      61 TGRRNRNSMRSPNDLISIAG--SKASARSG--------SPVGSTLAYS----DRL-SMASGSIGVGVLgVQNAGPGSSv- 124 Drosophila sech...
EDS26764      53 GGRKTRNSVRSPNDIISLAG--SKASGRSY--------SPGGSIHGLS----DRM-SLASGSLAAAGAg----------- 106 southern house ...
XP_017952118 105 SRSRVQSPSSKSNDTLSGIS--SLEPS-----------KHSSSSHSLT----SVV-AVNSSSVNVAS--AGPWESPEMd- 163 tropical clawed...
XP_014341668 104 SSKRVQSPSCRSNDTLSGIS--SIAPS-----------KHSSSSHSLA----SVSkSSAARGSXPFX--TLGRINNFPk- 163 coelacanth
ETE70118     278 DNMKLVNIPVTTPENLYLM-GMEL---FEEALQRWEQALTFRNRQV---EDEAsCGGIKLGAGDAIAEEHIEDIISAEFI 350 king cobra
Q5BLE2       165 EPAVGED---ANAENLYLM-GMEL---FEEALRKWELALNIRHRSH---SRASaSNS---QGSELVERHS-PEVRNHQFA 230 zebrafish
Q8BK03       164 ESVPTTD---GSAESLYVQ-GMEL---FEEALQKWEQALSVGQRGDg-gSTPTpGDSLQNPDTASEALSE-PESQRREFA 234 house mouse
EOB05910     164 DAGAGGD---SSAESLYVQ-GMEL---FEEALQKWEQALTIRQRDSastSTPVpWDGKKHQDTLSESIAE-EESQKREFA 235 mallard
CAP39560     110 ----------MNPIEADITnGQEMctdLRKTIERVHHNLEMVKNRS---------------------------SKDMERS 152 Caenorhabditis ...
8_pfamImport 100 STITLDATTGLTPQQFGLM-GLEA---LETAIGYWEDALHSYTAPL-----------------ASGGALAITNEEESEFS 158
EDW51314     125 -------VTQLTAQQLGMM-GMEA---LDTVINFWEDALAAHYSPG-------------------GLPALLTTAEDSEFC 174 Drosophila sech...
EDS26764     107 ---PIGGTTPLTPQQLGVM-GMEA---LETVISYWEDALTGRNDID--------------------IPSRLS-ADQEEFC 158 southern house ...
XP_017952118 164 ETLEEED---SNAENLYIQ-GMEL---FEEALHKWEQALNLGQRSRs--NTPLsQVNEPLNKSYSEGLSE--DSQSRQFA 232 tropical clawed...
XP_014341668 164 ----CGG---AF-ISLGFA-GMEL---FEEALLKWEQALNIRQHRG---SDMGaKMKVIQPGASGDSVSE-QEFRNKDFA 227 coelacanth
ETE70118     351 HKLELLLQRAYRLQEEFETSLGVsDPASFANEA--GNQMDNTMKDItDEFS------LRDTISIGST------------- 409 king cobra
Q5BLE2       231 ERLETLLHRAYHLQEDFGSTI---PPDSLLADLesEGTLILPTLGSsHPIQ------DDDATTVTSD------------- 288 zebrafish
Q8BK03       235 EKLESLLHRAYHLQEEFGSTF---PSDSMLLDL--ERTLMLPLTEGsLRLR------ADDEDSLTSE------------- 290 house mouse
EOB05910     236 EKLESLLHRAYHLQEEFGSSL---PSDSMLLDL--EKTLMLPLADGsLRLR------TDDEDSSISE------------- 291 mallard
CAP39560     153 IKIEGILKGLKQVEDEITMLIPHmEDFR-------DDNTEFYSVSGgTGYAgsvrtgRSRTLSVLSD------------- 212 Caenorhabditis ...
8_pfamImport 159 HYVEKVLDMACALQEHCEQLFLH------------QTSVLFRSDSTsERFV------DVDRYTVTSIss----------- 209
EDW51314     175 REIQNLLEMAYTLQEQSELLFLD------------QRSVLFREEHSiDEVEeeageaDDDRRSHKSGsvlsrags--dpn 240 Drosophila sech...
EDS26764     159 RELQNLLDAAYNLQENGELLFLD------------ERSVLYR---------------DDENKATQAAslsnghrsssdpn 211 southern house ...
XP_017952118 233 GRLEALLHRAYNLQEEFGTSI---PPDSLLMDL--EGSLMFPLAESrRALL------TYEEGSTTSE------------- 288 tropical clawed...
XP_014341668 228 QKLEGLLHRAYHLQEEFGVAL---PPESLMLDFenEGTLALPLSGSsERLY------LDDEASVTSE------------- 285 coelacanth
ETE70118     410 ----DSFVSVAE--LTE-HKESRNYYHLDSLCHCP-----LYEEALCMAEE-------GKIYSRVLRTEMLECLGDSDFL 470 king cobra
Q5BLE2       289 ----DSFFSAAE--LFE-------TFSLEDS-FHLlkpaaLYEEALSLVKD-------GDVACRSLRTELLECYSDQDFL 347 zebrafish
Q8BK03       291 ----DSFFSATE--IFE-------SLQIGEYPLPLsrpaaAYEEALQLVKE-------GRVPCRTLRTELLGCYSDQDFL 350 house mouse
EOB05910     292 ----DSFFSAAE--LFD-------SLHFEEIPFHLskpvaAYEEALQLVKE-------GKVACRTLRTELLGCYSDQDFL 351 mallard
CAP39560     213 ----DSFQSAVEefAVDiDDIDFVSEAAN-----------LEKEELKFLDEgmraamnGEVKYRKSRMDFCNCESETDFA 277 Caenorhabditis ...
8_pfamImport 210 ---lESFVSAVD--VADlREFDEFSDLNQDFYHLP-----LYQAALRQLEE-------VGIPYRSLRTDHLKCQTDIDYL 272
EDW51314     241 fdsaESFASALDq-VADlREFDGFIET--SYEEYP-----LFQSALKHHDE-------YTVPCRTIRAELMHCSTDTEYL 305 Drosophila sech...
EDS26764     212 mdsaESFASALDqvQSDlREFEDYGEVFSDVENYP-----LYQSALELLDD-------QPIPCRTIRTDMVGCNSDAEYY 279 southern house ...
XP_017952118 289 ----DSFFSAAE--LFD-------TLQLNEVPFRPpkpaaAYEEALMLVHT-------GEVACRTLRTELLGCYNDQDFL 348 tropical clawed...
XP_014341668 286 ----DSFFSAAE--LFE-------SLQFSGDSFQPakpaaLYEEALGLVRD-------RKVDCRTLRTEVLGCYNDQDFL 345 coelacanth
ETE70118     471 AKLHCIRQAFQVILSDSANRIFLAESGRRILCALILRARKNPKKFEEVFDEMISFLEQADQWIHTEMELAAYGVKHLNFY 550 king cobra
Q5BLE2       348 AKLHCVRQAFQVLLLDETHRMFFMETGKQMISGLLVKANKSPKAFLESYEDMLQYTQREETWPVSKMELEGRGVVCMNFF 427 zebrafish
Q8BK03       351 AKLHCVRQAFEGLLEERSNQIFFGEVGRQMVTGLMTKAEKSPKGFLESYEEMLSYALRPETWATTRLELEGRGVACMSFF 430 house mouse
EOB05910     352 AKLHCVRQAFQELLEDESNQLFFGEVGKQMVIGLMTKAEKNPKAFLESYEEMLHYALKPETWPTTQQELEGRGVVCMSFF 431 mallard
CAP39560     278 AKLYCVRHALTNALKDEHKRVWLAKCGRTLLADFIRHTKQDPVKFFNAYDEMLEYVSNDRNQEQLRQDVEGRGVCETGFY 357 Caenorhabditis ...
8_pfamImport 273 AKLYCIRLAFQFTFEDEKIKVWFIECGRQLISSLLFNADKDPKDFLNAYDEMLTFIKSDHHYTKTEEELKGRGVRCMTFY 352
EDW51314     306 AKLHCVRLAFQFLFKDPAVGQWICDAGRQILTDLLCLGDKDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFY 385 Drosophila sech...
EDS26764     280 AKLHCIRLAFQLLFKDPKISRWVADTGRQVLTDLLCLGDKDPKDFLVSYESMLEFLQNQDNWPDIEAELESRQVKAITFY 359 southern house ...
XP_017952118 349 AKLHCVRQAFEVLLLDERNRLFFGEVGKQMVSGLMQKAEKNPKGFLENYEEMLRYALKEDTWTTTQKELKGRGVVCMNFF 428 tropical clawed...
XP_014341668 346 AKLHCVRQAFQVLLEDESQRLFFSEIGKEMITGLMTKAGKSPKGFLESYQEMLRYTVKEETWPTTQRELEGRGVVCMNFF 425 coelacanth
ETE70118     551 DVVLDFILMDSFEDLENPPMSIQNIVNNHWLNSSFKETAVASSCWSVLKQKKQQIKVPDGFFAHFYAVCEHISPVLAWGF 630 king cobra
Q5BLE2       428 DIVLDFILMDAFEDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFIAHFYVISEHVSPVLAFGF 507 zebrafish
Q8BK03       431 DIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGF 510 house mouse
EOB05910     432 DIVLDFILMDAFEDLENPPSSVLAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGF 511 mallard
CAP39560     358 DVAVDFIILDAFEDLKSPPSAVYSVTKNYFMSMSMKYSTLNTIIWSIIKSKRQRLKNPDGFIAKFYNISETVMPAITLGF 437 Caenorhabditis ...
8_pfamImport 353 DIVLDFIFLDAFEDLENPPSSVLAVVQNRWLSNGFKETALATACWSVLKAKRRFLKFQNGFIAHFYDISEHTTPVLAWGF 432
EDW51314     386 DICLDFIILDSFKDLDAPPASVTAVVQNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGF 465 Drosophila sech...
EDS26764     360 DIVLDFIILDAFRDLDTPPNSVLAVINNRFLSNSFKETALTTAVWSVLKAKKRLLKFPNGFMSHFYCVTEQLSPLMVWGF 439 southern house ...
XP_017952118 429 DIALDFILMDAFEDLESPPSSVIAVLRNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGF 508 tropical clawed...
XP_014341668 426 DIILDFILMDAFDDLESPPSSVVAVLRNRWLSDSFKETALATACWSVLKAKRRLLLVPDGFISHFYSISEHVSPVLAFGF 505 coelacanth
ETE70118     631 LGPRNSLNELCSYFKNQILYFLKDIFDFEKVRYSSVDNLAEDLLQLLIRHTNLLLVYF 688 king cobra
Q5BLE2       508 LGPHQHLSEVCTIFKQQIVQYLKDMFDHDKVRFTSVPSLAEDILRLSHRRADILMGYL 565 zebrafish
Q8BK03       511 LGPKPQLSEVCAFFKHQIVQYLRDMFDLDNVRYTSVPALAEDILQLSRRRSEILLGYL 568 house mouse
EOB05910     512 LGPKQQLSEVCGFFKHQIVQYLKDMFDFDNVRYTTVQLLAEDILQLSRRRSEILLGYL 569 mallard
CAP39560     438 LGTDERLGELCQYFKEQVVQFVLDVFNTQRVCYRSLEEMTEDVWIVMRNRLEAVQTRM 495 Caenorhabditis briggsae
8_pfamImport 433 LGPEEGLKDLCNFFKDQVLGFLQDIFNSEKSRYSSVEDLSKSIMSHAYERYE-ITSKR 489
EDW51314     466 FGPNENLRDICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTRVNNIGVKF 523 Drosophila sechellia
EDS26764     440 FGPDEDLKEVCKYFKDQMVGFMIDMYNFQKMRYTTVEELAEDIHTNMRMRVNNIGVKF 497 southern house mosquito
XP_017952118 509 LGPKEHLAEICNFFKHQIVQYLTDMFDLDKVSYTTIQSLADDILHLSRRRSDILLGYL 566 tropical clawed frog
XP_014341668 506 LGPKPQLCEICTFFKQQIVQYLKDVYDLDQVRYTTVQSLADDILQLSQRRSEILLGYL 563 coelacanth
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