Conserved Protein Domain Family
Mitofilin

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pfam09731: Mitofilin (this model, PSSM-Id:370640 is obsolete and has been replaced by 430783)
Mitochondrial inner membrane protein
Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.
Statistics
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PSSM-Id: 370640
Aligned: 18 rows
Threshold Bit Score: 347.084
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6PFS4        39 GSSAGKivaasLLTVGGGLGGTILYAKWDPKFRSSIEKS-VPYSDQLFDMVLGAPPSPPVpi----------qkKPETVK 107 zebrafish
Q9ASV5        69 KGNSSK-----VVIGGVAIAGAFLVAYQTGYLDQYLGKEqQKLSERIHSDALTEKLEEAHhlnvpsgvedstekDGKVET 143 thale cress
P91928        68 EAGFGKvv--lFVSPLAAVGGVITYAKYDDDFRKLVEKN-VPGAGSVIKVALQEEPPFKGitknvndqidkvksGIETVT 144 fruit fly
Q16U68        37 EAGFGKvl--vvLSPFLVGGGVVAYAKYDNEFRKTLVTN-VPALEPVLKALLQEENPLDEvs-----------kKLDEIS 102 yellow fever mo...
DAA24582      40 rlSASKiagagILFVGGGIGGTILYAKWDSHFRKNVEKT-IPYSDKLFEMVLGSPPYTVPlp-----------kKPIQSG 107 cattle
NP_001006462  41 gVSVGKiigasVLFVGGGVGGTVLYASYDPRFRENVEKA-IPYSDKLFEMALGPAPYSVPip-----------kKPVQQG 108 chicken
Q9XXN2        20 SSGGLKfvgatVGAVTAGAAGVAGYASYDNEFRKKLEGV-IPGSRTILNYTIGEEEPPAP--------------RLKDLR 84  Caenorhabditis ...
Q22505        37 KSGGGKgl-alVGATVVGAGGVVGYAYVDPEFRHKVEST-VPPVKQVFDAVLGES-SLQK--------------TKQQIG 99  Caenorhabditis ...
Q5K8K8        77 PRRFRRvfvytALGVAGFYALSGYVGTKSDAYRDLFTQY-VPGGEAVADYADDNDWD--------------------NVS 135 Cryptococcus ne...
KIS72220      40 RSGLGRlfvysTVGATVFYGISTVAALNNDRYNHFFVES-IPGGERIIDYLDTHDVGQEIksinlhgygdkaidVTKTAY 118 Ustilago maydis...
Q6PFS4       108 PLQISSLSEATKDSKQPKAKAKKSDpapppsveeapapapalqsleeasaeaAHI-ISAISEVPSVPAPGTSDESPSGhs 186 zebrafish
Q9ASV5       144 QPQVTHSEASEGVQSDIELQPESDLs-------------------------sDRF-TYISSNQEETPQETVIDRAEIN-- 195 thale cress
P91928       145 STVDSVTSKVTGLFGGGSGDDKSKKskvepv---------------katpaeEKR-PSKPSEVSKTEAKPVSKPAAAAap 208 fruit fly
Q16U68       103 STISGYTSTVTGFFTGVSKEEEKKPektkp-----------------skpvaK---PAAPAAPSPAPASKAAPAKATApa 162 yellow fever mo...
DAA24582     108 PLKISSVSEVMKESKQPASQPQKQKgdtsasttagdt---lsvpapvvqheeLIK-TDHPETGEGKPKPATSEEASSTsv 183 cattle
NP_001006462 109 PLKISSVAEVMKESKQPVPKPQ----------------------------------TSKTEAVAPSEEKEDKEHEGSHai 154 chicken
Q9XXN2        85 PLQYSADPKVPPKPFEPKPVKKELIg--------------------------VKEnLKETTEPKKIEKKPENPYIGAK-- 136 Caenorhabditis ...
Q22505       100 DLKDAVVNAVPKKKEVLPPLELAPLppv----------------------lpR---EPTHVDPVDVRKDVTPMIPKPS-- 152 Caenorhabditis ...
Q5K8K8       136 GKAVRAWQSITGARPETRTEKVERKi------------------------------GEVRQEAAKVPAQVKDKADEAKdh 185 Cryptococcus ne...
KIS72220     119 DSVSGAVSRVFSGDAGASESAGDERd---------------------------AR-LRVSEARATAKAEADKLAQRAKv- 169 Ustilago maydis...
Q6PFS4       187 aaaeecckectepepavkerpaeevtarlaqQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAAHTDKLR 266 zebrafish
Q9ASV5       196 -------------------------------LPISASEDSGAKPDMPSEIISEAESVKLEAVPKPGDSPIIVNAQSSSVH 244 thale cress
P91928       209 apaa---------------------kpkdnpLPRDVVELEKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDKAVENGE 267 fruit fly
Q16U68       163 aaatvpk---------------piapkpaeeVPKSISDLERQIDVAAATAIKEYGKAVQVLKDYTNEVKKVVDESVDKLD 227 yellow fever mo...
DAA24582     184 rerppe-----------------evaarlaqQEKQEQVKIESLAKSLEDALSQTARITQQAIVAQNAAVQAVTAHANILK 246 cattle
NP_001006462 155 kerspd-----------------evaarlaqQDKEEQEKISALAATLEGALSSTARITLQAITAQESAVQAVNAHLQILK 217 chicken
Q9XXN2       137 -------------------------------TPLNPQERNEKLTESLKNHLTQAEKATKVATSAKLETIRAIEHHVQTIR 185 Caenorhabditis ...
Q22505       153 --------------------------------PDVVFAKNQQLEEKLKIAIHSAEGKVRLATEAKLKTINAINEHASILK 200 Caenorhabditis ...
Q5K8K8       186 v----------------------------vgKHTASQKIHERAEELRKAVEQKTHEAEARLKELTGEAKHKVQEATKDAP 237 Cryptococcus ne...
KIS72220     170 ------------------------------aAEKAEHQAESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTEASKDGR 219 Ustilago maydis...
Q6PFS4       267 EAMDSETPpdekstqalnealneraravddagea--------lfkakgeleklrsvidkakqskidsaRPQILAAEEN-- 336 zebrafish
Q9ASV5       245 RESETESA------------------------------------------------------------SPKDPAALKT-- 262 thale cress
P91928       268 NSLWTTLKnrasardtavataeraar-------------------------eaqekivaceialsaaaTAQNAKKVEAvr 322 fruit fly
Q16U68       228 SSSWVLLRnrtsardtalkaaedaaeda---------------------renieklhrlldsrdikcsDELKDKAREN-- 284 yellow fever mo...
DAA24582     247 AAMDDSEIagdkksaqwrtvegalkerrkavdeaad-----allkakeelekmksvienakkeevagaKSHITAAEGK-- 319 cattle
NP_001006462 218 EAMDDSETagekksaqwrtleealkdrrravdeaad-----vllkakeelektkgvienakksqipgaKSHIIAAEEN-- 290 chicken
Q9XXN2       186 EAIEAGKDgdwdsvtvahlkakrlaekdekaek-----------larnavadlvteanlggqgettqlNPLVPISKAT-- 252 Caenorhabditis ...
Q22505       201 QTVDDAKHanwenvtsalqraeaearvdsgqev-----------dgrnyidnlrkivndgkrdsttatNPLLLNAQET-- 267 Caenorhabditis ...
Q5K8K8       238 FNFSEGVEgivraaesalhktehkaaeaadkvkpaearpsspfpdtqrprelkpetvtpqvpsyegkkLYTGPPLPLGhe 317 Cryptococcus ne...
KIS72220     220 NIIQRAVDsvqvmtdigantkaapsksaapg---------------ngpkeevketyigelpvnheapVGYAAPRRDR-- 282 Ustilago maydis...
Q6PFS4       337 --------LHSMIVDLDKVVTKVQTAQSEAKIVSQYSELVNEAKAQfqqelaNITPEIQANWKGLSGkLSADDLNSLIAH 408 zebrafish
Q9ASV5       263 --------PEDGIEREVQLPGSLLKEYNLEGSDTESTGSSSIGEQI------TKETEAFPNSTEGLKdSYMTEDGKLVLD 328 thale cress
P91928       323 ------dkIKKLVDHIGNVKDELYRHKDTASVSDKYWRNVEKARNYfideieSIFPGLSLADKKLNL--SKEDLDLFILH 394 fruit fly
Q16U68       285 --------IASYLEHLKKAKEDVYKARNLATLGEKYWKKVETARNFfideieSLFPGI--NLSEKKLdLSKDDLDLFILH 354 yellow fever mo...
DAA24582     320 --------LHNMIIDLDNVVQKVQAAQSEAKVVSQYHELVVQAREDfkreldSITPEVLPGWKGMTDkLSADDLNALIAH 391 cattle
NP_001006462 291 --------LHHMIVDLDNVVKKVQAAQSEAKIVAQYHELVATAREEfqreldSITPDVQPGWKGLTGqLSTDDLNSLIAH 362 chicken
Q9XXN2       253 --------AEKLSNELDEMISNVKHVDSERIFVHDYSDRVAESRRKfqmelkAVHPNLN---YEDGMkIKKADLHTILAH 321 Caenorhabditis ...
Q22505       268 --------ANKLSHQLDEINALVNKSRQESAVLNQYKDLIEKSRQQfalemkSILPNVDIHAKDKNL--NEDELNALIAH 337 Caenorhabditis ...
Q5K8K8       318 pppgyylpPPPSTKKEKVEEKVEEIKERLPLLVPKVKEFASEEPIIsq--laSTIDSLTSSLSTPSK-ALSSDATGILNK 394 Cryptococcus ne...
KIS72220     283 --------GLQAPDHPTARLRPDPEAPKLPLLAPSIKSLSASEPMIaq--laGTIDELTVFLKETPS--SGAKAKGVLES 350 Ustilago maydis...
Q6PFS4       409 AHRRIDQLNRELAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE------DMRLEQEKKVQEVREVMEAEMRT 482 zebrafish
Q9ASV5       329 FLAAIHAAEKQQAHLDAQVFAEELRALKEKYENeLRDLRARELMRIEEAAIldkelkRERTKAAAAIKAIQERMEDKLKA 408 thale cress
P91928       395 AYTHVLAYQKELQRLQTDGELRLKRAIDSVR---GDNDSEALRAQLEYHLEae--rrKLAVENQKKIFHIHAESDKLLRL 469 fruit fly
Q16U68       355 AFTQVVAHQKELQKLQIEGDQQLKRALEAVR---GTDQSEAVKAQLEYEIAke--krELNLRNQRKLLAIRAELERNLRS 429 yellow fever mo...
DAA24582     392 AHRRIDQLNRALAEQKATEKQHIALALEKQKLEeKRAFDSAVAKALEHHRS------EIQAEQDRKVEEVRDAMENEMRT 465 cattle
NP_001006462 363 AHRRIDQLNKELAEQRVREQQHIELALEKQKLEdKKALEAAVAKALEHHKS------EIEIEQEKKVEEVREVMESEMRT 436 chicken
Q9XXN2       322 AHLRIDQLSQKLIDSKLNEEKRIQSIIAKKKEDlLEKLRLETNAKQAAVIPefd-kkKLDAELARATAEIQKKYDEKLK- 399 Caenorhabditis ...
Q22505       338 AHLKVDQLRCQLSDQQVREELHISKALEEQRLAdERIASEKLSIEMSrv------grQNELEIERALVESRSSWEGELEN 411 Caenorhabditis ...
Q5K8K8       395 AQDDLTALNARLQEVKKAEKAKLEQSISEKKKE-----FEALLKSMEAEKAks--eeGLKQTWQHERQTMVEDWRKELEG 467 Cryptococcus ne...
KIS72220     351 AQIDLEQLSQRLETIKRQEAKRVEDSLAAQAKR-YETQISKQSQEAADKLSsr--esDWQKSFEEEHAKQTQQFKEKLEK 427 Ustilago maydis...
Q6PFS4       483 QLRRQAAAHTDHLRDVLKVQEQELreeaqeilNSKMMEQEthyrrltqeqlDTFTLDMNAAYARLKGIEEAIDS------ 556 zebrafish
Q9ASV5       409 ELEQKETEAQLALSKAEELAKAEM--------ISTIAKEK-----------AAQIEKMAEADLNIKALSMAFYA------ 463 thale cress
P91928       470 QLKKQAEAHADHIKDIVAQRETDLtrsfkrelEDKLATEK-----------ANYKLQLAGMLGKLRGMDAALAE------ 532 fruit fly
Q16U68       430 QMKRQSEAHTDHLADALAQKEVEMkrkfqrelDEKITTEQ-----------AAYKLQLAAMLGKLKGMDAALKEiddemk 498 yellow fever mo...
DAA24582     466 QLRRQAAAHTDHLRDVLRVQEQELkyefeqdlSEKLAEQElqfrrlsqeqvDNFTLDINTAYARLRGIEQAVQS------ 539 cattle
NP_001006462 437 QLRRQAAAHTDHLRDVLKIQEQELkvefeqnlSEKLSEQEmqfrrltqeqlDNFTLDINTAYARLKGIEQAVES------ 510 chicken
Q9XXN2       400 --------------EVVRTQKQLYdiehakdvDEAVLKER-----------NLHSSAVGKALAQLAGIEKALSG------ 448 Caenorhabditis ...
Q22505       412 QLKRTASAHSEHLEQVIRTQRQLFeieqnqkvEEAVLQER-----------NLHSKQVGAALSRLEGIEEALGS------ 474 Caenorhabditis ...
Q5K8K8       468 ELEQQRQSIEQRLREEVVSQGIELqrrwlrsiKTQVETER-----------GGRLAKLDSLTTSLKQLERITLD------ 530 Cryptococcus ne...
KIS72220     428 ELATQSQIINERLKEEVIAQGIELqrrwmkdiKAKVEEER-----------GGRLSKLDELATDLKSLEKVSLD------ 490 Ustilago maydis...
Q6PFS4       557 -HVIAEEEARKAHQLWLSVEALNYTLKSAgad-----sptEPLEGAVRAIKES-----CAENEFAQALAIAIPEESLNR- 624 zebrafish
Q9ASV5       464 -RSEEARQSHSVHKLALGALALDDTLSKG-----------LPVQKEIDTLQTYle--gTHKDSILGLVLSSLPEEARSN- 528 thale cress
P91928       533 -RADAERTANQAQALWAACQALWASVRAAtpgvh-ykdrlRPLKNEINAIAKV-----AKGDDLVAAVLESVPKEAQER- 604 fruit fly
Q16U68       499 gRADAEKSAHQAQALWGACQSLWSSIRSGqpgks-wreqlRPLKDEIGAVARA-----AEGDELVGVVLKGLPETAKNR- 571 yellow fever mo...
DAA24582     540 -HAVAEEEARKVHQLWLSVEALRYRMKTAsad-----lptVPLGSAVEAIRAS-----CSDSEFAQALTAALPPESLTR- 607 cattle
NP_001006462 511 -HAVAEEEARKAHQLWLSVEALKYCMKTAsgd-----sptEPLESAVKAIKAS-----CSDNAFTEALTAALPQESLTR- 578 chicken
Q9XXN2       449 -HLQMDIENRKSKQMWLATQNLKGTVIFGnrasccmegrrAPLGDQMKTLLSCcg--gGNSDEFVKTINTAMSKTSKVR- 524 Caenorhabditis ...
Q22505       475 -RVALDNENRRAKQFWIACHNLIDTLKHGnkagnniderrLPLNESLNLLKEV-----NPEDEFVNAIIDSFPKQATTV- 547 Caenorhabditis ...
Q5K8K8       531 -NSATLDDNVRLHKIWSALRAVQSKVDSGd----------LAFDDELRALKSLstptaSSGEGVVRSALEQIEKSGIPQt 599 Cryptococcus ne...
KIS72220     491 -NSSVLDENLSVHTLWTAVRAVQHALDDAsa-------tkRPFAEQLRVLKGTs---kARDDPVLSAAIEALDASGAADt 559 Ustilago maydis...
Q6PFS4       625 GIYSEASLRARF-YDIRRLARRVALI-DETRNSLYQYFLSYLQSVLLFERDQeapp-----aklaPEDLDTFKLLAYATY 697 zebrafish
Q9ASV5       529 GTDTVLQLNQKF-DTLKGTLRHFSLI-PPGGGGILAHSLAHVASSLKFKEVD-------------QANGGIESVIKKVDN 593 thale cress
P91928       605 GVYPEDALRERF-LNVERVARRLALV-PEEGAGLPIYFLSYLQSLFILRPDNpiskdelenkpfdYSKLDTYDILNRARY 682 fruit fly
Q16U68       572 GVYPEDALRERF-IKVEQVSRRLALV-PAEGARLPLYFLSFLQAALIAKPDVpiskdeledkpfdFNKLDTYDILNRARY 649 yellow fever mo...
DAA24582     608 GVYSEETLRVRF-YAVQKLARRVAMI-DETRNSLYQYFLSYLQSLLLFPPQQlkpp-----aelcPEDADTFTLLSYASY 680 cattle
NP_001006462 579 GVYSEEALRARF-YTVQKLAKRVAMI-DETRNSLYQYFLSYLQSLLVFHPQQlkpp-----aelsPDDLDTFKLLSYASY 651 chicken
Q9XXN2       525 GEYTEQDLNTRF-NKVCRIGRRVAYV---NEGGALAHLYSWLKSSLTIELVPkkgan----esltPAVENNFTLLTRAEQ 596 Caenorhabditis ...
Q22505       548 GTYTEQDLKNRF-EQLYKIGRKTASI-DENGGTLGAYFWSYVKSLFLVDMPQqygnl----daidVNNTDNYEILSRAKQ 621 Caenorhabditis ...
Q5K8K8       600 GVKSFAALSSWFtNTVAPRIQSSSLVpAPEEATVISHLASAGLSKIMFRPQAgr-----------vPGDSVGAVLARAEW 668 Cryptococcus ne...
KIS72220     560 GVETFTTLKQWFdDKVGPRVRQVSLVpSPETSGVLSHLASAALSPILFH-KKgl-----------vPGQDVPSVLARAEY 627 Ustilago maydis...
Q6PFS4       698 SIERGDLELAAKFVNQ-LRG-ESQRVAQDWLKEARLTLETKQVISLLSAYAN 747 zebrafish
Q9ASV5       594 YLAEGKLAEAAATLEEgVKGsKAEEIVSDWVRRARNRAITEQALTLLQSYAT 645 thale cress
P91928       683 HVDRSDFLQALKYMNL-LQG-ASRKIAGEWMKEARLMLETQQAANTLMAHAA 732 fruit fly
Q16U68       650 WLDRGDLVKTVQYMNL-LQG-ASRKAAMDWLNEARLLLETQQAASTLMAHAS 699 yellow fever mosquito
DAA24582     681 CLEHGDLELAAKFVNQ-LKG-ESRRAAQGWLKEARVTLETRQIVEILTAYAS 730 cattle
NP_001006462 652 CIEHGDLELAAKFVNQ-LRG-ESRRVAHDWLTEARMTLETKQIVDILTAYAS 701 chicken
Q9XXN2       597 LWKSGKKSDAIRVLQL-TDG-ATRRVAADFIADARRQHEALLLSRLLLAHAA 646 Caenorhabditis elegans
Q22505       622 YVHNGDLDKAIRVVQL-LKG-QPAHLARDWIVDTRSYLESRLLAQLLVAHAA 671 Caenorhabditis elegans
Q5K8K8       669 CLAEKDLDGAAREINS-LTG-WPAKLANDWLQQARRKLEVQQALEVVATEAT 718 Cryptococcus neoformans
KIS72220     628 YLDRKDLDSATRELNQ-LKG-WPKLLASDWLAASRKRLEVQQALDVVQTEAS 677 Ustilago maydis 521
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