Conserved Protein Domain Family
Biliv-reduc_cat
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pfam09166: Biliv-reduc_cat (this model, PSSM-Id:370334 is obsolete and has been replaced by 462699)
Biliverdin reductase, catalytic
Members of this family adopt a structure consisting of four alpha helices and six beta sheets, in an alpha-beta-alpha-alpha-alpha-beta-beta-beta-beta-beta arrangement. They contain a catalytic active site, capable of reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
Links
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Statistics
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PSSM-Id: 370334
Aligned: 13 rows
Threshold Bit Score: 194.546
Created: 13-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_418872    128 YKQLKKEVAGKDLVKGTLHFTGSVLDETKAGFPAFSGIARLTWLIDLFGDLTITSASREEQKDKNYSRMTVHFQTANKKP 207 chicken
XP_005630976 133 FAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEEQKEDQYMKMTVCLETENKRP 212 dog
XP_005809267 128 YKQLKKEVEGKTLLEGSLHFAGGAL-KPGFGFLAFSGIARLSWLADLFGELSVSAATFEEDAEQGYSKMTAQLLTSDSKP 206 southern platyfish
XP_006634403 128 YKQLKKDVTGKNLVEGTLHFTGGPL-QPGFGFIAFSGIARLTWLVDLFGELTVTSANVEEDKEKKYIKMTAHFQTKDKSP 206 spotted gar
NP_001006896 128 YKQLKKEVQGKKLVEGVLHFTGGHLDENLSGFPSFSGIARLSWLVDLFGDLIVTSATREEQKELNYSKLTAHFLTAENRP 207 tropical clawed...
XP_003763167 126 FAFLKNEVAGKKLLKGTLHFTGGPLEKERFGFLAFSSIARLSWLVSLFGELAVISATMEEQEEKKYLKMTVNLETVNKRP 205 Tasmanian devil
NP_001070069 128 FKQLKKDISGKTLEEGKLHFTGGPL-KANFGFPSFSGIARLTWLVVLFGELTVTSVDLVEEKENKYMKMTAHLLTQQHKP 206 zebrafish
XP_007250759 128 FKQLKKDIAGKQLEEGSLHFTGGPL-KPGFGFPAFSGISRLTWLVDLFGELSVKAATLEEDEDRKYSKMTAHFLTKDQKP 206 Mexican tetra
XP_003456769 128 YKQLKREVEGKTLQEGTLHFTGGAL-KPGFGFPSFSGIARLTWLVELFGELSVSAATLEEDPANSYSKMTAKLLTSDNRS 206 Nile tilapia
CAF90802     128 FKALKRELEGKTLQEGTLHFTGGPL-KPTFGFPAFSGVARLTWLVELFGRLSVTAATLEEDPEKNYSKMTATLKTSSDRS 206 spotted green p...
XP_020836937 136 FAFLKNEVRGKELLEGTLHFTGGPLDRERFGFLAFNSIARLSWLVSLFGELAFISASMEEQQENQYQKMTVNLETMDKRP 215 koala
XP_003429977 140 eypmalshvaaqelwklaeqkAGPLDEERFGFPSFSGISRLSWLVDLFGELSLVSATMEEQKDKKYLKMTADLKTADQRP 219 platypus
XP_003222261 129 YKQLKKEVEGKELVKGTLHFTGGPLDEERSGFPAFSGIARLSWLVDLFGDLTVTSATREEQKEKNYSRMTAHFLTADKRP 208 green anole

XP_418872    208 LTWIEERGPGMRREKKINFCFTSGCLENFPQ 238 chicken
XP_005630976 213 LTWIEEKGPGLKRNRHLSFHFKSGSLENMPN 243 dog
XP_005809267 207 LTWIEERQAGLPRTKKINFVFDGFTLTQIPP 237 southern platyfish
XP_006634403 207 LTWIEERAPGLGRVKNISFRFDTGVMDCLPV 237 spotted gar
NP_001006896 208 LTWVEERAPGMKRDKHIHFSFTTGILDTLPS 238 tropical clawed frog
XP_003763167 206 LTWIEERGPGLKRERHINFLFESGLLESIPP 236 Tasmanian devil
NP_001070069 207 LTWIEERGPGLGRAKHVEFRFQDVTITELPA 237 zebrafish
XP_007250759 207 LSWIEERGPGMGRTKRINLRFDSCTLTELPA 237 Mexican tetra
XP_003456769 207 LTWIEERQPGLPRAKNINFQFDSGTLTQIPP 237 Nile tilapia
CAF90802     207 LTWIEERGPGFPRAKNIHFRLDGCTLTQIPA 237 spotted green pufferfish
XP_020836937 216 LTWIEERGPGLKRERRINFLFESGRLESIPP 246 koala
XP_003429977 220 LTWIEEKGPDLKREKHIKFSFTSGCLENLPA 250 platypus
XP_003222261 209 LTWIEERAPGMKRDKIINFCFKSGCLERLPD 239 green anole
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