Conserved Protein Domain Family
Creb_binding
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pfam09030: Creb_binding (this model, PSSM-Id:370251 is obsolete and has been replaced by 462659)
Creb binding
The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery.
Links
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Statistics
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PSSM-Id: 370251
Aligned: 35 rows
Threshold Bit Score: 39.2161
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ETE71031      1748 Qq---qPGMP---------------------RPVLAm------------------------------------PGQ---- 1763 king cobra
Q09472        2007 Q-----SGMP---------------------RPAMMs------------------------------------VAQh--- 2021 human
10_pfamImport   16 Qqs----qGQ---------------------AALMSi-----------------------------------sQQQgavg 35  
XP_005448114  2213 Qqp---qpGN---------------------RGLMQai------------------------------------------ 2226 Nile tilapia
XP_011603281  2233 Qqp---qpGN---------------------RGMMPglgv---------------------------------------- 2248 torafugu
AWP17351      2042 qqlqqvqqaG---------------------SGQLQp-----------------------------------tNQQwgp- 2064 turbot
XP_011602062  2232 RqalmnQMGH---------------------PGMMAaqqqqqmiqqqqqhhhhqqqqqqqqqsqgqaalmsisQQQgavg 2290 torafugu
XP_011476787  2245 Rqa---mmTQmghsammptqqqpphqptpghAALMNma----------------------------------qQQQgavg 2287 Japanese medaka
XP_027898229  2115 avaaatgmmpshphhqpgqpqqmamghggpvgmvgpqgmqlqnqtavrahmdqqqgamqgmmaagghmqqqpppqgnlpp 2194 Monterrey pl...
XP_014352799   960 Q-----AGMQ---------------------RPPMMq------------------------------------MPQq--- 974  coelacanth

ETE71031      1764 -----QTVTG----PRMPG---------------------------------------------------VQP-----PA 1778 king cobra
Q09472        2022 ----gQPLNM----APQPG---------------------------------------------------LGQvg-isPL 2041 human
10_pfamImport   36 gvqagAASGA----TGVAG---------------------------------------------------MVPpggniPQ 60  
XP_005448114  2227 ---ggAGGVP----ASLAAgsg------------------------------------------------------nlPQ 2245 Nile tilapia
XP_011603281  2249 --sggAVGLP----ASIAG---------------------------------------------------AAasg-nlPQ 2270 torafugu
AWP17351      2065 -------ggPamnpQQRPGmmahmapqqqpgaaqqqqpmnqqqpqpgnrgmmqvmgvsggaagaptpitgVAgsg-nlPQ 2136 turbot
XP_011602062  2291 gvqagAASGA----TGVAG---------------------------------------------------MVPpggniPQ 2315 torafugu
XP_011476787  2288 gvtggVVPGA----AGVPG---------------------------------------------------AAgg--niPQ 2310 Japanese medaka
XP_027898229  2195 qrmgaplqnpqqpqqqwtgpgippqqrqammnqmshqammaaqqqqqqqqqqqqqqqqtshqpaqghaammnivqqqqgs 2274 Monterrey pl...
XP_014352799   975 ----aQQMNM----QPQPG---------------------------------------------------MGQvp-gaPQ 994  coelacanth

ETE71031      1779 RT--IPPNALQELLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVaNQPG 1833 king cobra
Q09472        2042 KPgtVSQQALQNLLRTLRSPSSPLQQQQVLSILHANPQLLAAFIKQRAAKYAnSNPQ 2098 human
10_pfamImport   61 -------AALQELLRTLRSPSSPHQQQQVLNILRSNPQLMAAFIKQRASKYK----- 105 
XP_005448114  2246 -------AALQDLLRALRSPSSISQQQQVLNILRSNPTLMAAFIRQRAARYQgAQgg 2295 Nile tilapia
XP_011603281  2271 -------GALQELLRTLRSPSSPLQQQQVLNILRSNPALMAAFIRQRAARYQgGQgg 2320 torafugu
AWP17351      2137 -------AALQDLLRTLRSPSSPLQQQQVLNILRSNPTLMAAFIRQRAARYqgaqgg 2186 turbot
XP_011602062  2316 -------AALQELLRTLRSPSSPHQQQQVLNILRSNPQLMAAFIKQRASKYKggpgg 2365 torafugu
XP_011476787  2311 -------GALQELLRTLRSPSSPLQQQQVLNILRSNPQLMAAFIKQRAAKYKgGQgg 2360 Japanese medaka
XP_027898229  2275 aggnipqAALQELLRTLRSPSSPLQQQQVLNILRSNPQLLAAFIKQRASKYKgGpgg 2331 Monterrey platyfish
XP_014352799   995 AN----RGALQDLLQTLRSPSSPMQQQQVLNILRSNPQLMAAFIKQRAAKYQggksp 1047 coelacanth
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