2KRG


Conserved Protein Domain Family
EBP50_C
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pfam09007: EBP50_C (this model, PSSM-Id:370238 is obsolete and has been replaced by 462654)
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EBP50, C-terminal
This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control. It includes a disordered section between two reasonably well conserved hydrophobic regions.
Links
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Statistics
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PSSM-Id: 370238
Aligned: 35 rows
Threshold Bit Score: 96.3317
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2KRG_A         93 TDEFFKKCRVIPSQEHLNG------------PLPVPft--ngEIQKENSREALAEAAles--prpALVRSAS-SDTSE-- 153 human
19_pfamImport   1 TDAHFKKRGVVPTVALVTVrlr-----------------wsiNIERLHRRSLERQLLhtlhpqqpRKQHTGG-SRRSSle 62 
11_pfamImport   1 TDQLFHRLGMRPTSSQVKGq----------------------vYQPVMKITVTNSPTtstspkslSDGSSASvSSRSS-- 56 
18_pfamImport   1 TEEYFKRCNIEPSEEHLTG------------PLPVP--------ERSEEVHTHTHTLsl---------fcSAvSSASS-- 49 
16_pfamImport   1 TEEYFKRCNIEPSEEHLTG------------PLPVP--------ERSEEVHTHTHTLslfwkrmaKVSLSSAvSSASS-- 58 
1_pfamImport    1 TEEYFKRCNIEPSEEHLTGt----------rPLPVP--------ERSEEQRLHKKITaer---maKVSLSSAvSSASS-- 57 
14_pfamImport   1 TEEYFKRCNIEPSEEHLTG------------PLPVP--------ERSEEVHTHTHTLsl--------------------- 39 
15_pfamImport   1 TEEYFKRCNIEPSEEHLTG------------PLPVP--------ERSEEVHTHTHTLsl--------------------- 39 
17_pfamImport   1 TEEYFKRCNIEPSEEHLTG------------PLPVP--------ERSEEVHTHTHTLsl--------------------- 39 
CAG06048       90 TDELFLTLGLPPTTSHDKevyvdasaassepPTPSPtvelpaADPPSINITVTDSTVetalqrsrPNGSSASqSSRSS-- 167 spotted green ...

2KRG_A        154 -------ELNSQDSPPK---QDSTAP------------------------SSTSSSDPILDFNISLAMAKERAHQKRSSK 199 human
19_pfamImport  63 eplgfkfEKTYEEGSRMmdpFAE------------------------------------MGLSATAAEEKMKIHAKE-KK 105
11_pfamImport  57 -------ITQSELSSSDmsfQVHDEDdg---------------------rVLDPFMDSGLRFSPTAAEAKLKALAGRNKK 108
18_pfamImport  50 -------ETAATTSTPPe------CSptsdiq-------------kkievQKSDGEAEGLGIGMSVAQAKERAQQKRAVK 103
16_pfamImport  59 -------ETAATTSTPPekiki-----------------------tseevQKSDGEAEGLGIGMSVAQAKERAQQKRAVK 108
1_pfamImport   58 -------ETAATTSTPPevqILQTCSlysknsvpq------lviykkrevQKSDGEAEGLGIGMSVAQAKERAQQKRAVK 124
14_pfamImport  40 -----fwTTAATTSTPPevqILQTCSlysknskkk------knrsarnevQKSDGEAEGLGIGMSVAQAKERAQQKRAVK 108
15_pfamImport  40 -----------fwNSSHhlhSARDCSptsdiqkksnlqcnlkikitseevQKSDGEAEGLGIGMSVAQAKERAQQKRAVK 108
17_pfamImport  40 -----------fwNSSHhlhSARDCSptsdiqkksnlq-nippqhslenvQKSDGEAEGLGIGMSVAQAKERAQQKRAVK 107
CAG06048      168 -------TTQSEISSSDmsiPvpdeddrr---------------------isdpfieSGLRLSPTAAEARQKFLASRAKK 219 spotted green ...

2KRG_A        200 RAPQMDWSKKNELFSNL 216 human
19_pfamImport 106 KAPQMDWIKKYELFSNF 122
11_pfamImport 109 RAPAMDWNKKHETFSNF 125
18_pfamImport 104 KAPPMDWRKRNELFSSL 120
16_pfamImport 109 KAPPMDWRKRNELFSSL 125
1_pfamImport  125 KAPPMDWRKRNELFSSL 141
14_pfamImport 109 KAPPMDWRKRNELFSSL 125
15_pfamImport 109 KAPPMDWRKRNELFSSL 125
17_pfamImport 108 KAPPMDWRKRNELFSSL 124
CAG06048      220 RAPPMDWSKRQEVFSNF 236 spotted green pufferfish
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