pfam08773: CathepsinC_exc (this model, PSSM-Id:370111 is obsolete and has been replaced by 462598)
Cathepsin C exclusion domain
Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini. It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor.
Jiyao W et al.(2023). "The conserved domain database in 2023.",