5N9J,5OQM


Conserved Protein Domain Family
Med14
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pfam08638: Med14 (this model, PSSM-Id:370023 is obsolete and has been replaced by 462543)
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Mediator complex subunit MED14
Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.
Links
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Statistics
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PSSM-Id: 370023
Aligned: 142 rows
Threshold Bit Score: 101.023
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5N9J_A             24 FYPLPEIVETFSHHVLQELVSLAEVLP---SMSNVEKKKKILDWLLRSRAFTMRLLVLARW--VHL--SPSVHRCI-DVV 95   fission y...
EGD73067            3 AVPLRLLVDMIVQRAYKDLADMTETVA-----PARQRQQELMRYLHEARQRFMRLLVILRW--LSK--SGQADNVA-TLV 72   Salpingoe...
jgi:OSTLU_93026   251 atTLADVVERVARACHVELRQLVERCA---GADARARAAELARYAHRARQRLVRCAIVERW--SRK--SAKIATVAtNAH 323  Ostreococ...
jgi:MICPUN_98903   12 tvgqSELVERLVHVAYTDLQRLCNNLP---GQPELDRKRELARYLHNLRQRLTRLHVLVEW--APKnrAAQIAVKCgDMM 86   Micromona...
EEH57781           10 TVSLTELVDRVVHASYGELTSLANALP---GQPEPDRRRELARFLHVTKQRLARLGAIAEW--APVqrRAQISVTCgDML 84   Micromona...
EAY17939           16 pYPLHDVVAHFVSRSFSALTNTLEV-----NSEDTVHNLELMRVLNTIFVNATKVLMLFRW--NNI--YPQSSDIC-NYL 85   Trichomon...
EDO08036            6 tVSFIDLLARCVQRCVVDWKLFCYRQSndgSYVYNHARTGIIQFTRAQREIFLKLYVLYQF--SLH--MPKLEKVI---- 77   Babesia b...
CBJ25901           20 tllaSELCLRQTDRAFHDIRRLANILS---RVNHDSRREDLLDYIRSNRARFLKAYAIISWlsGNH--GELVANAS-NAL 93   Ectocarpu...
CBK21375           15 ikncgDLVRNSLVRIYTELVNAVDSAPa--ESRDNQSYLKMVSTSERCRFLVVELYALLKW--TKN--IDTLGCCQ-EMA 87   Blastocys...
XP_002257570       56 giSYGMILKKVARRSINDWSLFCDRVDndnGDNCDYLRSALIQYCRHMRECFLKLLEINKL--KKN--YKEINDII-KII 130  Plasmodiu...

5N9J_A             96 AFL-QGQKFCFQNLVHVL-QDIRYQLSFAR-----LRNSDLVTALDILSTGTSLRLanaPTSKly--------mlSESPL 160  fission y...
EGD73067           73 QAT-HMKHLTVLETANAL-HGHVESMAMAT-----LPSYDVPHAVDVLGSGEYPRM---PRNIel--------llPEPPL 134  Salpingoe...
jgi:OSTLU_93026   324 LTL-RAHEEAFAKLADGL-FHLHQQIEWAK-----APAWDLAGALNVLCDGDYELGreiSEIGvgrv----aateETEET 392  Ostreococ...
jgi:MICPUN_98903   87 GQL-RQHDMAFADAADRL-YGLRQQMDWAA-----GPLYDTPGALDVLCNGKYSNL---PRAIad---------vAPKPV 147  Micromona...
EEH57781           85 GQL-AQHDAAFTDGADRL-FALHSQLAWAK-----APLYDLPGALDVLCRGRYTDM---PHAAfee------vknAPKAA 148  Micromona...
EAY17939           86 MAT-RAQAKFIQDYLTNMlRLYNSEMDRLK-----TPMYDVMGAIDVIVGRGYSRL---PLMIy-----------PPLAI 145  Trichomon...
EDO08036           78 -----NATHAFEGYLEKCgREMSLNIRKVQstdlvTPPPNTALAVDLLSTGTYTRM---PTMLaqlahaaktntvPLPPL 149  Babesia b...
CBJ25901           94 AEA-RSQREQIDACQDQF-FFMHGGLFGAR-----QRLYDVPVAVDVLIGGRYPHL---PKGIeycg-----gdiDPRPI 158  Ectocarpu...
CBK21375           88 ISF-NQNNDVLQYIRDQL-GYLSVSLRECM-----QPIFPLNSALSVLENGSYPFI---SLVC------------DSRAC 145  Blastocys...
XP_002257570      131 LEYkENYRELKNKYQYDL-YICKVKIMDLQ-----INESNVLCAIDLLSTGKYTRF---PLLFkei------lmnPSDSF 195  Plasmodiu...

5N9J_A            161 --ST------------------KQILQTLHALNMLIRIRLSL-----------YEIIPTPFQH-FTIANGRCTFTVPNEF 208  fission y...
EGD73067          135 --LK------------------SDVDRALSWLHMQIRGRLA------------DEPAPRGLSA-VTIGKGRLTLTCGGLY 181  Salpingoe...
jgi:OSTLU_93026   393 eeTR------------------ERRLDFERRFEEEMTERLVRskthgcatrddHSEWPNEKFKvFAIGGGKVEVGVEGEY 454  Ostreococ...
jgi:MICPUN_98903  148 plETdpe-------------liRVRDERCRRFDIEIRGLLVDer--------eRGTMPKAMKV-FSVRNGECVVGVPGEY 205  Micromona...
EEH57781          149 --AAregapkteaqvaeeakqqRAKEDREKRFNAEIRGRLLEveag----vatGGTKPRAMKV-WEISRGQAIVGVPGEY 221  Micromona...
EAY17939          146 pkYE------------------KDPQGMLNLIKDKLITYLT------------SQTLPMH-SR-VTFENGVAKIHVPNQY 193  Trichomon...
EDO08036          150 --SD------------------EDADLTIERIYSEYRYMFN------------SAKCKDRGVK-MECRNGQCILSHDGMF 196  Babesia b...
CBJ25901          159 feLP------------------ANREEIVLRVDRAIRLALLR-----------RGGVPNQFTS-HTVKNGVLTLTVNGEF 208  Ectocarpu...
CBK21375          146 fqSR------------------ISMDEGKELIMRILRTRIV------------TEDIPAFVSN-ISVEDSEIVCTEESLF 194  Blastocys...
XP_002257570      196 --IP------------------NLDMNEINILKKRIVDEFLIny--------ySSKIPKDKVN-FIFSDGLIELDVVNEV 246  Plasmodiu...

5N9J_A            209 SVSLTT 214  fission yeast
EGD73067          182 SMAFTI 187  Salpingoeca rosetta
jgi:OSTLU_93026   455 RATLSL 460  Ostreococcus lucimarinus CCE9901
jgi:MICPUN_98903  206 RATLTL 211  Micromonas commoda
EEH57781          222 RAVLTL 227  Micromonas pusilla CCMP1545
EAY17939          194 NLYLSY 199  Trichomonas vaginalis G3
EDO08036          197 NIAliy 202  Babesia bovis
CBJ25901          209 ELMVTL 214  Ectocarpus siliculosus
CBK21375          195 TLYLSV 200  Blastocystis hominis
XP_002257570      247 KVSLit 252  Plasmodium knowlesi strain H
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