5NPV


Conserved Protein Domain Family
ATG16
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pfam08614: ATG16 (this model, PSSM-Id:370001 is obsolete and has been replaced by 462536)
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Autophagy protein 16 (ATG16)
Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.
Links
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Statistics
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PSSM-Id: 370001
Aligned: 112 rows
Threshold Bit Score: 100.769
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5NPV_B        25 AFEEIilqYNK-----------LLEKSDLHSVLAQKLQAEKHDVPNRHEISPGHD----------GTw------------ 71  human
GAC75551      55 QHDAMfqqYRK-----------LAEQTRMLKQRNRALLNAAAVAPSPSSASASSPagatsgaaspSPsvtpa-------- 115 Moesziomyces an...
EIM21779      22 INESYadnYKR-----------LLQQYHIIKEQNDTLIKASEEPSTdtnlsst--------------------------- 63  Wallemia mellic...
EOQ99485      19 LNNFYtdnFKI-----------LLQQFIQLKQENLTLLKASETPLDsne------------------------------- 56  Wallemia ichthy...
XP_004348800 121 SFASLid--------------hHIKQMDVLDEHQAKMtsatr------------------elaslQQenrelkhqlamsk 168 Capsaspora owcz...
EFA82370      44 AFSEIikvYND-----------LMKRERQLQERNTIYEKEilalr---------------nekrgEKgastssss----- 92  Heterostelium a...
EGG15547      39 AMAEVvknYHD-----------LLKRQRSLVDLNQIYEKEivtlr---------------nekrgDKgssnnqstnn--- 89  Cavenderia fasc...
EGC28544      49 CYSDImkiYSD-----------LLKRERTLNDRTLLYEKEivslr---------------kdanrGGgsgggsgss---- 98  Dictyostelium p...
O15736        62 NYSEFmriYTD-----------LLKRERTLNDRTLLYEKEivslr---------------nekktQQqppsgsskmdsss 115 Dictyostelium d...
EGF83360      50 PFVSLfqaYNDavmiaehrsaeILNIQSQLSLLRAELsdttq------------------qlaeaRQngqvnwi------ 105 Batrachochytriu...

5NPV_B        72 ----------nDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLNNQMQRKDREMQMNEAKIAECLQTISDLETECLD 141 human
GAC75551     116 ------atsvqLAYITSLEQQLASLRDEVATLYKTQGQNAQRLLLMNESHREKEDEARRQSELLAKLQIDHEKLRRQADD 189 Moesziomyces an...
EIM21779      64 -----ngnklqAALVHSLQQQLHSTRDELTNLYKGQNQSSQRLLEMNETLRERDDNLRAIEAENLSLKASVSRLSKARED 138 Wallemia mellic...
EOQ99485      57 --------niqSAFIQSLQSQLHSYRDELTNFYKSQNIHNLKLLNLNELLRDKDNSLRAIEAENLSLKASVSRLTKARED 128 Wallemia ichthy...
XP_004348800 169 dhsemssalavRDKVSALEEKLQRTQEELTESYKLKGQNAQMLLDLSQQIKVKDEELRQRQTEHKELLARIATSEKACED 248 Capsaspora owcz...
EFA82370      93 ----sgsvsnrGKTIEELENKIYKLQEDLTLSYKTSADNASSLLSLNDKNKDLQNEMVSKEIELERVRSMLTSSEDSYKR 168 Heterostelium a...
EGG15547      90 --ssvggsmsrGKTIEELENKIYKLQEDLTSSYKRSADNASSLLSLTDKNKDLQNELISKDIELEKVRHILNGSEDNYKK 167 Cavenderia fasc...
EGC28544      99 --sgtsstssnKGSIEEMEQKLYKLQEDLTNSYKRNAENATSILNLNDKNKDLQNEIMSKEIEVDRAKQVLQQNDDAIKR 176 Dictyostelium p...
O15736       116 sssssnrvsgmGSTIEEMEQKLFKLQEDLTNSYKRNADNASSILLLNDKNKDLQNELMSKEIEIERIRSTIQQDLDSIKR 195 Dictyostelium d...
EGF83360     106 -----nsnpdtLARLANLDQEVKQLKEEQTDLYKTNAGSAQRVLNLMDASHVDKELIKSMTERVDQLLNLNRVLTTKLSD 180 Batrachochytriu...

5NPV_B       142 LRTKLCDLERANQTLKDEYDALQITFTALEGKLR-------KTTEENQELVTRWMAEKAQEANRLN 200 human
GAC75551     190 LTHAVGEKDRGIQILQDELATLSLEVSQIEARNQ-------DLKKDNASLLQRWLDRMNQEADRMN 248 Moesziomyces antarcticus T-34
EIM21779     139 DVEGKRERERGMEALQDEITTLRLELEQIEIRNQ-------NLKNDNAALIQRWLDRMNQEADKMN 197 Wallemia mellicola CBS 633.66
EOQ99485     129 DFEGKRERERGIESLQDDLATLKLELDQVELRNQ-------DLKNDNANLLQRWLDRMNDEAQHMN 187 Wallemia ichthyophaga EXF-994
XP_004348800 249 VTARFNESMVAIQILQDELQALQLELLKVEERNK-------ILEVENTSLVERWLRKMNEEALKMN 307 Capsaspora owczarzaki ATCC 30864
EFA82370     169 LEAIIEEKTTVTQILKDELSALQSEFLHNESKVI-------KLEQENSELLERWIRKKNEEASKMN 227 Heterostelium album PN500
EGG15547     168 LEYVIEEKTTVTQILKDELSALQAEFLHNESKVI-------KLEQENGELLERWIRKKNEEASKMN 226 Cavenderia fasciculata
EGC28544     177 LEMTIIEKENVSQILRDELTSLQTEYLHNESKVV-------KLEQENSSLVERWLRKKNEEASKMN 235 Dictyostelium purpureum
O15736       196 LEMVVIEKENVSQIIRDELSSLQTEFLHNESKVV-------KLEQENSSLVERWLRKKNEEASKMN 254 Dictyostelium discoideum
EGF83360     181 NQDLIKEKDHVIQILRDELSAHQLELIQREEQLNvktkrvaELEADNKTLLERWIMLKQKEASHMN 246 Batrachochytrium dendrobatidi...
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