Conserved Protein Domain Family
CTNNB1_binding

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pfam08347: CTNNB1_binding (this model, PSSM-Id:369826 is obsolete and has been replaced by 462440)
N-terminal CTNNB1 binding
This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.
Statistics
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PSSM-Id: 369826
Aligned: 23 rows
Threshold Bit Score: 183.003
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006625378    1 MPQLN--------------GGGGDDLGANDEMISFKDEG-EQEEKISENVSAERDLDDVKSSLVNESEnnsS-----SSD 60  spotted gar
6_pfamImport    1 MPQLN--------------GGGGDDLGANDEMISFKDEG-EQEEKISENVSAERDLDDVKSSLVNESE---S-----SSD 57 
13_pfamImport   1 MPQLN--------------GGGGDDLGANDEMISFKDEG-EQEEKISENVSAERDLDDVKSSLVNESEnnsS-----SSD 60 
XP_005458373    1 MPQLS--------------REDGDDLGASDELIAFKDEG-EQEEK--RNVSAERDLDDVKSSLVNESEtnsS-----SDS 58  Nile tilapia
12_pfamImport   1 MPQLN--------------GEDGDDLGANDELIAFKDEG-EHEEK--RNVSAERDLDDVKSSLVNESEtnsS-----SDS 58 
8_pfamImport    1 MPQLN--------------GEDGDDLGANDELIAFKDEG-EHEEK--RNVSAERDLDDVKSSLVNESEtnsS-----SDS 58 
2_pfamImport    1 -------------------AGGGDDLGANDELITFQDEGsEEQEPSSDSASAQRDLDEVKSSLVNESEn-qS-----SSS 55 
XP_003224258    1 MPQLQpdpgaaersrdgggGGSGDDLGAPDELIPFQDEGdEQDKGAGGRGSAHGDLDELKSSLVHESEsrgAgggggSSS 80  green anole
5_pfamImport    1 MPQLN--------------GGGGDDLGANDELISFKDEG-EQEEKSSENSSAERDLADVKSSLVNESEtnqN-----SSS 60 
1_pfamImport    1 MPQLN--------------GGGGDDLGANDEMISFKDEG-EQEEKISENSSAERDLADVKSSLVNESEtnqN-----SSS 60 
XP_006625378   61 SEQAeRRPQPRQDSESY-EKPRdyf---teaLRRQQDGGFFKSP--SYPGYPFLMIPD---LTNPYLSNGSLSP-SARTy 130 spotted gar
6_pfamImport   58 SEQAeRRPQTRADSESY-DKARdyf---seaLRRQQDGGFFKSP--HYPGYPFLMIPD---LTNPYLPNGSLSP-SARTa 127
13_pfamImport  61 SEQAeRRPQTRPDSESY-EKTT---------LRRQQDGGFFKSP--HYPGYPFLMIPD---LTNPYLSNGSLSP-SARTt 124
XP_005458373   59 EAD--RRPEPRPGVESRaRQNQvce---ealRKQQRDGRLLQPS--PYVGYPFFMFPDlgnLCSPYLANGALTAgartyl 131 Nile tilapia
12_pfamImport  59 EVQGgRRSKAAVDLERRaRNGFp-------vFRRRQDGGLFHPS--PYVGYPFFMIPDlgnFCSPYLPNGALTPnartyl 129
8_pfamImport   59 EVPGdRRPKPGVDLERRaRHGQlld---edvFRRRQDGGLFHPS--PYVGYPFFMIPDlgnFCSPYLPNGALASn----- 128
2_pfamImport   56 DSEAeRRPQPP--RDPF-QKPReyf----aeVRRPQDGAFFKGP--PYPGYPFLMIPD---LSSPYLPNGPLSPgGARTy 123
XP_003224258   81 ESEAeRPPPPPRPRESF-QKPRdspasvaevLRRQQDGGFFKGT--PYPSYPFLMIPE---LGSPYLQSGALSPgGARTy 154 green anole
5_pfamImport   61 DSE-----------------------------------LHFQSGstHYSAYKTIehqiavqylqmkwplldvqag----- 100
1_pfamImport   61 DSEAeRRPPPR--SESFrDKTResl----eeAAKRQDGGLFKSP--PYPGYPFIMIPD---LTSPYLPNGSLSP-TART- 127
XP_006625378  131 lqmkwplldvpgt---------------------------aglkdsrsptpghlSNKVPVVQHPHHVHPLTPLITYSNEH 183 spotted gar
6_pfamImport  128 cisiqsvegkckcfcnyrqylqmk------wplldvpgsaglkdsrsptpghlqSNKVPVVQHAHHVHPLTPLITYSNEH 201
13_pfamImport 125 athfsnaacafsaynrleihlakqylqmkwplldvpgsaglkdsrsptpghlvkSNKVPVVQHAHHVHPLTPLITYSNEH 204
XP_005458373  132 pfqwplldv------------------------------pgrasvrdtatpshlSSSVPMVQHPHVSH-LHPLLSYSPEA 180 Nile tilapia
12_pfamImport 130 pfqwplldv------------------------------aarsairdatnpahlSNNVPVVQHPHMTH-LHPLLSYSPEA 178
8_pfamImport  129 ------------------------------------------------------PNNVPMVQHPHMTH-LHPLLSYSPEA 153
2_pfamImport  124 lqmkwplidvpst---------------------------ttvkdtrspspahlSNKVPVVQHPHHMHPLTPLITYSNDH 176
XP_003224258  155 lqvkwplldvpag---------------------------atlkdtrspspahlSNKVPVVQHAHHMHPLTPLITYSNDH 207 green anole
5_pfamImport  101 ----------------------------------slqsrqalkdarspspahivSNKVPVVQHPHHVHPLTPLITYSNEH 146
1_pfamImport  128 ------------------------------------------------------SNKVPVVQHPHHVHPLTPLITYSNEH 153
XP_006625378  184 FSPG-TPPSHLSPEIlDPKT-G-------IPRAPHPSELSPYYPLSPGAVGQIPHPLGW 233 spotted gar
6_pfamImport  202 FSPG-TPPSHLSPEIlDPKT-G-------IPRTPHPSELSPYYPLSPGAVGSIAHPLGW 251
13_pfamImport 205 FSPG-TPPSHLSPEIlDPKT-G-------IPRTPHPSELSPYYPLSPGAVGSIAHPLSW 254
XP_005458373  181 FSPPrASPGF------SPEAaG-------VSRSPHAS----CYPVSPGAMPQIPHPLGW 222 Nile tilapia
12_pfamImport 179 FSPQrASPGF------SPDT-G-------VSRSPHAA----CYPVSPGGMAQITHPLGW 219
8_pfamImport  154 FSPQrASPGF------SPDT-GtqhsincISRSPHTA----CYPVSPGGMAQITHPLGW 201
2_pfamImport  177 FSPG-SPPAHLSPEI-DPKT-G-------IPRPPHPAELSPYYPLSPGAVGQIPHPLGW 225
XP_003224258  208 FSPG-SPPSHLSPEI-DPKT-G-------IPRPPHPSELSPYYPLSPGAIGQIPHPLGW 256 green anole
5_pfamImport  147 FTPG-NPPPHLPADV-DPKT-G-------IPRPPHPPDISPYYPLSPGTVGQIPHPLGW 195
1_pfamImport  154 FTPG-NPPPHLQADV-DPKT-G-------IPRPPHPPDISPYYPLSPGTVGQIPHPLGW 202
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