5ZB9,3QM0


Conserved Protein Domain Family
HAT_KAT11
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pfam08214: HAT_KAT11 (this model, PSSM-Id:369758 is obsolete and has been replaced by 400497)
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Histone acetylation protein
Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation. Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin. KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast. This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11.
Links
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Statistics
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PSSM-Id: 369758
Aligned: 27 rows
Threshold Bit Score: 263.466
Created: 3-May-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5ZB9_A       9 LGDSLAKV--LPTGVKVTIRHISSAPSPCVALFAAPpGE------EPEsTFCENHFLAVSISPneneeseVIIFGIEVLV 80   Aspergillus fumi...
Q6FVT3       2 LQAILKEV--LPQDSSFEILHLQSPPSE-SAPLVN---NtskqnrAT--TIKTEHLFCLAYKG-------RIFYGLELYV 66   [Candida] glabrata
EDO17576     3 INSYLKDA--LPENENFELLHILSVPKE-THPIVTQnIStr--rdSKNvTIKTQHFFSLFYHS-------KVIFGLEVYV 70   Vanderwaltozyma ...
Q4S4B6    1327 VNDFLKRQs-NPESGDVTIRVVHVSDKVVEVKPGMKsRFvdsgemSESfPYRTKALFAFEDIDgv----dVCFFGMHVQE 1401 spotted green pu...
Q29FY0    1693 VNNFLKKK--EAGAGEVHIRVVSSSEKCVEVKPGMRrRFveggdmMNEfPYRAKALFAFEEVDgi----dVCFFGMHVQE 1766 Drosophila pseud...
Q8MTV9    1239 VNNFLRKK--DSGAGEVTIRVLSSYDKMTEVKPLMKkRFgn--dmEDSyPYRAKAMFAFEEIDgv----dVCFFGMHVQE 1310 California sea hare
EDO40753   924 VNTFLQKQg---cPAEVTIRVVSSVQKQAEIKPGMKtRYegsgqlPEYfPYQAKALFAFEEIDgt----dVCFFGMHVQE 996  starlet sea anemone
Q2VJ10     952 VNDFLKKK--EVGTGEVTIRVLASSDKVVEVKPLMRaRFtesgelSESfPYRLKAVFAFQEIDgq----dVCFFGLYVQE 1025 Schistosoma mansoni
Q1RLD3     493 VNSYLKRHdtNNEAGYIHIRSVYSGEKTVEVKPGMKsKFvdskemPETfPYKAKAFFAFEEIDgv----dICFFGVHVQE 568  vase tunicate
NP_013099    3 LNDFLSSV--LPVSEQFEYLSLQSIPLE-THAVVTPnKDdk---rVPKsTIKTQHFFSLFHQG-------KVFFSLEVYV 69   Saccharomyces ce...

5ZB9_A      81 YGT------------AHLTTIFVSKADSTGYLHLlKnapkvSLLRLISNAFLSFLVQTHQRPGVRLM------------- 135  Aspergillus fumi...
Q6FVT3      67 YITcnhd----neveKTERLVFVSKADTNGYCDI-R-----VNIKLVTLQLIRYVLSINPDYYLHRVipkerdykksgrt 136  [Candida] glabrata
EDO17576    71 YITlynstidshpklDAERLIFISKADTSGYSDI-R-----VNVKDITNSILSYLLSIDPNFYLKNVkpiqrkrdiytkq 144  Vanderwaltozyma ...
Q4S4B6    1402 YGSdc--------pqPNQRRVYISYLDSVHFFKPrC-----LRTAVYHEILIGYLEYVKKLGYTTGHi------------ 1456 spotted green pu...
Q29FY0    1767 YGSec--------paPNTRRVYIAYLDSVHFFRPrQ-----YRTAVYHEILLGYMDYVKQLGYTMAHi------------ 1821 Drosophila pseud...
Q8MTV9    1311 YGSsc--------pgPNTRRVYISYLDSVHFFKPrH-----LRTAVYHEILIGYLEYAKTLGYTTAHi------------ 1365 California sea hare
EDO40753   997 YGSdc--------qqPNTRRVYVSYLDSVHFFQPrQ-----LRTAVYHEILIGYLEHVGQIGFQMAHi------------ 1051 starlet sea anemone
Q2VJ10    1026 YGSes--------pqPNRRRVYVAYLDSVFFFRPkQ-----YRTDVYHEILVGYLLYAKRCGYAMAHi------------ 1080 Schistosoma mansoni
Q1RLD3     569 YGSda--------piPNQRRVYLSYLDSVHFFRPrH-----LRTAVYHEILIGYFEYCKNLGYEFAHi------------ 623  vase tunicate
NP_013099   70 YVTlwd-------eaDAERLIFVSKADTNGYCNT-R-----VSVRDITKIILEFILSIDPNYYLQKVkpairsykkispe 136  Saccharomyces ce...

5ZB9_A     136 ----------------------------------------------------VSLFARAQNQYLF---PGSIENPEKHVL 160  Aspergillus fumi...
Q6FVT3     137 nlitkatnsrkalkila-----drlqnhnliepeifnafytkfhsgkelvtkIALFTRPADQYLF---PNSSKNPNKHNL 208  [Candida] glabrata
EDO17576   145 lilgststrkglkilsn-----rrrkgfrldnekinknlfshftcnqniitkITLFTRPSEQYLF---SKSSESGNKHIL 216  Vanderwaltozyma ...
Q4S4B6    1457 ----------------------------------------------------WACPPSEGDDYIFhchPADQKIPK---- 1480 spotted green pu...
Q29FY0    1822 ----------------------------------------------------WACPPSEGDDYIFhchPTDQKIPK---- 1845 Drosophila pseud...
Q8MTV9    1366 ----------------------------------------------------WACPPSEGDDYIFhchPPEQKIPK---- 1389 California sea hare
EDO40753  1052 ----------------------------------------------------WACPPSEGDDYIFhchPPEQKIPK---- 1075 starlet sea anemone
Q2VJ10    1081 ----------------------------------------------------WACPPGEGDDYIFhmhPTEQKIPK---- 1104 Schistosoma mansoni
Q1RLD3     624 ----------------------------------------------------WACPPSEGDDYVFhchPPEQKIPK---- 647  vase tunicate
NP_013099  137 lisaastpartlrilarrlkqsgstvlkeiesprfqqdlylsftcpreiltkICLFTRPASQYLF---PDSSKNSKKHIL 213  Saccharomyces ce...

5ZB9_A     161 DDRGLIKWWCRVIDPILreyepetgshekavddqtqesaksSA-TAFLIVPGCDKFETRGFFPITarsdgkDRprWLNSY 239  Aspergillus fumi...
Q6FVT3     209 DGDGLLKWWASLLDNLLvsd------------------fnlNKtKAKIRIPGEDKYRFRRYTNAL------KCgiWTHGD 264  [Candida] glabrata
EDO17576   217 AGSTLLKWWISLIDKNIlhn------------------fkqDT-KAAMQIPGESSLEIKRYFKSL------LYpnWQVGD 271  Vanderwaltozyma ...
Q4S4B6    1481 -PKRLQEWYKKMLDKAV---------------------------SERIVHDYKDIFKQ-----AT------EDrl----- 1516 spotted green pu...
Q29FY0    1846 -PKRLQEWYKKMLDKGM---------------------------IERIIQDYKDILKQ-----AM------EDkl----- 1881 Drosophila pseud...
Q8MTV9    1390 -PKRLQEWYKKMLDKAI---------------------------IDRVVVDYKDIFKD-----AI------DSgi----- 1425 California sea hare
EDO40753  1076 -HKRLVDWYKKMLDKAI---------------------------MDKVVIEYKDILKQ-----AS------DDgl----- 1111 starlet sea anemone
Q2VJ10    1105 -AKRLQEWYRRMLQKAI---------------------------IEGIVVDYKNILKD-----AL------DHql----- 1140 Schistosoma mansoni
Q1RLD3     648 -PKRLQEWYKKMLDKAI---------------------------VDQVVLEYKDIYKQ-----AK------DDrl----- 683  vase tunicate
NP_013099  214 NGEELMKWWGFILDRLLiec-------------------fqNDtQAKLRIPGEDPARVRSYLRGM------KYplWQVGD 268  Saccharomyces ce...

5ZB9_A     240 PLHQLCDNpnapPRCLVPRFPDDPXTRFLIDLDDElpestgaagskensGHWRSVkSLAQFWEMMSFRQECSAGRLVGFL 319  Aspergillus fumi...
Q6FVT3     265 IFSDNDSDs---VIKCIPMFPDDPKSRFMKQLFEE--------------NRIQTT-SLDTFWTELQERQEFKLSVVVSVM 326  [Candida] glabrata
EDO17576   272 IFGGTDTSl---AVYKIPLFPDDPKSRFIRQLVEE--------------GRILSV-KLSTFWTELQERQEFRLSETVSVI 333  Vanderwaltozyma ...
Q4S4B6    1517 -----------tSAKELPYFEGDFWPNVLEESIKE----------------------LEQEEEERKREENSTCSESIDD- 1562 spotted green pu...
Q29FY0    1882 -----------gSAAELPYFEGDFWPNVLEESIKE----------------------LDQEEEEKRKQAEAAEAAAAANL 1928 Drosophila pseud...
Q8MTV9    1426 -----------sSAKDLAYFEGDFWPNVIEESIKE----------------------LDQEEEEKRRREEAEAAAAEAEA 1472 California sea hare
EDO40753  1112 -----------tNPKELPYFDGDFWPNALEDSIRE----------------------LDQEEEE-RKANAAAAEASGKEG 1157 starlet sea anemone
Q2VJ10    1141 -----------vSPTEIPYFEGDFWPNTLEDILKE----------------------LEEEEAR-RRREEAMAQAEAEDD 1186 Schistosoma mansoni
Q1RLD3     684 -----------qAARELPYFEGDFWPNVLEESIKE----------------------LEQEEED-RKQAEANEQAAAEEV 729  vase tunicate
NP_013099  269 IFTSKENSl---AVYNIPLFPDDPKARFIHQLAEE--------------DRLLKV-SLSSFWIELQERQEFKLSVTSSVM 330  Saccharomyces ce...

5ZB9_A     320 WLv----------------iNP--PGLVNS---VQMTSSRVA-SRD 343  Aspergillus fumigatus Af293
Q6FVT3     327 GIsgiyeidtn-ykpstdvyRC------RSkrqFHCIKNYIT-GEE 364  [Candida] glabrata
EDO17576   334 GIegylsklpiyipgtddiiIS------GSknkFNRIKSYIT-GEE 372  Vanderwaltozyma polyspora DSM 70294
Q4S4B6    1563 --------------------TKsdSKNAKKknnKKTSKNKSSlSRA 1588 spotted green pufferfish
Q29FY0    1929 FSiedn-----------evsGD--GKKKGQkkaKKSNKSKAA-QRK 1960 Drosophila pseudoobscura
Q8MTV9    1473 QDtveettd-----avcsdvAGtkKGEKKGqrnKKANKSKGS-ARK 1512 California sea hare
EDO40753  1158 ---------------------SkvKGNSKRsnsKKGTKSKAG-SRK 1181 starlet sea anemone
Q2VJ10    1187 EAdcssstne--glpgdpdkRSgkKKAKKRkgnKKGNTSTAS-KRK 1229 Schistosoma mansoni
Q1RLD3     730 gs-----------------wAPqtRRTIKNrrqRKQPQRKLS-QRS 757  vase tunicate
NP_013099  331 GIsgyslatpslfpssadviVP------KSrkqFRAIKKYIT-GEE 369  Saccharomyces cerevisiae S288C
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