6DU8,5MKE


Conserved Protein Domain Family
PKD_channel

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pfam08016: PKD_channel (this model, PSSM-Id:369653 is obsolete and has been replaced by 462341)
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Polycystin cation channel
This family contains the cation channel region of PKD1 and PKD2 proteins.
Statistics
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PSSM-Id: 369653
Aligned: 13 rows
Threshold Bit Score: 414.448
Created: 21-Mar-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6DU8_A  146 VSFQAISSMADFWDFAQGPLLDSL-----YwtkwyNNQSlghgshsfiyyeNMLLGVPRLRQLKVRNDs--cVVHEDFRE 218  human
O08852 3702 QAFLAITRSDEFWPWMSHVFLPYV-----H-----GNQS------------SPELGPPRLRQVRLQEA----FCPDPSSS 3755 house mouse
Q95V80 2212 KDYHLMNDFRSFLKWADSTLLPGL-----L-----SENRwgae-----kqsTLIGGGLRLRQVRVKPSs--cETHPLFVD 2274 purple sea urchin
Q9VK95  403 SGNYLKDDSDSI-----------------Q-----ANMSfhhlegrvflyeNLLLGPPRLRQIRVRKEs--cYVNDAFIR 458  fruit fly
Q9U1S7  120 PAFGSCTSMDNIWDWLSQVLIPGIyw-teT-----SNSTdnenm---iyyeNRLLGEPRIRMLKVTNDs--cTVMKSFQR 188  Caenorhabditis elegans
O35245  266 TNFKTLSSMEDFWKFTEGSFLDGLywkaqT-----SNHTqadnrs-fifyeNLLLGVPRLRQLRVRNGs--cSIPQDLRD 337  house mouse
A2A259  146 vSFQTISSMSDFWDFAQGPLLDSLywtkwY-----NNQSlgrgshsfiyyeNLLLGAPRLRQLRVRNDs--cVVHEDFRE 218  house mouse
Q8T8Z2  170 FGLSQVYFIYQVHSYMKITLVEAF-----Y-----AQKTngyegw-wameqWQKIGVVRLRQMRPVD------------- 225  fruit fly
Q9VVZ8  166 FGLLSVGDVPDIYFFVVSSLVLAF-----T-----DGKNtsggapwihaegTRLLGVVRLRQLRTES------------- 222  fruit fly
Q9W4X5  170 TGLQEVYFLNQLFDFIESTLVLAF-----N-----SNSTesgspgwahaeqSVLLGVMRLRQLRVSN------------- 226  fruit fly
Q9NTG1 1749 MDLATVTKLEDIYRWLNSVLLPLL-----H-----NDLNptfl----pessSKILGLPLMRQVRAKSSekmcLPAEKFVQ 1814 human
Q9Z0T6 1622 VDLATVMKLGDIYTWLHGVFLPLL-----H-----NDPNptfl----pdssSKILGLPLVRQVRARPSnktcLLAKKFVQ 1687 house mouse
5MKE_A  268 TNFKTLSSMEDFWKFTEGSLLDGL-----YwkmqpSNQTeadnrs-fifyeNLLLGVPRIRQLRVRNGs--cSIPQDLRD 339  human
6DU8_A  219 DILs----CYDVYSPDKEEq-----------LPFGPFNGTAWTYHS-----------QDELg-------------GFSHW 259  human
O08852 3756 EHM-----CSAAGSLSTSDygi-------gwQSVVQNGSETWAYSA-----------PDLL--------------GAWYW 3798 house mouse
Q95V80 2275 LINd----CRALFTPESEDrelyn---aswsQPIVNMSALLNSSQT-----------VEEWslsnyspwhfypdkAVGMW 2336 purple sea urchin
Q9VK95  459 YFNt----CYAAYSSGAEDr-----------KPMHKGSP----FRT-----------MHDLd-------------STPIW 495  fruit fly
Q9U1S7  189 EIKe----CFANYEEKLEDk-----------TMVGDGSVDAFIYAT-----------AKELe-------------NLKTV 229  Caenorhabditis elegans
O35245  338 EIKe----CYDVYSVSSEDr-----------APFGPRNGTAWMYTS-----------EKELn-------------GSSHW 378  house mouse
A2A259  219 DILn----CYDVYSPDKEDq-----------LPFGPQNGTAWTYHS-----------QNELg-------------GSSHW 259  house mouse
Q8T8Z2  226 --------CHIGLGKPEWDkktyapewrlpyHRMHYTEKFWRIYDPfvpaefepsflNGLLl-------------NYDHY 284  fruit fly
Q9VVZ8  223 --------NRLGLSLPVFTerdfseswtlpyERVPYTDKYWPIYTPwlpsv--svarDNLLm-------------GINHV 279  fruit fly
Q9W4X5  227 --------PQVGLGPPKFSdtyympdwqlpyRKLHYSDKYWRIYEPwipikmgfeflDALLm-------------NFDHV 285  fruit fly
Q9NTG1 1815 NSIrreihCHPKYGIDPEDtknysgfwnevdKQAIDESTNGFTYKP-----------QGTQw-------------LYYSY 1870 human
Q9Z0T6 1688 SSVageihCHPQYGIDPEDtqhyssvwskagKQSTDKASHGFTYKP-----------PGKRw-------------VYHSY 1743 house mouse
5MKE_A  340 EIKe----CYDVYSVSSEDr-----------APFGPRNGTAWIYTS-----------EKDLn-------------GSSHW 380  human
6DU8_A  260 GRLTSYS-GGGYYL-DLP-GSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQI 336  human
O08852 3799 GYCAVYD-SGGYIQ-ELG-LSLEESRARLGFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSV 3875 house mouse
Q95V80 2337 GHATSLP-SSGYIW-VLG-SMYEEAKDSLAEMVDARWLDARTRALFVEWTSYNANTNLFCVVTFLMETPASGGLLKLPEV 2413 purple sea urchin
Q9VK95  496 TVLAFYR-TGGYTV-NLD-YDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHL 572  fruit fly
Q9U1S7  230 GTIASYG-GGGFVQ-RLPvAGSTEAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGGVITTPKL 307  Caenorhabditis elegans
O35245  379 GIIASYS-GAGYYL-DLS-RTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLAEFPATGGVVPSWQF 455  house mouse
A2A259  260 GRLTSYS-GGGYYL-DLP-GSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQI 336  house mouse
Q8T8Z2  285 GYLLNYPeVAGYVV-LMM-STKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHV 362  fruit fly
Q9VVZ8  280 GHMFNYPeSKGYKV-LLS-DTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRI 357  fruit fly
Q9W4X5  286 GSLNSYPeLAGYVS-LLA-RSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQV 363  fruit fly
Q9NTG1 1871 GLLHTYG-SGGYALyFFPeQQRFNSTLRLKELQESNWLDEKTWAVVLELTTFNPDINLFCSISVIFEVSQLGVVNTSISL 1949 human
Q9Z0T6 1744 GVLNTYG-SGGYVFyFFPgQQMFNSTVRLKELEGKNWLDELTWAVIVELTTLNPDTSLMCSISVVFEVSPLGVVNSSLSV 1822 house mouse
5MKE_A  381 GIIATYS-GAGYYL-DLS-RTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQF 457  human
6DU8_A  337 RTVKLIRYVSNWDFFIVGcEVIFCVFIFYYVVEEILELHIHR-LRYLS-SIWniLDLVVILLSIVAVGFHIFRTLEVNRL 414  human
O08852 3876 RPFALRRLSTGLSLPLLT-SVCLLLFALYFSMAEVQTWRKDGcACTARpDTW--ARCLLVILTAATGLVRLAQLGIADRQ 3952 house mouse
Q95V80 2414 QAVRLHRYAANYKLFVILcEILFVVALFFVMYREYVRYKPIGiRKYLS-DKWnlLEIAIIVNCIVSAGLYIYRYVITKQL 2492 purple sea urchin
Q9VK95  573 QTVKMYSFFTDRSMLMTViYIFWYIMVIYYTIYEITEIRKSGiKIYFC-SMLniLDCAILLGCYLALVYNIWHSFKVMSL 651  fruit fly
Q9U1S7  308 MTYDLLTYQTSGGTRMMIfEGIFCGFILYFIFEELFAIGRHR-LHYLT-QFWnlVDVVLLGFSVATIILSVNRTKTGVNR 385  Caenorhabditis elegans
O35245  456 QPVKLIRYVTAFDFFLAAcEIIFCFFIIYYVVEEILEIRIHR-LSYFR-SFWncLDVVIVVLSVVAMVINIYRMSNAEGL 533  house mouse
A2A259  337 RTVKLIRYVNNWDFFIVGcEVVFCVFIFYYVVEEILEIHLHR-LRYLS-SVWniLDLVVILLSIVAVGFHIFRTLEVNRL 414  house mouse
Q8T8Z2  363 DSVSMLGNVETRSNSELLiLFVYTVLVILFARGVFTKIWHH--PAAAH-EAWtmVDLAIYILNVFLTVLAIMRDIETDAL 439  fruit fly
Q9VVZ8  358 ESHTFVEQLREFTKFGMLmVFVFVVTWLQFTKAFFLKVWYD--PRQLK-TLWvqVDAMIVALSLVVGMIMSVRDNLVQKM 434  fruit fly
Q9W4X5  364 DSAKLLENVDQMPYTGLLaLLIYVLVFIQFAQTLAVKLWYE--PHLLK-SVWnkLDLFIFMVNVLVVVLVVLRESLVASM 440  fruit fly
Q9NTG1 1950 HSFSLADFDRKASAEIYL-YVAILIFFLAYVVDEGCIIMQER-ASYVR-SVYnlLNFALKCIFTVLIVLFLRKHFLATGI 2026 human
Q9Z0T6 1823 YSFSLADFNRKTSSEIYL-YAAILIFFCAYVVDEGYIIRQER-ASYIR-SVYnlLNFSLKCMFALLIVLFFWKYFLATKM 1899 house mouse
5MKE_A  458 QPLKLIRYVTTFDFFLAAcEIIFCFFIFYYVVEEILEIRIHK-LHYFR-SFWncLDVVIVVLSVVAIGINIYRTSNVEVL 535  human
6DU8_A  415 MGKLL-QQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQ 493  human
O08852 3953 WTHFVqDHPRHFTSFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQ 4032 house mouse
Q95V80 2493 FKQMR-DESVRFVGFRTAATSDNALGYSLAVIIILSCVKFLYLLRLNPRMYLLTSVISDCYHEVIAFTFLIFILILSFAF 2571 purple sea urchin
Q9VK95  652 TARA--HSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQ 729  fruit fly
Q9U1S7  386 VNSVI-ENGLTNAPFDDVTSSENSYLNIKACVVFVAWVKVFKFISVNKTMSQLSSTLTRSAKDIGGFAVMFAVFFFAFAQ 464  Caenorhabditis elegans
O35245  534 LQFL--EDQNSFPNFEHVAYWQIQFNNISAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFSIIFLAYAQ 611  house mouse
A2A259  415 MGKLL-QQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQ 493  house mouse
Q8T8Z2  440 LQIIEtATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGI 519  fruit fly
Q9VVZ8  435 IKSVEiAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGI 514  fruit fly
Q9W4X5  441 MKKVEgASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCF 520  fruit fly
Q9NTG1 2027 IRFYL-SNPEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMA 2105 human
Q9Z0T6 1900 VQLYL-ADPEAFIPFHAVSRVDHFMRIILAFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTALVVSIYSFMYVA 1978 house mouse
5MKE_A  536 LQFLE-DQ-NTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQ 613  human
6DU8_A  494 LGYLLFGTQVENFSTFIKCIFTQ-----FRIILGDFDYNaidn------anriLGPAYFVTYVFFVFFVLLNMFLAIIND 562  human
O08852 4033 MAILLISSGADTLYNMARAFLVLcpgarVPTLCPSESWY--------------LSPLLCVGLWALRVWGALRLGAILLRW 4098 house mouse
Q95V80 2572 PMTIMFGSNLPDYRDITKTALNL-----FITLPDNFVYEdlks------vqrvLGPLILLLFQFLSCYLFLDLLIAALNE 2640 purple sea urchin
Q9VK95  730 LGLLLFGTKHPDFRNFITSILTM-----IRMILGDFQYNlieq------anrvLGPIYFLTYILLVFFILLNMFLAIIME 798  fruit fly
Q9U1S7  465 FGYLCFGTQIADYSNLYNSAFAL-----LRLILGDFNFSales------cnrfFGPAFFIAYVFFVSFILLNMFLAIIND 533  Caenorhabditis elegans
O35245  612 LAYLVFGTQVDDFSTFQECIFTQ-----FRIILGDINFAeiee------anrvLGPLYFTTFVFFMFFILLNMFLAIIND 680  house mouse
A2A259  494 LGYLLFGTQVENFSTFVKCIFTQ-----FRIILGDFDYNaidn------anriLGPVYFVTYVFFVFFVLLNMFLAIIND 562  house mouse
Q8T8Z2  520 TLAVPNGNNAVVFSHMVQSVVTC--------MWYSMGFNgdihpadffhggriLGILLYLALVFLLAIILMNVFASVIYD 591  fruit fly
Q9VVZ8  515 ATVTINGNYTSNFRDFPKGIVTV--------TCFAFGYTnlvyppdifyggewLGILLYTIMGFVVKYMLINLIVSMMRD 586  fruit fly
Q9W4X5  521 AVVTINGNYSSNFNKLVKSMVMC--------MCYSFGFSaqvkpselfhggkwLGILCYGVLAFVIIVLLINVFVSLIND 592  fruit fly
Q9NTG1 2106 FGYLVFGQHEWNYSNLIHSTQTV-----FSYCVSAFQNTefsn-------nriLGVLFLSSFMLVMICVLINLFQAVILS 2173 human
Q9Z0T6 1979 FGYLVFGQHEWNYSNMIHATQTI-----FSYCVSAFQNTefsg-------nkvLGVLFLSSFMLVMICIFINLFQAVILS 2046 house mouse
5MKE_A  614 LAYLVFGTQVDDFSTFQECIFTQ-----FRIILGDINFAeiee------anrvLGPIYFTTFVFFMFFILLNMFLAIIND 682  human
6DU8_A  563 TYSEV 567  human
O08852 4099 RYHAL 4103 house mouse
Q95V80 2641 SMVTI 2645 purple sea urchin
Q9VK95  799 TYNTV 803  fruit fly
Q9U1S7  534 SYVEV 538  Caenorhabditis elegans
O35245  681 SYSEV 685  house mouse
A2A259  563 TYSEV 567  house mouse
Q8T8Z2  592 YFNET 596  fruit fly
Q9VVZ8  587 QMASV 591  fruit fly
Q9W4X5  593 YFTva 597  fruit fly
Q9NTG1 2174 AYEEM 2178 human
Q9Z0T6 2047 AYDEM 2051 house mouse
5MKE_A  683 TYSEV 687  human
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