Conserved Protein Domain Family
LETM1

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pfam07766: LETM1 (this model, PSSM-Id:369505 is obsolete and has been replaced by 462258)
LETM1-like protein
Members of this family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.
Statistics
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PSSM-Id: 369505
Aligned: 147 rows
Threshold Bit Score: 177.691
Created: 4-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH63189       37 LGRRIRKEITHYINGTKLLANELSDSVKLVVRMTQ-GDH----MKRRELIQLRKTADDLFRLLPFSAFII-IPFAELLLP 110 Tetrapisispora...
EFN87522       69 KFPRTMQVYRVFSVGSRDVYADLKRFVSAIKKQGSnGIDs---LTRKELQLMHMMPRDLRKLTPLFLLSA-IPFTNYIIF 144 Jerdon's jumpi...
XP_001605931   73 NFPKTMHVYRVFSIGSKEFYADLKRYMQVRKKIRNfGADt---LNREELQLTFTFPKDLIKISPVLLISA-VPFTNYIIF 148 jewel wasp
EFA01050       73 SFPGAMRVYRVFTVGIKDFAQDLKDYFRIVRILNSpTKDkfksLTRREIELYHQMPKDMRKVAPVLLISA-LPFANYVIF 151 red flour beetle
EDX09734      148 NFPKAMQLYRVFFDGVKDFFGDMKRFLKIARIANDsPQGir-aLNRQELELYMQMPRDMMKVAPALIGCS-LPMVGYAFF 225 Drosophila sim...
Q0IG76         85 KFPSAMHVYRVFLVGVKEFFNDMKKLVKITKIVYThDNDlr-cLTRKEIELYYQMPRDMKKVAPVLLVSA-LPFANYVVF 162 yellow fever m...
Q7Q6P8         96 KFPSAVHVYRVFLVGVRDFFNDMKKLVKITKIVYShDNDlr-cLTRKEIELYYQMPRDMRKVAPVLLISA-LPFANYVIF 173 Anopheles gamb...
24_pfamImport   1 WSPSTAKYARLSVFGCKYLYKDVLVLLSAYKKYYSsDLSs---LTYAELELKYRLPLQLVRLTPILIFWP-VPFTNLFLF 76 
EEB19190       21 MFPTAVKIYQDFSVGLKFLKSDFITLFRAFKKITScGLNs---LTRKELEVYYELPKDILRTAPVIFIGAvVPFGG-IIF 96  human body louse
EDO43880       70 rIQHFRKVMNQFVVGSKSLGSDVKRMVGIRRKLKEhGYNwd-aLTADETLHMTQVRQDLIKTLPAVLVFC-IPFLGYAAP 147 starlet sea an...
CCH63189      111 FCLKLFPN-LLPSTYETGDNKMLKL----IRLAENKSIISSLL--RNTLndsklniplynnhSKQIAT---NKEIFNKFF 180 Tetrapisispora...
EFN87522      145 PLVLYFPRyLLTSHFWTLQQKLEFMlhdhKRRLRHNRPLFRCM--QAEL-------------KTIGDQt--LRIKWRDVI 207 Jerdon's jumpi...
XP_001605931  149 PLAFYFPHvLLTSHYWSIEDKLNFMlkehKKRLQHNKPLLRCV--QSQV-------------KTIQDTe--SRATFKNII 211 jewel wasp
EFA01050      152 PLAYLFPRiFLSRHFWNLQQRAEFSiyylRGRLVNNRPLFRCV--QGEL-------------DKIRGHr--LYYKWAEVL 214 red flour beetle
EDX09734      226 PLVFYYPRsFLTAHFWTPQQRSEFQsyymKRRLCNNKDVFRCL--QAKL-------------KATASHp--KHSAFAEIL 288 Drosophila sim...
Q0IG76        163 PLAYMYPRtFLTPHFWSIQQKVDFAqqdlKHRLQYNRRVFRCM--QAKL-------------DVMRKNndpLCEQFGNIL 227 yellow fever m...
Q7Q6P8        174 PLAYMYPRtLLTSHFWSAQQKLDFVqidlRNRLLYNRRVFRCM--QSKL-------------DALKKThdpAYEKFAYML 238 Anopheles gamb...
24_pfamImport  77 PLAFMFPKyLLSEHFWTDEQLKEYWikdqQNNFEHNMRVFEHL--SLMA-------------EECSDD---MLLKWFRVI 138
EEB19190       97 ILGYYFPKhLLTHHFWSQQQQNEFSslkhKKTISSYTPVYNCL--ESRL-------------SVIKDTd--LCLKMCNLL 159 human body louse
EDO43880      148 LIAFMYPKhLLSHHYWLPCQEQQFRdhdaLKRSNHYLPLVREVgrQALQ-------------EKRKDR---DLEDLLDVS 211 starlet sea an...
CCH63189      181 YRlkiLKRNGyslaitklsfhfTEHEVLQVAKLFKDD-TLLISLTKRQLSLLNQYMSlsLPSLGTMNLLKYRLRHTLNKI 259 Tetrapisispora...
EFN87522      208 AC---LGSGTh----------pTTNDIIACSVLFSGPpYSLDVLKRKHMKELLAIYG--MSSW--RLFKRKRLMERGMLI 270 Jerdon's jumpi...
XP_001605931  212 AC---LGSGTh----------pTIDDILYCKKLFSGPpYSLKCMKRKHVKELLKVHG--MSRF--SLGNRTRLLERGLLI 274 jewel wasp
EFA01050      215 GM---MGSGVq----------pKVEQILQCKDLFTCEpYHLFYLKGKHVKHLLKIHD--LHM---GWFRRSRLIERAVIL 276 red flour beetle
EDX09734      289 GQ---LGSGTh----------pTPEMLIDVKDIFADGpYSLLGMSRKHVRNLVNLHG--LPS---SIFKRHRLHEHAFLV 350 Drosophila sim...
Q0IG76        228 GL---LGSGLh----------pTSEEILNIRDLFSRPpLHLNNLSSVHLKYLCKLHD--LNA---GLMRRYRLSERSYIV 289 yellow fever m...
Q7Q6P8        239 GL---LGSGLh----------pTSEEILDVKEVFQRPpFHLNSLSSSHLKYLCRLHD--IHA---GLLRRFRLSERAYVV 300 Anopheles gamb...
24_pfamImport 139 EC---LGAGGv----------sPVDDIIQAIPVFTMFpYHFSTLPRQHIKVLLKMYN--IHR---GWRRRVRLKKLAQYI 200
EEB19190      160 EN---IKSNVh----------pNAKSILSVKSLFKGVpFGLNHMESYHISKLLNLYN--MHK---GWRRRERLYMRANLV 221 human body louse
EDO43880      212 LK---TINKKh----------pTNEELLKSSDKFSGV-LGFNSLPKYHLKRLSHAWL--LWPWLPRRLLRGNLRRKLASI 275 starlet sea an...
CCH63189      260 KKDDILIARE-GVTHLTDEELYEACMSRGIQIQhetdllthkSVMRKEMIKALENWLLLRLKHHIPMVLLIL 330 Tetrapisispora blattae...
EFN87522      271 LRMDRAIVREgGVKAMSNDAMRWALSFRGVNPT---------NMSTESMRSWLEQWLTVSASVDQKNISLLL 333 Jerdon's jumping ant
XP_001605931  275 KRMDTAIQREgGVTKLPYDAIRWALSFRGVNPV---------NMSTESMQAWLDQWLLISSQVDEGSISLLL 337 jewel wasp
EFA01050      277 QEMDKAIVREgGVHNMPQDALKHACYIRGLNPM---------NMRNEDMINWLNNWIKISSVVDRESWSLLL 339 red flour beetle
EDX09734      351 HYMDQAITREgGVHNLTPDALRYSCYLRGLNPD---------SLSSEAMIEWLRKWVKVSTSIQGEHITLFL 413 Drosophila simulans
Q0IG76        290 HHMDLAIKREgGVHNMPVESLKHACFVRGLNAT---------NLSTESMIDWLNEWVKVSLVVNQDNISMFL 352 yellow fever mosquito
Q7Q6P8        301 HHMDMAIKREgGVHNMPIESLKHACYLRGLNAN---------NLSAESMIEWLQEWVKVSLVVDEDCISMLL 363 Anopheles gambiae str....
24_pfamImport 201 QLMDRAIESEgGPDKLNDRQLKWACLFRGLSPF---------SSSRETLVLYLKDWIKISSKIDNDSLSCIL 263
EEB19190      222 KLMDLAIIKEgGPEILNLHDMRWHCFFRGLNPI---------NMNNDELLFWLRMWLEISREIDKNSYSLLL 284 human body louse
EDO43880      276 KKEDAALKRD-GLDSLDEIQIKRLCHCRGLQVQ---------SLEHEALKAWLTEWVELASHSSDHDdsfla 337 starlet sea anemone
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