Conserved Protein Domain Family
L6_membrane

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pfam05805: L6_membrane (this model, PSSM-Id:368620 is obsolete and has been replaced by 461745)
L6 membrane protein
This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family. Several members of this family have been implicated in human cancer.
Statistics
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PSSM-Id: 368620
Aligned: 105 rows
Threshold Bit Score: 103.015
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001509686   5 SCARCLGVTLIPLAVLGALANILLFFPGGKVID--DKENLSEEVWYFAGILGCGVLMIfPVLVFRGLKNND-Ccgccgnr 81  platypus
XP_852211      6 GWTSCNGFSLLVLLLFGIVLNAIPLIVNFVDEGqfFHNPISCFEWWFPGIIGAGLMVI-PAATMSLAARKRaC------- 77  dog
XP_001496704   6 GWTSCNGFSLLVLLVLGVILNAIPLIVSLVDADqvFQNPISCFEWWFPGIIGAGVMVI-PATSMSLAARKRaC------- 77  horse
XP_003417970   6 GWTSCNGFSLLVLLLLGIVLNAVPLIVSLVDEAqlLQNPISCFEWWFPGIIGAGAMVI-PATTMSLAARKRaC------- 77  African savanna...
ELW71251       6 GWTSCNGFGLLVLLLFGIVLNAVPLIVNLVEEDklFESPISCFEWWFPGIVGAGVMVI-PATTMSLAARKRgC------- 77  Chinese tree shrew
XP_006082666   6 GWTSCNGFSLLVLLLSGVALNAIPLIVNRLEEGefFKNPISCFEWWFPGIIGAGLMAI-PATTMSLAARKRaC------- 77  little brown bat
XP_003766182   6 GFTSCNGFSLMVLALLAVVLNTIPLISYKLQSDelSKNPISCFEWWYPGIIGAGVLVI-PATIMSLAARKRaC------- 77  Tasmanian devil
XP_001373711   6 GWTSCNGFSLLVLLILAIALNIIPLAVYTVERNekFRNPISCFEWFFPGVIGAGLLAI-PATVMTLSARKRnC------- 77  gray short-tail...
XP_003785119   6 GWTSCNGFGLLVLLLLGVILNAIPLVMNLLEQDqfFQNPISCFEGWFPGIIGAGLM------------------------ 61  small-eared galago
XP_003991271   6 GWTSCNGFTLLVLLLLGITLNAIPLIVNLVDEGqfLQNPISCFEWWFPGIIGAGLMVI-PATTMSLAARKRaC------- 77  domestic cat
XP_001509686  82 gCGKRFAMFSSIIFAGIGVLGAGYAFAVSVVSINRGPK-CMTNTNNt----WNypFLH-------------GNYLSDRSl 143 platypus
XP_852211     78 -CNNRTGMLLSSLLNVITIIGAVYCILVSIHALIEGPLiCNSEGNStsnceFS--FSNlsdth---peffnLQWFYKES- 150 dog
XP_001496704  78 -CNSKVGMFLSSLLNIITVIGAVYCMLVSIQALAEGPLiCNSQGNStssceFS--FKNlrdih---lesfnVRWFFNES- 150 horse
XP_003417970  78 -CNNKTGMFLSSLLNVVTVVGAVYCILVSTQALSEGPLfCNSPGNStfscqFS--WKNlsnih---pesfdLQWFFNDS- 150 African savanna...
ELW71251      78 -CNNKTGMFLSSLLNVITIIGAVYCMLVSIQALAKGPLiCNTPGNTnc--eFS--LKNlsdiq---pesfnLHWFFNDT- 148 Chinese tree shrew
XP_006082666  78 -CNNRGGMFLSSFLNIITILGAVFCVLVSLQALFKGPLiCNSPGNStc--eFS--VDKlriyp----qsfnLQWYFNGS- 147 little brown bat
XP_003766182  78 -CNNRLGMILSSFLSLVTIGGAVYCILVSALALSEGPLiCNYNGNStfnceFS--MKNlsdihdqlqqpitLRWFFSPT- 153 Tasmanian devil
XP_001373711  78 -CNNRFGMFLSSVLSLVTIGGAFYCMLTSLMALSEGPLiCNYHGNStvqcdLSmaMKNisnir----nqfdLQWFYFPT- 151 gray short-tail...
XP_003785119  62 -------MFLSSLFSVITILGAVYCMVVSLQALSEGPLvCSLPANSsaqceFS--FKNltnih---pesftLQWFYNNS- 128 small-eared galago
XP_003991271  78 -CNNRIGMLLSSLLNVITVIGAVYCMLVSLRALSEGPLiCNSQVNSts--sCEfsFNNlsnih---pesfnLQWFFRES- 150 domestic cat
XP_001509686 144 wdlCLSPK---------------------------NIVPWNLGLFSSLLIISAIQMVLCAIQVINGIFGTLCGDCQ 192 platypus
XP_852211    151 ---CIAPTdytnltvnsimpsgwrehslhfnskenKHRTIHLTVFLGLLLVGILELLVGFSQIVIGFLGCLCGVTK 223 dog
XP_001496704 151 ---CVTSTgfanptnndimas--nwgknslnstenKYRIIHFSVFLGLLLVGILELLFGLSQIVIGFLGCLCGVSK 221 horse
XP_003417970 151 ---CVPSTglsnsntasggs----kydqhinptenKYKIIHISAFTGLLLVGTLELLFALSQIVIGFLGCLCGGVs 219 African savanna ele...
ELW71251     149 ---CVPPGnsnipntnntwpsnwtaysldfsseedKRRIIHFATFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSR 221 Chinese tree shrew
XP_006082666 148 ---CVAPNslnssttndtma----sdlkkynlqekRHKTIHLSVFVGLLLVGSLELVCALSQIVIGFLGCLCGVSK 216 little brown bat
XP_003766182 154 ---C-EPEipnnsvpdnstnlfqrtntltvsseenRYKIIHLTVFVGLFLVGILEILFSISQIVIGLFGCLCGVSK 225 Tasmanian devil
XP_001373711 152 ---CQPgyrnssaidfntns--fqskgftfsseenRHRVIHFTVFAGLFLVAVLEIFFSFSQIVIGLYGCLLGVSK 222 gray short-tailed o...
XP_003785119 129 ---CLLPVlnnptf----------------sdttsQHTVIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSK 185 small-eared galago
XP_003991271 151 ---CMAPAevtdptlsgtrasdggryslnfsskenKHRTIHFSVFLGLLLVGILELMCGLSQMAIGLLGCLCGVTK 223 domestic cat
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