2D8R


Conserved Protein Domain Family
THAP

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pfam05485: THAP (this model, PSSM-Id:368467 is obsolete and has been replaced by 461662)
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THAP domain
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.
Statistics
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PSSM-Id: 368467
Aligned: 561 rows
Threshold Bit Score: 36.2241
Created: 17-Jun-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2D8R_A          12 CAAagCATtynkH--IN------ISFHRFPLDPkrrkEWVrlvrrkn--------------fvpgkhtFLCSKHFeascf 69   human
OCA38850         4 CIVkgCTN----Yg-QRktmfhnVILHVFPKNPniikTWLqqfpegfgdidtv--cqkiiagkktdayRICSEHFstdsy 76   tropical cla...
56_pfamImport    1 CLVkqCHS----Wt-GRkn--rnVILHVFPKNIsrvkEWLmkmqqystedievl-sqkilqtkkndnyRICSKHFtddsy 72  
60_pfamImport    1 CIVkqCHS----Wt-GRkkvkenVILHVFPKNFsrikEWLaktqqysaedievl-sqkimqtkkndnyRICSKHFtddsy 74  
66_pfamImport    1 CLVknCPH----Kt-GNkalypeVVLHVFPRNLdrikIWLnftgqdfpdfdgf--vqqifsskkidnyRICSVHFpetsy 73  
62_pfamImport    1 CLVhgCRH----St-ARkglypgIVLHGFPKNLsrikQWLlntgqnfgnldaf--aqkvldgkkhnsyRICSSHFssdcy 73  
53_pfamImport    1 CIVsrCPS----ScsNKqtkstgIVMHSFPCNLdrikNWLlnidqnfgnidtfasrileekkkhsdlyRLCSEHFtpesy 76  
XP_004911116     4 CIVkgCQN----St-RKngrqsgVRLHVFPSCPsrikLWLqqigqniqdldsf--tqrvmdqrkkgifRICSIHFtpdsy 76   tropical cla...
XP_002932689     4 CIVkgCRN----Ts-RKnkrdlgVTLHGFPCSIerikLWLqqigqdfgnldsy--aqkildtrkrnifRICSAHFepeny 76   tropical cla...
NP_001072457     4 CIVrsCPH----Ks-GKkiqypdVILHVFPKNFerikRWLqqtgqefkdldry--aqcileekkndnyRMCSDHFapecy 76   tropical cla...
2D8R_A          70 -dltgqTRrLKMDAVPTIF 87   human
OCA38850        77 cvqgnrWV-LRKDAIPTIF 94   tropical clawed frog
56_pfamImport   73 iikgdkKV-LLPSAVPTLF 90  
60_pfamImport   75 likgdkKV-LLPSAVPTLF 92  
66_pfamImport   74 ilkgtrRL-LRQDAMPTLQ 91  
62_pfamImport   74 vqlgctKG-LKADAVPTIF 91  
53_pfamImport   77 intgkrMS-LRPDAIPTVF 94  
XP_004911116    77 ildgekFI-LSKDAVPTIF 94   tropical clawed frog
XP_002932689    77 icqgmkLV-LRADAVPTIF 94   tropical clawed frog
NP_001072457    77 tfrgstKA-LREDAVPTIF 94   tropical clawed frog
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