Conserved Protein Domain Family
eIF_4EBP
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pfam05456: eIF_4EBP (this model, PSSM-Id:368450 is obsolete and has been replaced by 461656)
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.
Links
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Statistics
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PSSM-Id: 368450
Aligned: 46 rows
Threshold Bit Score: 112.335
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CDS30584        2 ASKDVP--LRRVKYSDRSQLPHDYSSTPGGSIFSTTPG---------GTRIYYDRDTLLMCKNSPIARSPPVG-MIC--- 66  Hymenolepis mi...
EDO31445       12 LARAIP--SRRVPVHDPNHMPSDYSTTPGGTIYSTTPG---------GTRIIYERKFLLELRNSPLAKSPPAN-LPV--- 76  starlet sea an...
ETN61553       14 ITQAIP--SKRVLIHDASELPDLYSSTPGGTLYSTTPGasrpssggpSTRIVYERAFLMNLKNSPLARTPPNN------- 84  Anopheles darl...
Q7PN41         14 ISQAIP--SKRVLIHDASELPDLYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPPNN------- 75  Anopheles gamb...
Q17JZ5         13 QTQAIP--SKRVLIHDASELPDLYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPPSN-LNN--- 77  yellow fever m...
EDW44619       11 ITQALPmiTRKVVISDPIQMPEVYSSTPGGTLYSTTPG---------GTKLIYERAFMKNLRGSPLSQTPPSN-VPScll 80  Drosophila sec...
EFA09088       12 ESKAIP--TKKVLINDPSELPSHYSSTPGGTLYSTTPG---------GTKIVYEKAFLMNLRNSPISKTPPSY-G----- 74  red flour beetle
12_pfamImport  10 MSQSIP--SKRILISDSSQLPIDYSTTPGGTLYSTTPG---------GTRIVYERSTLMFLRNSPLSQTPPN-------- 70 
EGG24685       11 TSRAIPfnVSRQDMI-------NFSTSLGGTLYGTTPG---------GTKLVYDKNTLLQYRNSPLAKTPP--------- 65  Cavenderia fas...
NP_001040409   12 HSQSIP--SRRVLITDPAQMPDVYSSTPGGTIYSTTPG---------GTRIVYERSFMLSLRQSPISQTPPQCaLPA--- 77  domestic silkworm

CDS30584       67 -------------RP-------GVTCPLNCHgdcnlskmpatdqksAQKTVVTPERLENQPPHK--EEEPFELDL 119 Hymenolepis microstoma
EDO31445       77 -------------IP-------GVTCedng------------kpepEEKPEVTSLPGARGEGDG--EEPQFQMDI 117 starlet sea anemone
ETN61553       85 -------------VPlnllranGSPTGGASAkplst------lslsKPNQQKPARNSPPKYDEH--QE-QFDMDL 137 Anopheles darlingi
Q7PN41         76 -------------VPmnl-lrtGVVSPNTKPmt-----------tlSVKQQKPARNSPPKYDEH--QE-QFDMDL 122 Anopheles gambiae s...
Q17JZ5         78 -------------LPhni--lrNGTTGVTSK----------------PKPQQQPQNSPPKFDEH--QE-QFDMDL 118 yellow fever mosquito
EDW44619       81 rgtprtpfrkcvpVPtel------------------------------------vkQTKSLKIE--DQEQFQLDL 117 Drosophila sechellia
EFA09088       75 -------------IPenl--mrGKTNGSAPI----------------RRFSPPTKNHSAKIEDSh-DEHQFQIDI 117 red flour beetle
12_pfamImport  71 -------------IPdcc--krGNDIKSNRE----------------NGLRRNPLKKTHENDDC--NE-QFQIDI 111
EGG24685       66 -------------PPemanmlnMINKSQSSPhphsk------pihsNKQPAAASTSAEAKNTTKqnEDDIFEMD- 120 Cavenderia fasciculata
NP_001040409   78 --------------------------ALLKNpssv--------pnvQPASTQKPRSNSISFDES--QE-TFSMDL 115 domestic silkworm
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