Conserved Protein Domain Family
COMPASS-Shg1
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pfam05205: COMPASS-Shg1 (this model, PSSM-Id:368336 is obsolete and has been replaced by 461586)
COMPASS (Complex proteins associated with Set1p) component shg1
The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.
Links
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Statistics
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PSSM-Id: 368336
Aligned: 92 rows
Threshold Bit Score: 49.1062
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDK43794              24 HLTTIYKKNGNFDKQRKE-LLENFkESETCKNLLLKLQIMIESKVKHDP-LILIKNKGKMAALIQGEIVNQrsgsHSLSn 101  Lodder...
GAA56247              11 EIIERLKSQGLFDRIRKH-CLEDIdLDGDYKFLQQRVNSFVSAFLQKQSkPIASE-KLELRERLRRELSNT----SMLT- 83   Clonor...
XP_018648151          13 HIVDQIKSQGLFDKIRKQ-CLEDVdVNSDYQVLQKKVNSFVSSFLQNQSwNPGVE-KLKLREQLRTRLLST----KMLS- 85   Schist...
XP_015793131           7 KIVNDLKARGVFDEFRKE-CLSAVdTRPAFENLRQKIDGKVKNYLESLTwDASLN-RNQLREKLRRSLTES----DNVI- 79   two-sp...
WGS:AAPP:GF18870-PA    7 SLIEEVKSQGVFDEFRFNcCLADVdTKPAYQNVRNRVETAVNDFLSKQHwTPDTN-KLQLRERLRKHLIDS----DVLN- 80   Drosop...
Q7PL13                 7 AMVHELKSQGLFDQFRKE-CLADVdTKPAYQNLRQRVEGTVNKFLGQQEwSDNIRYKNQLREQLRKNIIES----GFLD- 80   Anophe...
EEC16872              20 SIVSHLKSRGLFDQLRRD-CLGDVdTKPAYLNLKQRIEGYITKFLAMQTwTPDMN-KNHVRDIMRREINES----GMLS- 92   black-...
XP_014271740          19 rIVCKLKSQGIFDQFRKD-CLADVdTKPAYQNLQQRVNGTVATFLATQTwQQDLN-KTQLRESLRRHVQQ-----GFLE- 90   brown ...
XP_016841701          19 HIVGEVKSQGIFDQFRKE-CLADVdTKPAYQNLRTRVESSVNSFLNKQTwKTDLN-KNQLRETLRKHIHEA----PYLE- 91   jewel ...
XP_018671965          10 RIVERLKTNGIFDEMRRD-CLADIdTRPAFQNLKLRIENYVTSLLSAEVwTPTLN-KNQLRSKVRMSVMQS----GMLN- 82   vase t...

EDK43794             102 nnttdkgtgvslsekesytqdsngpsNTILGIVDRDIqekiiesEEFQFAIKEE 155  Lodderomyces elongisporus NRRL Y...
GAA56247              84 --------------------------TGVDRIVKNAVr------TKLPRDFQDQ 105  Clonorchis sinensis
XP_018648151          86 --------------------------CGVDRLVNQALs------AKMPKNFKNQ 107  Schistosoma mansoni
XP_015793131          80 --------------------------ATIQHLVDQVIa------QKATTYMLSR 101  two-spotted spider mite
WGS:AAPP:GF18870-PA   81 --------------------------KGVDQIVDQVVn------PKVATIFEPK 102  Drosophila ananassae
Q7PL13                81 --------------------------TGVERIVDQVVn------PKIATIFQPK 102  Anopheles gambiae str. PEST
EEC16872              93 --------------------------AGMDHLVDQIVn------PKIYHVFTPE 114  black-legged tick
XP_014271740          91 --------------------------VGVDRIVDQVVn------PKVFTVFMPK 112  brown marmorated stink bug
XP_016841701          92 --------------------------VGVERIVDQVVh------PKVYSVFMPQ 113  jewel wasp
XP_018671965          83 --------------------------TGVEYILHQVVd------SKMYSEFLPK 104  vase tunicate
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