Conserved Protein Domain Family
AF-4
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pfam05110: AF-4 (this model, PSSM-Id:368289 is obsolete and has been replaced by 461550)
AF-4 proto-oncoprotein
This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homolog Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.
Links
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Statistics
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PSSM-Id: 368289
Aligned: 33 rows
Threshold Bit Score: 945.278
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EOB06360         4 NEDRNLLRIRERERRNQEALQERDKFSENAPLFAEPYK---TNKEDELSSRIQNMLGNYE---EVKELISARCHQNLIGI 77   mallard
24_pfamImport    1 -EELEVLRRREWERRNQEAQQDRELFQESTPLFGEPYK---TNKGDELSRFVQRMLGNYE----------DENNSQYIQY 66  
21_pfamImport    2 NEERKLLRLRAWEQRNQGTSQAKD--QENMPLFGEPYK---TNKGDELSNLIQRMLGSYE---DVNH------------- 60  
18_pfamImport    2 NEERNLLRLRAWEQRNQETSQAKE--QENVPLFGEPYK---TNKGDELSNLIQRMLGSYE---DVNN------------- 60  
17_pfamImport    2 NEERNLLRLRAWEQRNQETSQAKE--QENVPLFGEPYKvqlTNKGDELSNLIQRMLGSYE---DVNN------------- 63  
13_pfamImport    2 SEERNRLRLRAWEQRNQETSQAPELASENVPLFGVPYK---TNKGDELSNRIQRMLGSYE---DVNN------------- 62  
2_pfamImport     2 REDRNVLRMKERERRNQEIQQGGEAFPANSPLFPEPYKv--SSKEDKLSSRIQSMLGNYD---EMKEPLGD-TLTKITSK 75  
20_pfamImport    2 REDRNVLRMKERERRNQEIQQAGEAFPANSPLFPEPYKv--TSKEDKLSNRIQSMLGNYD---EMKDLMGDRSLQKLVGI 76  
XP_018883148     3 REDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKv--TSKEDKLSSRIQSMLGNYD---EMKDFIGDRSIPKLVAI 77   western lowl...
6_pfamImport     2 REERNLLRLKERERRNQEIQQGEEAFPSDSPLFAEPYK---TSKEDKLSNRIQSMLGNYDemnEMNEMITDRSLPKLAGI 78  

EOB06360        78 PKS--IAP----LI-PQgkpdrp-ffpekTSHA-PSAFH--HAS-RHPHMGPPVVAPPPpshsVHYPK-AQSRAEPASGL 144  mallard
24_pfamImport   67 DGAmkDRP----SA-QHvrsgrp-shkdkT----DPSFQ--NLS-SYGTAQP-----------------GHPGHGSGQPL 116 
21_pfamImport   61 PNPaaMEPfripTYaSFsqsdqgqtsldgQAG---PPFH--TQAsGSQSQKAPGGSGVP----SQSSRtSGAASSPDHQG 131 
18_pfamImport   61 PNPtvTEPlripTYaAFsqldqgqksldsQAR---PPFH--NQAiSCQSQKAPTSNGCP----PQPSRtSGPASSPDRRG 131 
17_pfamImport   64 PNPtvTEPlripTYaAFsqldqgqksldsQAR---PPFH--NQAiSCQSQKAPTSNGCP----PQPSRtSGPASSPDRRG 134 
13_pfamImport   63 PYPfaIEPlpipSCvSFsqsdqgppnpdkPTK---PPFHnqVHYmSAQTQKAPSGNGCS----SQPLRtSAASSSPNHCG 135 
2_pfamImport    76 PSN--S-S----SS-SEeklgpn-lfggdQRGIsSSGSS--QSN-KWTPVGPAASGSa-----SQSQKrSA--L----GS 132 
20_pfamImport   77 PKP--TVP----ST-PDeksnqs-ffgesRHN----SSH--QGS-KWTPVGPAPGTS------LQSQKrSSSGLHSG--- 132 
XP_018883148    78 PKP--TVP----PS-ADeksnp--nffeqRHG----GSH--QSS-KWTPVGPAPSTS-------QSQKrSS-GLQSGHSS 133  western lowl...
6_pfamImport    79 PKS--AVP----PTaPDdktgqg-yfgdqRHG----SSH--QSS-KWTPVGPAPSTS------SQSQKrSSSSSQGGHSR 138 

EOB06360       145 -HAKSHSLSSGRSQgqEHGHGGQEGHtGSRHKRTE-RRAVGEG-RATEl-qASLLQLSPLLSPlstpv-tplspLHSSQH 219  mallard
24_pfamImport  117 kKFPFPHGSSVSHSkeEHSESHQQKMdTWSDM-------------------RDYSTLPPILPDlsppa-gplspLHSSES 176 
21_pfamImport  132 -NSSPFSNASLNPSqlSYAVPCHQRSeDRLRDh-----------ARLAq-----------eARshsppakplslQCSGDL 188 
18_pfamImport  132 -SSSTFSNVSLNHSqlSRMVHCHQKSeAHLREr-----------TGLAq-----------eVCsqspt-kslslQCPRDL 187 
17_pfamImport  135 -SSSTFSNVSLNHSqlSRMVHCHQKSeAHLREr-----------TGLAq-----------eVCsqspt-kslslQCPRDL 190 
13_pfamImport  136 -HSSSFNQLSLSAHq----------------qKRSeVLSDLREcASLSh-----------aISpqspdakplpvPHSSDN 187 
2_pfamImport   133 -QRGNGGSSSSSNSsqRHGGEVREKKsSKHSG-------GSEHsKSHTsspAK----GSLSSS------------SSSSH 188 
20_pfamImport  133 -QRSSNSSGSSGSSsqRHD---RETHsSSSS-SRKkNQHSTEHsKSHSsspSKPPAVGTLSSS------------HSRSQ 195 
XP_018883148   134 qRTSAGSSSGTNSSgqRHD---RESYnNSGSSSRKkGQHGSEHsKSRSsspGKPQAVSSLSSS------------HSRSH 198  western lowl...
6_pfamImport   139 -------SSGSNSSsqRHD---RDSYsS----SRKkGQHSSEHsKSRSispGKQ---SALNSS------------HSRAH 189 

EOB06360       220 VNSRsqnssksh-----------gptytqtKSPQDLVAGSQENESrdssavnLA----GTTQPSSQTFPPP-LPSKTsA- 282  mallard
24_pfamImport  177 GDSNqdmdnenehn------hslspeytgsSNRREPLHHLEPQKE-------VPqltgDAPPLVSQTFPLP-LSSKPnLa 242 
21_pfamImport  189 GTTGantkeacdhhpritpsecpgfgdasaLVPRDSTKDSCLPQAs------------KGHSLPSQTFPSL-LSKQPsVv 255 
18_pfamImport  188 ANTCtnkdtcdrlprls-ssecpgsgdvstPIPRDPTKDAPLPQTn------------KGNTLPSQTFPSL-LCKQPsVv 253 
17_pfamImport  191 ANTCtnkdtcdrlprls-ssecpgsgdvstPIPRDPTKDAPLPQTn------------KGNTLPSQTFPSL-LCKQPsVv 256 
13_pfamImport  188 DGEDtkem------------------dastFNLKQSPSDVSVLQAn------------KGAALPSQTFPSLlLSKQPsVv 237 
2_pfamImport   189 LRSSlaaeqhh------------gkeryrsKSPREREPNWDSPSR--------VhtsfPSGQHSSQAFPPS-LMSKPgS- 246 
20_pfamImport  196 gsdhhs------------------kdrqrsKSPHDPDANWDSPSR--------VhifsSSGQHSSQSFPPC-LMSKSsS- 247 
XP_018883148   199 gndhhs------------------kehqrsKSPRDPDANWDSPSR--------Vp--fSSGQHSTQSFPPS-LMSKSnS- 248  western lowl...
6_pfamImport   190 gndhhs------------------kerphaKSPRDPDANWDSPSRap---------sfSSGQHSSQAFPPS-LMSKSnS- 240 

EOB06360       283 MQQKPTAYVRPMDGQDQAPVESPELKPL-PEEYHTEPY-EKisdlkaNAKAKL-SKLKIPaEPIEQ-------------T 346  mallard
24_pfamImport  243 NSKKPMALVRPMDGPDQVTSESPDLKPS-PEDFHGQSY-ESlpdlknGSKPSL-PPLKVPaQSVEE-------------T 306 
21_pfamImport  256 MTQKPTAYVRPMDGQDQVVTDSPELKPS-P-----EPY-GPlpe--liTKPLMeTDRETLpPYLEFiklklr--ertftE 324 
18_pfamImport  254 MTQKPTAYVRPMDGQDQVVNESPELKPS-P-----QPY-VPlpe--liNKSHL-DKEKKLpPYLEVstsekqikkqnvnA 323 
17_pfamImport  257 MTQKPTAYVRPMDGQDQVVNESPELKPS-P-----QPY-VPlpe--liNKSHL-DKEKKLpPYLEIr------------- 313 
13_pfamImport  238 MTQKPTAYVRPMDGQDQVVSESPELKSS-P-----EPY-VPlse--liNKSDL-CRTKILsPFLEEk------------- 294 
2_pfamImport   247 MLQKPTAYVRPMDGQ-----ETAEPKSSqAESYSGQSHsSTmgemksNGKASL-SKLKIPsQPVEA-------------A 307 
20_pfamImport  248 MLQKPTAYVRPMDGQ-----ESMESKVP-SEHYSSQPNsTSmseiksSSKAHL-TKLKIPsQPLDA-------------T 307 
XP_018883148   249 MLQKPTAYVRPMDGQ-----ESMEPKLS-SEHYSSQSHgNSmtelkpSSKAHL-TKLKIPsQPLDA-------------S 308  western lowl...
6_pfamImport   241 MLQKPTAYVRPMDGP-----ESMEPKLS-SEHYSSQSHgSSmnelkpNSKAHL-TKLKIPsQPVDA-------------S 300 

EOB06360       347 F-PSDVQCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPA-KES------------------------------QHVG 394  mallard
24_pfamImport  307 L-PALSNEVQDILREMA-SWPPLLTAIHTPSTAEPSKFSFPS-NDC------------------------------KYIR 353 
21_pfamImport  325 MrPNEAQCVEAILREMTCSWPPILTALNTPNSDEPSKSPSQP-RGA------------------------------EHVS 373 
18_pfamImport  324 ErPNEAHCVEDILREMTCFWPPILTAVNSPNTGEPSKSPFQP-KGA------------------------------EHVS 372 
17_pfamImport  314 --PNEAHCVEDILREMTCFWPPILTAVNSPNTGEPSKSPFQP-KKScslifwpsphqrfsfcshfisyrlltgclhSYLL 390 
13_pfamImport  295 --SDEVLCVKDILREMSHSWPPLLITLHTPSTDEPSKSLLQV-KPAsnktllsfl-------------pplsgqlfHRLT 358 
2_pfamImport   308 VgSGDANCVDEILKEMTQSWPPPLTAIHTPCKTEPSKFPFPT-KDS--------------------------------HP 354 
20_pfamImport  308 M-SGDVSCVDEILKEMTQSWPPPLTAIHTPCKTDSSKFPFPTkKDT------------------------------QHSN 356 
XP_018883148   309 A-SGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPT-KES------------------------------QQSN 356  western lowl...
6_pfamImport   301 A-SGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPT-KDT------------------------------QQSS 348 

EOB06360       395 SVAQNqKQYDAPSKTLPSSQPRTSML---QDDLQLSDSEDSGDDQVVEKPPSSLAPPSALQSQPES-------------- 457  mallard
24_pfamImport  354 LKIQNiELFYTVFKTVSH-----VLLwasLSDLLLRENSVPQHPQLLSSSAPQLPSSSAPQLVPEDds------------ 416 
21_pfamImport  374 SHPGQrNRLNFSSQTVVQNQQLGfts-afRSDLSFLFSFSFHLAVLPEKCDTSAADASQQVHRRSSc------------- 439 
18_pfamImport  373 SHPGQt--------------------------------------VIPEKCDTSPADSSQHLQIPTQqssswyakacepkq 414 
17_pfamImport  391 TNADKa--------------------------------------VIPEKCDTSPADSSQHLQIPTQqss----------- 421 
13_pfamImport  359 TALGRr-----------------------LDQIFIDYYRMN---QKPVSPLLQIHPSSSSRAPQRNs------------- 399 
2_pfamImport   355 FPSGHi--ERGSSSKSSSSHQPKTML---EDDLKLSSSEDSDGEQDSAKNASRNTSQALPCTNSNN-------------- 415 
20_pfamImport  357 FAVGTqKRYNAPSKTSSSGHQSKSML---QDDLKLSSSEDSDGEQDSEKPVPRNTPGSNSDPTQHN-------------- 419 
XP_018883148   357 FGTGEqKRYN--PSKTSNGHQSKSML---KDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHN-------------- 417  western lowl...
6_pfamImport   349 FPSCEqKRYN-PSTKTTNGHPTKSSL---KEDLKLSSSEDSDGDQECDKTMPTNTPGS-SEPSQNN-------------- 409 

EOB06360       458 -------------------VASAHSSSPESGSTSDSDSS--SDSETESSSSDSEANdpDPP-RVSAP----E--PDPPT- 508  mallard
24_pfamImport  417 ------------------gVALAPSSGAESGSSSESGSSseSESDSESSESGKEEN--PPAaQNTSPakksQ--PKPNP- 473 
21_pfamImport  440 ------------------sFKVPHSRGLESTSSSDSESSsrSDSDSES-----AAE--EPP-KCPR---------SGPAa 484 
18_pfamImport  415 pmsennvslirtfvlfcssVKAAHSRGLESPSSSDSESSsrSDSDGES-----AIE--EPP-QCPC---------SSPAa 477 
17_pfamImport  422 ----------------scsVKAAHSRGLESPSSSDSESSsrSDSDGES-----AIE--EPP-QCPGSssmkAeqCSSPAa 477 
13_pfamImport  400 -------------------FEAAHSRGVE-FSSSDSESSsrSESESEG-----TIE--EPP-QLPVSisnvKtePDAPAv 451 
2_pfamImport   416 -------------------SEGAEQSRDDSSSHSGSESSsgSDSESESSTTDSETN--EHP-RPASP----E--PEQPM- 466 
20_pfamImport  420 -------------------GEGADNSRDDSSSPSGSESSsgSDSESESSSSDSEAN--EPS-RSASP----E--PEPPP- 470 
XP_018883148   418 -------------------SEGADNSRDDSSSHSGSESSsgSDSESESSSSDSEAN--EPS-QSASP----E--PEPPP- 468  western lowl...
6_pfamImport   410 -------------------SEGAENSRDDSSSHSGSESSsgSDSESESSSSDSEAN--EPS-RSASP----E--PEPPP- 460 

EOB06360       509 SN-KWQLDNWLTKVN----PPAVPAESPR-----ETAHTdg-hEEDKEPGQQIDSDSSHEHAE-PREPHHKS-SARAARA 575  mallard
24_pfamImport  474 QN-HSEIGPDLESVLntkpQLRTPPPE-------ETKPRtkrcHTSRTP---------------PAQVQPADaASEAKST 530 
21_pfamImport  485 KHvDWQLGNWIR----------SSQQNCHaeghcGPPASespgPPPSRCAA--------EAVEpSREAKPRQ-----EFT 541 
18_pfamImport  478 KHvDWQLGNWIP----------SSKQNSHaeghcDTRGSdsprPPQSVT----------EVVEpSWESKPQQ-----EFT 532 
17_pfamImport  478 KHvDWQLGNWIP----------SSKQNSHaeghcDTRGSdsprPPQSVT----------EVVEpSWESKPQQ-----EFT 532 
13_pfamImport  452 APvDWQLGNWIR---------------SSaksqsGAPASespaHSRPPPSQSSQLPVSAEVVDpNRESKPQLsTQQREFA 516 
2_pfamImport   467 SN-KWQLDNWFKKAKq--lSPASPVDS-------NVPTKc--kKEGRENSSGRGYGSQGGGSKdSTAPTPNR-DLRAAQK 533 
20_pfamImport  471 TN-KWQLDNWLNKVNphkvSPASSVDS-------NVPSSqgykKENRDQSTGSGYSAQ-SGSKdSSASTPGR-DSRATQK 540 
XP_018883148   469 TN-KWQLDNWLNKVNphkvSPASSVDS-------NIPSSqgykKEGREQGTGNSYTDT-SGPKeTSSATPGR-DSKTIQK 538  western lowl...
6_pfamImport   461 SN-KWQLDNWLNKGNphkvSPASSVES-------NIPSSqgykKDSQEQGAGTGYAEP-SGPKeSNTSTPGR-DSKAAQK 530 

EOB06360       576 SQ-------DAHlp------------tkRNCQK-SPA--CAEEPSQRQ--TVGIKRPSKP---PVHEGPKGGLKVESEpg 628  mallard
24_pfamImport  531 GP-------N------------------TGHKP-TP---KPTESGHRK--TVGNKQPGRSskaPRPEEAHSSLQVESVev 579 
21_pfamImport  542 ENagkpltyGARlecrhqepvratvpspTSGLS-SCShkHSRSPNPSSsaKAGSVHT------------AASVKCEKV-- 606 
18_pfamImport  533 KSagkphtySERhqdhykqpdnppappsSSGVT-SCShkHSCPTNTSTsaKAGSIQP------------PACVKCEKVg- 598 
17_pfamImport  533 KSagkphtySERhqdhykqpdnppappsSSGVT-SCShkHSCPTNTSTsaKAGSIQP------------PACVKCEKVg- 598 
13_pfamImport  517 DRlvrlqqhSKSsqdn--------ynhqSSQRFnSCSssRKPSFNKNSsiPEAAACPDRSa-------aPLVVKCEEVv- 580 
2_pfamImport   534 GA-------EGG----------------RGRQK-SPAq-SEGGPNPRR--SVGKKQPKKSekpPVVEEPKGGLRVESE-- 584 
20_pfamImport  541 GS-------ESS----------------RGRQK-SPAq-SDSSTTQRK--TVGKKQPKKAekaTLVEEPRGGLKVESEi- 592 
XP_018883148   539 GS-------ESG----------------RGRQK-SPAq--SDSTTQRR--TVGKKQPKKAe-kAAAEEPRGGLKIESEt- 588  western lowl...
6_pfamImport   531 GS-------ENS----------------RGRQK-SPAq--SESTTQRK--TIGKKQPKKTe-kSAVEAPRGGLKIESVt- 580 

EOB06360       629 PYEVRDQSSRDKPKVKTKgrpKSSDRKELKTSLQ-------EPPEGRKHKS-SHQASAKALLDPKPP------------- 687  mallard
24_pfamImport  580 TPRDKDSTFTDRPKVKTKsahEKSSVKKSRSKH---------THSNKKEGK-DSSAPPRTTLVVESS------------- 636 
21_pfamImport  607 --EDRDRCPTVRPKVKT----KMGPSRKNKERC---------DTKKAKERTsKHESHDKCEAGPESEvalvsyghcpscg 671 
18_pfamImport  599 AVLDKDPCFTVRPKVKT----KMGPSRKNKDRC---------ETKKDNKRTsKHASHDKLKAGSESEvalvlyghcpscg 665 
17_pfamImport  599 AVLDKDPCFTVRPKVKT----KMGPSRKNKDRC---------ETKKDNKRTsKHASHDKLKAGSESEvalvlyghcpscg 665 
13_pfamImport  581 ATQDKDTCFTDRPKVKT----KTGRSKKSKDNS---------DAKRDGKRTsKHVLLDKRKAGEEPEgavglcghcpscg 647 
2_pfamImport   585 ---PAPEIPPHRPKAATKgsrKPSIKKEPKSSPRptpaavtSAADKRKPKApTKTSQ-KSREFVDTD------------- 647 
20_pfamImport  593 PPEMPTSIPPNRHKAATKgsrKPNIKKEPKSSPR-------PAVEKRKYKSsSKPPQNKSREIIETD------------- 652 
XP_018883148   589 PVDLASSMPSSRHKAATKgsrKPNIKKESKSSPR-------PTAEKKKYKStSKSSQ-KSREIIETD------------- 647  western lowl...
6_pfamImport   581 TTEITTNLPPNRHKAATKgsrKPNIKKEPKSSPR-------PATERKKYKp-SKPSQ-KSREFVETD------------- 638 

EOB06360       688 ---------RDVVLGSTQEHLALSPIP-----QGQGTTPTrtsghrpaav---lredfhkeklPLSVREK--KLLSPVRD 748  mallard
24_pfamImport  637 ---------KPASPSPAAPRSTSPPPKststtETPTPTPTkssk---------------ksrpRSPSREK--KSQGVSRS 690 
21_pfamImport  672 vqypkscscAPHSPAQPGQLSPAPPIrfgcatpksdtv--------------pqkgtkvppkiTPGHLDK---TRRGLRD 734 
18_pfamImport  666 vqypnscpcPTHSPPQPDQLSPAPPIriscsksnsdvv--------------wqkgtkvppktTQKHLEK---TPQSSRN 728 
17_pfamImport  666 vqypnscpcPTHSPPQPDQLSPAPPIriscsksnsdvv--------------wqkgtkvppktTQKHLEK---TPQSSRN 728 
13_pfamImport  648 vqypipcscPPQSRARPDQLLPARLLKisgskdpesvc---------------krgtktplktTRKSSDKtgQTAKSSRD 712 
2_pfamImport   648 ---------SAASDSEGNDSIPSSS---------QTPKYTesirt--------------pvcvFSPMEEK--ELLSPLSD 693 
20_pfamImport  653 ---------TTSSDSEENENNSEGrtsnnksgle-------------------eeesflrqrmFSPMEEK--ELLSPLSD 702 
XP_018883148   648 ---------TSSSDSDESESLPPSS---------QTPKYPesnrtpvkpssveeedsffrqrmFSPMEEK--ELLSPLSE 707  western lowl...
6_pfamImport   639 ---------TSSSDSDENESLPPSS---------QTPKYSesnrtppakpsveeedsffrqrlFSPMEEK--EPLSPLSE 698 

EOB06360       749 V--------QVPRSLMVKIDLPLLSRVPQlp--gKGGHQK-RAEAK-EFPGARGQDVERKATDTPDKSFKKRK-----RE 811  mallard
24_pfamImport  691 Hp-------DPPQTLLVKIELSQLSRVPQlpkptKTSKTS-KTSKSsKSVSSKSKTSLEKELGSTGKPSKKRP-----AE 757 
21_pfamImport  735 Sr-------RCPRSLLVRIDLSLLSKVPQvsrnhRESLCKrKKASVvQPREGRSREASAAPK----LGKSSKKsh--hVK 801 
18_pfamImport  729 Sh-------RFPRSLLVKIDLSLLSKVPQisrnhRESLSKtKRSSAvKQHDGKSSEASTAQK----LGKSSEKsn--nEE 795 
17_pfamImport  729 Sh-------RFPRSLLVKIDLSLLSKVPQisrnhRESLSKtKRSSAvKQHDGKSSEASTAQK----LGKSSEKsn--nVK 795 
13_pfamImport  713 Sh-------RPSRSLLVKIDLRLLSRVPPtpsnhLETPSIaKRSVRvIEQDGGARDASASHK----LAKTSTKsssqnVE 781 
2_pfamImport   694 PeeryparqPQQQVLLVKIDLNLLSRIPGrp--yKDPVEI-KVERDdSLDRDGKDCSKPISEKSSSKAKRKHK-----ND 765 
20_pfamImport  703 Pddry----pvvQSLIVKIDLSLLSRIPGrp--yKEAQQP-KVEKKsLQEKHTRESLKQASDKSSNKGKRKHK-----NE 770 
XP_018883148   708 Pddr--------ypLIVKIDLNLLTRIPGkp--yKETEPP-KGEKKnVPEKHTREAQKQASEKVSNKGKRKHK-----NE 771  western lowl...
6_pfamImport   699 Peer--------ypLIVKIDLSLLSRIPGrp--yKEVEQP-KVE-KsAPEKHTKESQKQ-TDKSSTKGKRKHK-----GS 760 

EOB06360       812 ME-KEID-RKKMKSDKETksLQ-----SS---TNKDSTKQk----------APKASFETQKKDLLLPPPLPPMSPAHSAp 871  mallard
24_pfamImport  758 KN-DESVpKKKPKLEYHHhrLRsapvkPS---EKKTNKST--------------SKEKEKKSSKTTRPPLPPLPHGSSQe 819 
21_pfamImport  802 LD-IKGIpKKKPRLENHT-----------------SSSHAcg--------kLNGKKGLQRQTRFSGIPAQEFLQAQDQRf 855 
18_pfamImport  796 ATaGKQEyLIKSRLCKTGvgPHsgnilFLsscLFYDSDHVslfprpcrtirSSAEDREIKKAKKTPVPQQQHPTAKEASk 875 
17_pfamImport  796 VD-NKVVpRKKPRLENKNt----------------SSSHAsvkl---etirSSAEDREIKKAKKTPVPQQQHPTAKEASk 855 
13_pfamImport  782 VD-NASLpRKKQRLENKNtsSTnaplkPErscHPKDASDR-------------------KKAKKAPVPLLQPLTHKSPAk 841 
2_pfamImport   766 EE-SSKPeSKRCKLEEKS---------LS---HHKNSSKE-------------SKRSLEKKEEPVPSPSLSGLQRPPKVe 819 
20_pfamImport  771 DE-SGSSeNKKSKLEGRG---------SS---SHKTSTNK-----------ESTKHVAEKEKEPLPSPSVPLPQKESKTe 826 
XP_018883148   772 DD-NRASeSKKPKTEDKN---------SA---GHKPSSNR-----------ESSKQSAAKEKDLLPSPAGPVPSKDPKTe 827  western lowl...
6_pfamImport   761 QS-HRGC--RLYHIHLRRqyIYlskcrSN---DHTTNRKYf----------ITRTQTCQAPTDMLSSDS----KHESMSa 820 

EOB06360       872 ksvkmaqKRPRSEN---GQLPAteNNTARDSSSHKD-PLSAKHKKVERKHSEQVK-------------GNKGSAGD---V 931  mallard
24_pfamImport  820 qtkssghKRGGGEQedsGHVS---GSKHKKKSSSRE-EPDKNQKKKQNNNTASFL-------------NNKKVSKS---- 878 
21_pfamImport  856 keakgkrREAHGGPpssRQGDL------------------TRAQDSMLDSMEPPGskpfdmeplllpqELAKSSA----- 912 
18_pfamImport  876 ------dKRASAGFpktNKESC-----------KHKaKDSRKHKRSSGKRTEPLPp------------------------ 914 
17_pfamImport  856 ------dKRASAGFpktNKESC-----------KHKaKDSRKHKRSSGKRTEPLPp------------SDKKTTK----- 901 
13_pfamImport  842 gp--kmhKRSSGETpqtSKEAV------------KSkDLDTKHKKSRGKHTEPPH-------------CVKKSPK----R 890 
2_pfamImport   820 hp---srKRTVSQSstsLSSGT--GSGKEGNHSTKS-NSTSKHRKGDDKGRSTR--------------DGKEKSSKscdN 879 
20_pfamImport  827 hq---srKRTVSQSsnsKLGAS---SNKESGGSSSK-GNSSKHKKTEEKAAGSAK-------------EGKVKVPSsaaN 886 
XP_018883148   828 hg---srKRTISQSsslKSSSN---SNKETSGSSKNsSSTSKQKKTEGKTSSSSK-------------EVKEKAPSsssN 888  western lowl...
6_pfamImport   821 nfyclllSRTVSQSsslKSGSS--GSIKE---SSSKsSSSAKQRKTEGKSTSSAK-------------DPKEKSANstaA 882 

EOB06360       932 TNPFPVPSL-PNGTSKPRRPQVKFE-KQHSMEYHIEEAKRLKHKADAMTDKTGKAFQYLDAALSFIEYGIAMESDASAPK 1009 mallard
24_pfamImport  879 ADTTSEPST-SCAAPAPHRPLLKFEdRLYSVDHHMKEAKRLKHKADVTLDKTGKALRYLDAVLSFVESGIAMESDPQTPK 957 
21_pfamImport  913 ---ALPWSSsPTRKAWSRRPLLRWEdRQFPVNHYIKEAKKLKHKADAESDKLCKAFSYVDAAMYFVESGIAMERDHQTSV 989 
18_pfamImport  915 --------SePSGKALTQRPLLRPEdRQYPVKHYIKEAKKLKHKADAESDKLCKAFSYVDAAMYFVESGIAMEKDPQISM 986 
17_pfamImport  902 ----SSISAePSGKALTQRPLLRPEdRQYPVKHYIKEAKKLKHKADAESDKLCKAFSYVDAAMYFVESGIAMEKDPQISM 977 
13_pfamImport  891 NVCIPSSSSqPTGKALSSRPLFRSDqRQYPVKHYIKEAKKLKHKADAESDKLSKAFNYLDAAMYFVESGIAMEKDPHISV 970 
2_pfamImport   880 QLAVPPLST---DGSKSQRSKLMFEdRVHSADHYLQEAKKLKHNADALLDRFEKAVYYLDAVVSFIECGNALEKSAQEAK 956 
20_pfamImport  887 C---PPPSA-PSADMKLRRQKLTFDdRVYSADHYLQEAKKLKHNADALSDRFDKAVYYLDAVVSFIECGNALERSAQESK 962 
XP_018883148   889 C----PPSApTLDSSKPRRTKLVFDdRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESK 964  western lowl...
6_pfamImport   883 VAFIPPIDN------KSQRAKLVFEdRIHSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKSVQESK 956 

EOB06360      1010 SAYSIFADTIDLIKFIMTLKPFTDASASSHEKIFAVLCMRCQSLLHMAMFRYKKDTAIKYSRILNDHFKSSSRVTQAPSP 1089 mallard
24_pfamImport  958 SAYTMFSETLDLIRFTLKLKNFCDPSAPASDRDFLVLCMRCQALLQMAMFRCKRESALKYSRTLTEHFKN-VKNTPAPSP 1036
21_pfamImport  990 SSYTMLAETVELLKFVLKLKNSVDASAPPSEKDFVALCLKCQSLLHMAMFRHKQKAAVKYSKTLTDHFSNSAQRTQSP-- 1067
18_pfamImport  987 SSYTMFAETVELLKFVLKLKNSVDASAPSSEKDFIVLCLKCQSLLHMAMFRHKQRTAIKYSKTLTDHFSNAPQRTQSP-- 1064
17_pfamImport  978 SSYTMFAETVELLKFVLKLKNSVDASAPSSEKDFIVLCLKCQSLLHMAMFRHKQRTAIKYSKTLTDHFSNAPQRTQSP-- 1055
13_pfamImport  971 SSYTMFAETVELLKFVLKLKNSVDASASPSEKDFLSLCLKCQSLLQMAMFRHKQKSALKYSKTLTDHFSVSIKNSTTPDP 1050
2_pfamImport   957 SPFPMYAETVELIKYTMKLKSYMAPDATSADKRLAVLCLRCQSLLYLRLFKLRKDSALKYSKTLTEHLKNSLSNTQAPSP 1036
20_pfamImport  963 SPFPMYSETVELIKYTMKLKNYMAPDATAADKRLAVLCLRCQSLLYLRLFKLKKESALKYSKTLTEHLKNSYNNSQAQSP 1042
XP_018883148   965 SPFPMYSETVDLIKYTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSP 1044 western lowl...
6_pfamImport   957 SPFPMYSETVELIKYTMKLKSSAAPDATAADKRLGVLCLRCQSLLYLRLFKLKKESALKYSKTLTEHEEQCSCNSQAPSP 1036

EOB06360      1090 C-VAr---STGMPSPLSPMPSPAGSVSSqpgsnasncggnsiSSSVTIPYNIPSITSSYVNITSYILYAYDIWEQADALA 1165 mallard
24_pfamImport 1037 C-ISk---ITGTPSPMSPMPSPASSVSSglgsn-----pissSITVAIPQVIQQVASSYVNITALFLSAHDTWEQAEEIA 1107
21_pfamImport 1068 --LVstpkVSGTPSPMPSLPSPAPSSAGacssh----sgdpvSSFVSVPQAIEQVAFSYVNITSLFLRAYEIWEKAEELA 1141
18_pfamImport 1065 --LVmtpnIRGTPSPMPSLPSPAPTSSGsssnh----svdaiNAFVSVPQVIEQVAFSYVNITSLFLRAHEIWEKAEELA 1138
17_pfamImport 1056 --LVmtpnIRGTPSPMPSLPSPAPTSSGsssnh----svdaiNAFVSVPQVIEQVAFSYVNITSLFLRAHEIWEKAEELA 1129
13_pfamImport 1051 --SVvpfkVTVTPSYTPYMPSPATTSsssshsg---lgvdpvGSTVLIPHAIGQVAFNYVNITVLFVSAHDIWEQAEELA 1125
2_pfamImport  1037 G-MGn--kAAGMPSPVSPKLSPGTAGGYssvss-----sssaSSSVTIPQRIHQMAASYVQVTSNFLYATEVWDQAEQLS 1108
20_pfamImport 1043 GrLFs--kPTGMPSPVSPKLSPGNTGSYssaan----npsgsSSSVTIPQRIHQMAASYVQVTSNFLYGTEVWDQAEQLA 1116
XP_018883148  1045 G-LGs--kAVGMPSPVSPKLSPGNSGNYssgas----sasasGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLS 1117 western lowl...
6_pfamImport  1037 G-MGs--kSVSMPSPVSPKLSPGNSNNYsssvs----sssgsTSSVTIPQRIHQMAASYVQVTSNFLYATEIWDQAEQLC 1109

EOB06360      1166 RKNKEFFAELSAAVCPLALN-SSMTELVHYSRQGLQWLRLET 1206 mallard
24_pfamImport 1108 RRGSGLLKDLDAVIGQLSLT-SGMTPLVRYTRQGLHWLKLDA 1148
21_pfamImport 1142 RAGSGLLTELDTALGPLNLM-SSMAFMVRYTRQGVHWLRLDC 1182
18_pfamImport 1139 RKGSGLLTELDTVLGPLNLM-SSMTFMVRYTRQGVDWLRLDC 1179
17_pfamImport 1130 RKGSGLLTELDTVLGPLNLM-SSMTFMVRYTRQGVDWLRLDC 1170
13_pfamImport 1126 LTGSGMLTELDAVMGPLSLA-SSMSSMVAYARQAVHWLRLDS 1166
2_pfamImport  1109 KEQKDFFSELDKVMGPLIFNtSSMTELVRYTRQGLHWLRLDA 1150
20_pfamImport 1117 KEQKDFFTELDKVMNPLMFNtSTMTDLVRYTRQGLHWLRLDA 1158
XP_018883148  1118 KEQKEFFAELDKVMGPLIFNaSIMTDLVRYTRQGLHWLRQDA 1159 western lowland gorilla
6_pfamImport  1110 KEQNDFFTELDKVMGPLIFNsSTMTELVRYTRQGLHWLRLDA 1151
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