Conserved Protein Domain Family
TACC

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pfam05010: TACC (this model, PSSM-Id:368238 is obsolete and has been replaced by 461517)
Transforming acidic coiled-coil-containing protein (TACC)
This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumor suppressor (AZU-1). The functional homolog (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles.
Statistics
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PSSM-Id: 368238
Aligned: 27 rows
Threshold Bit Score: 177.921
Created: 5-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGF82130      489 FSQRNLDEQRQRlqknFENEFEVaqle----------iqdLTLSSQNLERENQ--KMKDTLKQWEQAVKLMITEKdKDKQ 556  Batrachochytr...
EFN83265      794 EKQKKHEVDLEK----QKATfqek-------------inkLQAQVAQEVKMKT--QMSVVVEEYEKSISRLLTEReRDRT 854  Jerdon's jump...
Q95TU9       1089 HNYNDMDELEKK----IKNEVTRsediekklkegelreeaLIKRITEKDKTNA--KLNGVIEAYEKAIAELISEKeQQAQ 1162 fruit fly
7_pfamImport    1 VSQKNLDMMIKA----MQMENLE-----------------LKSKYEELHLKYL--EMRKIMGGFLGTVPQETEEAqKQK- 56  
1_pfamImport    1 YSQKDLDTAVKA----AQEENQE-----------------LRSRCEELQRKNV--ELGVIMDRFEEVTYQVMGSLcGTES 57  
5_pfamImport    1 YSQKDLDAAVK-----ATQENRE-----------------LRGRCDELHRKHLghQLG-VIMDGEEVTSQVMEKFqTQKE 57  
XP_012915487  578 YSQKDLDAVVET----TREENVL-----------------LRSQCETLRARNL--EMGKIMDGFEGIVYQAMEEAqKQKE 634  domestic ferret
XP_003128852  541 YSQRDLDAAVEA----TQKENAE-----------------LRSRCTELQEKVL--EMGKIMDRFEETVYQAMEEAqKQKE 597  pig
AAI47884      611 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLL--EMGKIMDSFEGTVYQVMEESqKQKE 667  cattle
XP_005208350  611 YSQKDLDSAVEA----TQKENEV-----------------LRGKCAALQERLL--EMGKIMDSFEGtVYQVMEESqKQKE 667  cattle
EGF82130      557 QKQAEIDRLKEQLDLAYAERNESKKE-LDQMSLKYKQLRVDISDLKELDERQREQISELEQTVATGNQRFDSLRAHAETK 635  Batrachochytr...
EFN83265      855 NFEQEKAKLQEELQAANHHLTNTEAA-FNDVHQKYERLKGVVSVYKNNEAVLKESIQENVDTIKTLETRYDQLKDHAMAQ 933  Jerdon's jump...
Q95TU9       1163 LHERQLQEVQADRDANYHHLTSLETT-FSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQ 1241 fruit fly
7_pfamImport   57 ----EIAKGLKGKGQLITDMNSINTS-FSGLFKGYEKQKEVIKGYSKNIESLNYECK---------------WKAHTDEK 116 
1_pfamImport   58 LGMKETGKVIEDQNQLLVTVFHVQKS-IAGLASAHR---------RKSGPGLKKCAEDYLVRVTQAGQRYQALKAHAEEK 127 
5_pfamImport   58 LAKADIKVL-NEKDQLTADLNSHERSlFSD-SKRFENRKEVMEG-RRMEESLRKCAENYLARVTKAGKRYQALE-HAEEK 133 
XP_012915487  635 LAKAEIQKILKEKEQLTADLSSMEKS-FSDLFKRFEKQKEVIEGYRKNEELLKKCVEGYIARIEKEGQRYQALKAHAEEK 713  domestic ferret
XP_003128852  598 LARVEVQKALQEQEHVSGDLRSVEKS-FSELFRRFEKQKEVIEGYRTNEASLKKCVEEYMERLEKEGQRYQALKAHAEEK 676  pig
AAI47884      668 LTKAEMQKVLKEKAQLTADLHSMEKS-FSDLFKRFEKQKEVIEGYRTNEESLKKCVEDYIERVEKEAQKYQALKAQAEEK 746  cattle
XP_005208350  668 LTKAEMQKvLKEKAQLTADLHSMEKS-FSDLFKRFEKQKE-------NEESLKKCVEdyiERVEkEAQKYQALKAQAEEK 739  cattle
EGF82130      636 LDEANVEIARVRASYEKEAAAMRAKLSRVEIQMQTLDCNLKTKVQENQELTKICDDLV 693  Batrachochytrium dendrobatidis JAM81
EFN83265      934 LEKANLELDGIRKQNEAETVKLHAMIRKAELKSNSLAELVEQKTKENKELAKILDEVI 991  Jerdon's jumping ant
Q95TU9       1242 LEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELI 1299 fruit fly
7_pfamImport  117 FNVADEEIAQVH-------RKVQVILTKGQMRNHSLE-IIRQKTKDYNKLIITCYDLI 166 
1_pfamImport  128 LQLANEEIAQVRSKAQAEALALQASLRKEQMRVQSLERTVEEKTKENEELTRICDDLI 185 
5_pfamImport  134 LQLANEEIAQVRSKAQAEALALQASLRKEQMWVQSLERTVEEKTKENEELTRICDHLI 191 
XP_012915487  714 LQLASEEIAQVRSKAQAESLAFQASLRKEQMRIHSLEKTVEQKTKENEELTRICDDLI 771  domestic ferret
XP_003128852  677 LQLASEEMAQVRSRAQAEVLALQAVLKKEQMRVQSLEKAMEQKTKENDELTRICDDLI 734  pig
AAI47884      747 LRQASEEIAQVRSKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 804  cattle
XP_005208350  740 LRQASEEIAQvrsKAQTDALALQAVLRKEQMRVHSLEKVVEQKTKENDELTRICDDLI 797  cattle
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