Conserved Protein Domain Family
HAP1_N

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pfam04849: HAP1_N (this model, PSSM-Id:368153 is obsolete and has been replaced by 461455)
HAP1 N-terminal conserved region
This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologs. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34.
Statistics
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PSSM-Id: 368153
Aligned: 28 rows
Threshold Bit Score: 324.238
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003642869         123 QLPRYTLRADTVF---GYDHEDW-LHAPP---ASQPTAPLTPQQIEETLWy------------------fLLCAErAVRI 177  chicken
XP_008118730          32 QLPQYKLRVDSLY---LSDNDSW-IPSPSc--PSHVPEIVSPVLAEETFRymtllelppsclagshkhaqVLSTErRDQV 105  green ...
ETE59403              23 QLPQYKLHVDSLY---LPVNDDW-IQSRSs--HSHGPEISSPVLAEEALHy------------------mIAGTGrGEHV 78   king c...
EEN54474              22 EIPRYKLRADTVF---GYENKDW-LESPAl--PPDTPVDLSPEQAEETLKy------------------fALCSDrVAQM 77   Florid...
12_pfamImport          3 HIPRYKLRADTLTtfsGYENQNWfIPSPAl--QLDSDVDLSPEQAEETFKy------------------fALCSHrVSQM 62  
EFX86135              23 KIPLYTLRGDSAAaltGYQSQSWyIPPPSqriPAPTEDLLTPEQTKETLNy------------------fLLCGErVSQM 84   common...
WGS:AAQB:GK15273-PA   91 QIPKYKVRSDFLTdfsGYANEDWfVPAPAlpiPPE-GLGLTKDQTRECLNy------------------fLLCGNrVSQM 151  Drosop...
EFA09509             117 QIPKYKLRADTLTkfgGYENQDWfIPSPAl-qIDEADLKLSPDQIRETLNy------------------fLLCSNrVSQM 177  red fl...
XP_002936582          32 QLPQYKLQVDSLY---MYDNQDL-IQSPAh--QSNGPRNLSPVLAEEPFRy------------------tILGSErVEQL 87   tropic...
XP_012430446          32 QLPDYKLRVDSLY---LHENADW-IQPMAc--HGWLPETASSAREEDSFCymtlielpsssldgshkfaqVLGTEnTEQ- 104  zebra ...
XP_003642869         178 tKTYHDIDAVTNLLDEKERDLELAARIGQSLLKQNRSLTERNELLEEQLELAKEEIAQLRHEVSMRDDLLHFYTTNTEEN 257  chicken
XP_008118730         106 tNNCNDSEVVTHLLAERDRDLELAARIGQALLKRNHILTEQNEALEEQLAQAFDKVHQLQHELTKKDELLRVVSIASEES 185  green ...
ETE59403              79 pKNCNDIEVITQLLAEKDRDLELAARIGQALLRRNHSLTEQNDVLEDQLGQAFDKIHQLQHELTKKDELLRVVSTASEES 158  king c...
EEN54474              78 tKTYNDIEAVTRLLEEKERDLELAAKIGQSLLERNRLLSQKNDYLEEQLQIVSERNNQLQHELQLKEDLLQIYTQEESLS 157  Florid...
12_pfamImport         63 tKTYNDIEAVTRLLEEKEKDLELAARIGQSLLARNRDFEQKNDQMEQELTLLSDQVTQYKHELAMKTELLQIYAHDLDYS 142 
EFX86135              85 tKTYNDVEAVTRLLEEKEKDLELAARIGQGLLTRNKALEERLIAVEGELHSAHDTVTQLRHDLLLKGELLQIYSNDFDDS 164  common...
WGS:AAQB:GK15273-PA  152 tRAYDDIEAVTRLLEEKEKDLELTVQIGQDLLKQNNALELRVSHLEAELKESNDDRSQLVHELHKKNELISVLTDDADDG 231  Drosop...
EFA09509             178 tKTYDDIEAVTRLLEEKEKDLELTARIGKELLQANSKLENTIASLETDLKSALEKITQLSHEVQKKTELIQILTNDMDES 257  red fl...
XP_002936582          88 sRSY-DSDMLSHLLTERDRDLELAARIGQALLKRNHILTEQNESLEEQLAQALDHVNQLQHELSKKEDLLRVVSIASEES 166  tropic...
XP_012430446         105 -KDYGEADMVKRLLAEKDRDLELAARIGQALLKRNHLLMEQNEALEEQLGQTLDRVNQLQHELSKKDDLLRIVSIASXES 183  zebra ...
XP_003642869         258 EPTSAPITP-LRRNESSlSLQQYFQYDALQQKLRCLEEENQKLRLEATTIvtetSRYEDQEQQLMIDCVEQFSAASQQVV 336  chicken
XP_008118730         186 ETDSSCSTP-LRFNESFnLSQGLVQLDILQDKLRDLEEENLSLRTKACHLktetMTYEEKEQQLVSDCVKEIRETHAQIA 264  green ...
ETE59403             159 ETDSSCSTP-LRFNESFnLSQGFLQLDILQDKLRELEEENLLLRTKACHLktetMTYEDKEHQLVTDCVKEIKETNAQIA 237  king c...
EEN54474             158 ETDSSCTSPaTRHDRTLlLPSGLVNIDALHKKIQTLEEENLHIRSEAAKLktetVDYEEQEAKLVSDCVKELKEANTQIK 237  Florid...
12_pfamImport        143 ESDSNPTSPtCRDRISL-----HVSWDVLQKKIRKLEGENEQLKSEANILddetTTFEEKEQQLVKDVVRQLSEANMNVD 217 
EFX86135             165 SPEGVRA----------------FTTDLLQRKVKGLEDDNRKLRAEASQLanesSETELREEQLLHQVVAQLAEANNHIK 228  common...
WGS:AAQB:GK15273-PA  232 TDADTPTMS------------KSVTLDLLQKKVNSLLDENKTLKHEATQLahqtDEVEEHERKLMADIGAQLNDANSQYD 299  Drosop...
EFA09509             258 IFENGTSGR--------------INLELMQKRMAGLEEENKALKSEYNRLardtETVEAKEQMLLKDLTGQLTCANTSMG 323  red fl...
XP_002936582         167 ETDSSCSTP-LRSNDSFtISHSLLQLENLHGKLRELEEENFSLRTKASHLkteqITYEEKEQQLVIDCVNEIRESNVQIN 245  tropic...
XP_012430446         184 ETDSSCSTP-LRFNESFtVSHDPLQLDVLQDKLRELEEENLALRSKACHLksetITYEEKEQQLVNDCVKELRQTNAQIS 262  zebra ...
XP_003642869         337 CLSEELARKAEDTARQQEEISQLLAQVVELQQKCRTYGTEVEELQQHLAAAKEVQqqlrTELQDLQDKYVEcggmlqeAQ 416  chicken
XP_008118730         265 QMSEELTRKNDELLNYQEEISSLLSQIVDLQHKIKEHVIEKEELKLHLQASKDAQrqltAELHDLQERNAEclgmlheSQ 344  green ...
ETE59403             238 RMSEELMRKDEELIHYQEEISSLLSQIVDLQHKIKEHVIEKEELKLHLQASKDAQkqltAELHEVQERNVEclgmlheSQ 317  king c...
EEN54474             238 QLTEELVRKNEDNARFQEESTSYLAQTIDLNKKLKKSALENEELQQHLRVAKETQqeltEELRDLEEKYQEvmgmlheAQ 317  Florid...
12_pfamImport        218 QLSEELSKKIDDNLRQQEEITMLLAQLVDFQQKNKKINVENEDLQQHLHAAKECQqeltTELADLKEKYREvvemlheNQ 297 
EFX86135             229 NLDEELANKYDEAGKHREEITSLLGQLVSQRHKIRELTLENEDLTMQLHVVRDCQtelvAELSEYKDKYAEilellheTQ 308  common...
WGS:AAQB:GK15273-PA  300 NLSLDLERQMEENRLQHEQIVNLTARLREAEMRLHQLTEDNEGHLSMLHITKETQnalaLELVEFKQRYEEvlallhsAQ 379  Drosop...
EFA09509             324 FLEDELDRQKEENRFQHEQILTLQSKLQDMEERLNKFMSENYELNGLLQITKDNQgslaIELSEFKARYYEvesllrdTQ 403  red fl...
XP_002936582         246 KLTDELASKSEDIIRYQEEISTVLSQVVDLQHKLREGAVEKEELRIHLQASKEAQrqltAELHDLQDRNAEiqgmlqeYQ 325  tropic...
XP_012430446         263 RITEELSEKSEEVIHYQEEISSLLSQIVDLQHKLKENVIEKEELKLHLQASKDAQrqltAELHEFQDRNAEclgmlheSQ 342  zebra ...
XP_003642869         417 EEVKSLRSR 425  chicken
XP_008118730         345 EEAKGLRSK 353  green anole
ETE59403             318 EEVKGLRSK 326  king cobra
EEN54474             318 AEAKTMRKK 326  Florida lancelet
12_pfamImport        298 EQLRD---- 302 
EFX86135             309 EQVKEQNKR 317  common water flea
WGS:AAQB:GK15273-PA  380 DQLKQQRKR 388  Drosophila willistoni
EFA09509             404 EQLRKLRKK 412  red flour beetle
XP_002936582         326 DELKMMRCK 334  tropical clawed frog
XP_012430446         343 EEVKLLRSR 351  zebra finch
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