pfam04825: Rad21_Rec8_N (this model, PSSM-Id:368143 is obsolete and has been replaced by 461446)
N-terminus of Rad21 / Rec8 like protein
This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.
Jiyao W et al.(2023). "The conserved domain database in 2023.",