Conserved Protein Domain Family
LMBR1
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pfam04791: LMBR1 (this model, PSSM-Id:368121 is obsolete and has been replaced by 461429)
LMBR1-like membrane protein
Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought. Vertebrate members of this family may play a role in limb development. A member of this family has been shown to be a lipocalin membrane receptor
Links
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Statistics
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PSSM-Id: 368121
Aligned: 82 rows
Threshold Bit Score: 135.075
Created: 6-May-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P34535        67 RQQIICMWLFMLLYLFAYWLISRLKRKTEREAlyagee--dyfvyrVSVWISSTATATSIGSLTLLPFSVIGVELLQ--L 142 Caenorhabditis ...
EXX64430      25 RQNIIAFLLFVSLYSISYSLLQRFRRKNRITDieeeeddpygidslIIIILCAGGLAMALAGFLLWPFTMIATALLHneI 104 Rhizophagus irr...
EEC43650       5 FLIVATVVAIVILLIIASYLLVHYQHPDDHNda------------yVPKLIVLLGFVLAGATVLMLPLDVANNEG----- 67  Phaeodactylum t...
EFN58402       4 FLIIITVVVAILVLLVSLYLVVHFQHPEDKNqa------------wLPKLVVLLGFSVAFWTILLFPLDVANQQAC---- 67  Chlorella varia...
BAJ85289       7 ALVIVAAVVSVLVLLVSVYLLVNYQHPDDANqa------------yFPKLVVVLGITVAVLSILMLPADVANRQAC---- 70  domesticated ba...
Q9SR93         7 ALVIVAIVVCVIVFISSIYLLVNYQHPDDANqa------------yFPKFVVVFGLSIAMISILMLPADVANRHAC---- 70  thale cress
EFJ32053       7 ILLIIVIVVTVLVFLFNTYLLVNYQHPDDHNqa------------yFPKAVVVFGLSVAQLSILMLPADVANRHAC---- 70  Selaginella moe...
ESS30088       4 IILVFFLLYFLITLLANLKLLFYFEHSSDSSLtap---------evVCKVTILAGLQLAWLLILAVPLDAYNQHSP---- 70  Toxoplasma gond...
CBZ50084       4 IILVFLLLYFFITLLANLKLLFYFEHSSDSSLtap---------evVCKVAILSGLQLAWLLILAVPLDAYNQHSP---- 70  Neospora caninu...
XP_009392724   7 ALLIVAVVVSALVLLVSVYLLVNYQHPDDHNqa------------yFPKLVVVLGISIAAISILMLPADVANRQAC---- 70  wild Malaysian ...

P34535       143 YDGNYYLQWLSYSL-IGALWNYVFVLSNVSLFVLLPFSYFFIESQGFSTSKign-----dmtQRI-YEAMAISFLFAFVL 215 Caenorhabditis ...
EXX64430     105 FSGNYYLTWLDVEL-LVTLWNYAFIGCNISLFALLPFAFFYSETDQLRTFF-----------AKA-RETLIIMGLVGMLM 171 Rhizophagus irr...
EEC43650      68 -YAGYDTGLCG-GLnMELMWDIVFWMIPIWVFVLIPFATFYYEADDGMLmagtayapnpvrqSRI--GQAICYQLFVFVI 143 Phaeodactylum t...
EFN58402      68 -ELDIPLSSCS-TMpMKELWYAMYIANMAITFIAVPFCIFYYEADSDWSv-----------fRRS--LSGALWAAGTVFV 132 Chlorella varia...
BAJ85289      71 -KRAVYSGACSLTLpMKTLWLVVYIIDAVLVFLVIPFAMFYYEGDQDKSv-----------gKRL--KSALIWVVASAVV 136 domesticated ba...
Q9SR93        71 -RHAIYNGACNLTLpMKDLWLAIYIVDAILVFFVIPFAMFFYEGDQDKTl-----------gKRI--KSALIWVVTTAVV 136 thale cress
EFJ32053      71 -QRALYNGACDLTLpMKDLWYAVYIIDAVLVFLVIPFTMFYYEGDQEKSv-----------aRRA--VGALMWVIVIAIV 136 Selaginella moe...
ESS30088      71 -FVDKAAGVATAGLdMRLYWGVVAWFTALYLLFAVPFATFYYEADFDSRv-----------sRRTpWKRALSKTVLAVCC 138 Toxoplasma gond...
CBZ50084      71 -FIDKAAGALTAGLdMRLYWGVVSWFITLYLLLAVPFATFYYEADFDPRv-----------tKRTpWKRALLKTLLAVFF 138 Neospora caninu...
XP_009392724  71 -RHAIYNGACSLTLpMKQLWLAVYIADAILVFFVIPFAMFYYEGDQDKGi-----------gKRL--KSALLWVVTSAIV 136 wild Malaysian ...

P34535       216 LCLAEVVLTIl--------------------------------------------------------------dYPVSFL 233 Caenorhabditis ...
EXX64430     172 YGFIYTLKMLf------------------------------------------------------------------GIS 185 Rhizophagus irr...
EEC43650     144 IGVIFAVTYIslsdskipvqeyvgpalgkvnqgftysaqr----natddllpfdsdglqpwgdsdttylsnvvdNGEQTL 219 Phaeodactylum t...
EFN58402     133 MAILIGIPYAfagnaqytvqgarsgllpisylsnaedsftnciglfsyydqdsgqpklnstlvslgyncdtlinQLSEVW 212 Chlorella varia...
BAJ85289     137 CGLVLGILYAligkvdftvrhlsssvqtfpgpnqf---------------gaftsgqpciapltrqcsantapaNSQTTW 201 domesticated ba...
Q9SR93       137 CALVLGILYGvigkvdfsvrhlasatstfptsw------------------qfsntqpcigntarqcsaftanpTSEKTW 198 thale cress
EFJ32053     137 VGLVLGILYGligkvdftvrhlssttigfttdysq---------------ltsrspclvptnspnacsaynagyGAEATW 201 Selaginella moe...
ESS30088     139 AGLVVFVVYIlcrsislkidddlcsqwqsqdvsqplk--------------dfceaaartaagpsssqsdakkeesfASL 204 Toxoplasma gond...
CBZ50084     139 AAVIVFVVYIlcrsislkldqdlcsqwqsqdvsqplsd--------fcaaiaqtaagpplssspqsdakasenvEPPKPL 210 Neospora caninu...
XP_009392724 137 CGLLLGILYGlvgkvdftvrhlsssaesfpssw------------------tgfsrsqpcisssrlcdayiapaTSEKTW 198 wild Malaysian ...

P34535       234 sITsVNLPLIYSCVSFIGAVLLLISTPYGFAKM-FSLARdflvteetadieeenseqsedvtepknsssdetihqvdrsd 312 Caenorhabditis ...
EXX64430     186 nVDeLEMLNLFTCIG--GALICLKATPRGYIEI-FSCISklpl------------------------------------- 225 Rhizophagus irr...
EEC43650     220 vLQvSLSTFYAGLMAWLGWFLFAIFGGIGLAALpLDLYLmfknrprhmdaaef--------------------------- 272 Phaeodactylum t...
EFN58402     213 tIRvSIIVYAMAIVATLGWVLFMVFGGIGLVALpIDWIRefiarpkat-------------------------------- 260 Chlorella varia...
BAJ85289     202 tMRaTFPEYVVALATIVGSVLFTIFGGVGIACLpLSLIFsfvrrpkav-------------------------------- 249 domesticated ba...
Q9SR93       199 tMRtTFPEYVVALATIVGSVLFTIFGGVGIACLpLGLITafirrpkav-------------------------------- 246 thale cress
EFJ32053     202 sMRtTFPQYLIALTTIVGSVLFTIFGGVGIACLpLSLIFaffkrptav-------------------------------- 249 Selaginella moe...
ESS30088     205 nMKvDLGVYLLAAMSFVGWFTFALFGGIGVAALpLDAFVnfrrrprai-------------------------------- 252 Toxoplasma gond...
CBZ50084     211 dMKvDLSVYLLAAMSFVGWFTFALFGGIGMAALpLDAFVgfryrprai-------------------------------- 258 Neospora caninu...
XP_009392724 199 tMRtSFPEYVVALATIVGSVLFTIFGGVGIACLpLGLIFsfirrpkav-------------------------------- 246 wild Malaysian ...

P34535       313 tphledvvnditenvdadgefRKDSDSGIESGSTEEMRLNTDDEEMGindsddksafgddgdlgnstptknkkkrrkhdy 392 Caenorhabditis ...
EXX64430     226 -----------------rpnyRRSLKEKLKRNKMDITVWQQRLENLE--------------------------------- 255 Rhizophagus irr...
EEC43650     273 --------aeaqlslrervneMVDIGELIKIE------------------------------------------------ 296 Phaeodactylum t...
EFN58402     261 ------------itrsqyidrARDLA---RRA------------------------------------------------ 277 Chlorella varia...
BAJ85289     250 ------------itrsqyikeATELG---KKA------------------------------------------------ 266 domesticated ba...
Q9SR93       247 ------------itrsqyikeATELG---KKA------------------------------------------------ 263 thale cress
EFJ32053     250 ------------itrsqyikeATILG---KRA------------------------------------------------ 266 Selaginella moe...
ESS30088     253 -------------slstfkeiRRQLG---EKA------------------------------------------------ 268 Toxoplasma gond...
CBZ50084     259 -------------slstfkevRRQLG---EKA------------------------------------------------ 274 Neospora caninu...
XP_009392724 247 ------------itrsqyikgATDLG---KKA------------------------------------------------ 263 wild Malaysian ...

P34535       393 aattpivrkwdkdvpkkpknpnfdyRNLKeyvkearrqrsslsesddywfgspprssfsanyyssrfsrwkhnsetglnp 472 Caenorhabditis ...
EXX64430     256 -------------------------RGLRsiysvnn-------------------------------------------- 266 Rhizophagus irr...
EEC43650     297 -------------------------REQKaqaglt--------------------------------------------- 306 Phaeodactylum t...
EFN58402     278 -------------------------KDILal------------------------------------------------- 283 Chlorella varia...
BAJ85289     267 -------------------------KELKka------------------------------------------------- 272 domesticated ba...
Q9SR93       264 -------------------------RELKka------------------------------------------------- 269 thale cress
EFJ32053     267 -------------------------RELKet------------------------------------------------- 272 Selaginella moe...
ESS30088     269 -------------------------KKLRfi------------------------------------------------- 274 Toxoplasma gond...
CBZ50084     275 -------------------------KKLRfi------------------------------------------------- 280 Neospora caninu...
XP_009392724 264 -------------------------RELKkt------------------------------------------------- 269 wild Malaysian ...

P34535       473 sssllvdpfasgdfheassseasstpLSPA---------------------------RRTKSEEAIWKPVLHTVKSSKLY 525 Caenorhabditis ...
EXX64430     267 --------------------tsrsaiLVPStesqysysseklyasgianniitnrsgHLSNSRNEIIAKINKLEEEEKRL 326 Rhizophagus irr...
EEC43650     307 ---------------------------------------------------safatfSLNSDT--------RKAARDEN- 326 Phaeodactylum t...
EFN58402     284 -------------------------------------------------------adALKREE--------RERGRSWRW 300 Chlorella varia...
BAJ85289     273 -------------------------------------------------------aeALHQEE--------RSGNKGRKW 289 domesticated ba...
Q9SR93       270 -------------------------------------------------------adGLHQEE--------RSGAKGRKW 286 thale cress
EFJ32053     273 -------------------------------------------------------tlALQREE--------RSSGKGRKW 289 Selaginella moe...
ESS30088     275 -------------------------------------------------------geALRDEEALQQTLSWKEVRRKRQF 299 Toxoplasma gond...
CBZ50084     281 -------------------------------------------------------geALCAEETVQQTLSWKEIRRKRQF 305 Neospora caninu...
XP_009392724 270 -------------------------------------------------------ieTLHQEE--------RSGSKGRKW 286 wild Malaysian ...

P34535       526 KRAIEKQ--------------------Gr---LvklFMSLRFPVAAAAL----LVLTTCSLIMVATNTL----KLLFgyr 574 Caenorhabditis ...
EXX64430     327 QKDLSHS-----------------------------------PLYRNMLflvlFIVSHFIWLLILGHILyalmKSLLvdd 371 Rhizophagus irr...
EEC43650     327 -QAVLGFkqavylleq---dvedfqnaTv---NykkYNVLIPYIA-LLLslcaFIVSIFWFIHVIVYVFp---------- 388 Phaeodactylum t...
EFN58402     301 RRNIKALnnqlivleedetqlelvypqSed-pDykwVLTVMGFWLKFFGgllgLAMSICWVLQIILYILi---------- 369 Chlorella varia...
BAJ85289     290 RKNVKAVekellllendmnaleemypqGek-aEatwAFTVLAYIGKLIFgivgLIVSIAWVAHIIIYLLv---------- 358 domesticated ba...
Q9SR93       287 RKNVKAVekellqleedvnlleemypqGeq-aEtawAFTVLGYLAKFILgivgLIVSIAWVAHIIIYLLv---------- 355 thale cress
EFJ32053     290 RKEMKKVqqellyleedvqrleeaypqGek-aDttwALTVLGYLSKLLLglvgLVVSGAWVAHIIVYMLi---------- 358 Selaginella moe...
ESS30088     300 RTDMNRYrkavfdlehehrqlaismreRgenpFfsyF--------KLLLgvvaLFMSLLWTAHTVLNCVm--pQILDvsa 369 Toxoplasma gond...
CBZ50084     306 RTDVNRYkkavfdldqehrqlaicmreRgenpFfsyL--------KLFLgivaFAMSVIWTAHTILNCVl--pQILDvss 375 Neospora caninu...
XP_009392724 287 RKNLKEAekelflleddmkaleemypqGeq-aEtvwALTVLGYLAKFVLgvvgLIVSVAWVAHIVIYLLi---------- 355 wild Malaysian ...

P34535       575 sLP-----VYAQYIeVHTRHSFGLFGACIETLLIIYVMITSFVGLYSL----PVLRSLRPv-RKDTPMPTIIINSSIVLV 644 Caenorhabditis ...
EXX64430     372 gKEl---kNLEALIgKQTVSLFG-FGTLNEITLIFCFTSATIIGVYSI----SPFKRIRPr-LGKMTVQQIIANVTVLLV 442 Rhizophagus irr...
EEC43650     389 -SPplapfLNNYFEwF--DKWFPLFGVLSVALFVSYLLLAALKGCFKFgi-rFLFFHIHPmkVGKTYMSSFMFNIALVLL 464 Phaeodactylum t...
EFN58402     370 -DPpvtplLNDMFIkA--NDAFPLFGTLLFGLFAFYLQLCVTKGNFKFgl-nLLIFRVHPmrRGATIMSSFLFNVALILL 445 Chlorella varia...
BAJ85289     359 -DPplssfLNEIFIkL--DSVWGLLGTAAFAFFCFYLLIAVIAGEMMLgl-kLVFITIHPmkWGGTLMNSFLFNVGLILL 434 domesticated ba...
Q9SR93       356 -DPplspfLNEVFIkL--DDVWGLLGTAAFAFFCFYLLLAVIAGAMMLgl-kLVFITIHPmkWGATLMNSFLFNVGLILL 431 thale cress
EFJ32053     359 -KPpfssfLNQVFIkL--DDVWGLLGTVAFAFFCLYLILAVISGEMHLgl-nFGLIAIHPmkYGGTLMNSFLFNVGLILL 434 Selaginella moe...
ESS30088     370 sSHpafgfLD-AFLkLLAEHSAALLALLIYAAFVCYLLICVVKGCFKFggsvFCIIGIHPmrKDETHLNSFLFNVVLVLL 448 Toxoplasma gond...
CBZ50084     376 tSNpvfgfLD-AFLrLLADHSAALLALLIYAAFVCYLLVCVVKGCFKFgasvFCFIGIHPmrKDETHLNSFLFNVVLVLL 454 Neospora caninu...
XP_009392724 356 -NPplspfLNEVFIkL--DSVWGLLGTAAFAIFCFYLLLAVIAGEMMLgl-kLVFFTIHPmkWGGTLMNSFLFNVGLILL 431 wild Malaysian ...

P34535       645 VASa--------------lPVAVNTVGMTTFDLLGSHSSLQWLGsF--RVVVAYNTLFVVLSVAFLFNQL 698 Caenorhabditis elegans
EXX64430     443 ISSs--------------wPVLVRVLGLTRLSSAGPYENFSTMTnIgqYLAMAFRVSALITTVFSTLEYY 498 Rhizophagus irregularis D...
EEC43650     465 CALpavqfsqaafadyaafAEIRQIFGVQ----------IQFLQfF--SFFWTNNVFIYCFLAFTVLTSI 522 Phaeodactylum tricornutum...
EFN58402     446 ATTasiqfctaafalyadgTAINDIFGNQ----------LSSIKgL--KYIYNENIFIYCLLGFMALTLV 503 Chlorella variabilis
BAJ85289     435 CSIsviqfcatafayyaqaTAAQEIFGHT----------LQSLRgI--KYLYKYNVFQYGFVALAILTLF 492 domesticated barley
Q9SR93       432 CSIsviqfcatafgyyaqaTAAQEIFGHT----------LQSLRgI--KYLYKYNVFQIGFVILAGLTFL 489 thale cress
EFJ32053     435 CSVsviqfcskafalyaraTTAQEIFGLT----------LESLRgI--KYLFRYNVFQIAFCVLSVVTLV 492 Selaginella moellendorffii
ESS30088     449 SCAavvqftarcfrdyshsTVAAWIFDVQ----------LLVLPfF--GFVFKYNIFIYIFLGIALISAC 506 Toxoplasma gondii VEG
CBZ50084     455 SCAavvqftarcfrdyshsTVAAWIFDVQ----------LLLLPfF--GFVFKYNIFIYIFLGVELISAF 512 Neospora caninum Liverpool
XP_009392724 432 CSIsviqfcasafayysqaTAAQEIFGHT----------LQSLRgI--KYLYKYNVFQYGFVGFAVLTLF 489 wild Malaysian banana
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