Conserved Protein Domain Family
ChaC

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pfam04752: ChaC (this model, PSSM-Id:368097 is obsolete and has been replaced by 398428)
ChaC-like protein
The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.
Statistics
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PSSM-Id: 368097
Aligned: 12 rows
Threshold Bit Score: 187.56
Created: 20-Mar-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P32656   8 IWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTDHRGTPANPGRVATLIPYediirqtaflknvnlysesapiqdp 87  Saccharomyces cerevis...
Q9CQG1   1 MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDp------------------------ 56  house mouse
Q9VYK7  74 VWIFGYGSLVWKTDFPYIDRRRGFVWGFKRRFYQHSIDHRGIPERPGRVVTLLPgdp----------------------- 130 fruit fly
Q9VCI9  57 CWVFGYGSLCWHPGFNYTKCITGYIRGYVRRFWQGNVTHRGCEEKPGRVATLVEDk------------------------ 112 fruit fly
Q8R3J5  34 LWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDr------------------------ 89  house mouse
Q9GZE8  50 LWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEEt------------------------ 105 Caenorhabditis elegans
P39163  47 VWIFGYGSLMWNPALEFTESCTGTLVGWHRAFCLRLTAGRGTAHQPGRMLALKEG------------------------- 101 Escherichia coli K-12
Q9A674  10 RWVFGYGSLMWRPGFPFIDRRTAVLHGRRRAFCIYSVHHRGTYERPGLVLGLAPG------------------------- 64  Caulobacter vibrioides
Q98G14  15 FWVFGYGSLIWRPGFAHVETRRAHLHGYRRSLCVYSFVHRGTRERPGLVLGLDHG------------------------- 69  Mesorhizobium loti
Q98IT6  66 LKLFAYGSLLWKPAGEVRGGERAVARGWHRSFCFTVQRFRGTLEQPGLMMALDRG------------------------- 120 Mesorhizobium loti
Q98K42  55 LWVFAYGSLIWKPEFESVEQRLATAFGWHRSFCLDMVRWRGSAAQPGLMMALERg------------------------- 109 Mesorhizobium loti
P87305  10 LWVFGYGSLIWHPPPHYDYSIPCFIKGYVRRFWMRSEDHRGTVNSPGLVLTLIPYeewkqfsd------------wsftp 77  Schizosaccharomyces p...
P32656  88 ddLVTIGVVYYIPPEHA-QEVREYLNVREQ--NGYTLHEVEVHLetnreheaelgealeqlpRHNKSGKRvlLTSVYIGT 164 Saccharomyces cerevis...
Q9CQG1  57 -gGSVWGVAYKLPVGKE-EEVKTYLDFREK--GGYRTTTVIFYP------------------KDSTTKPF--SVLLYIGT 112 house mouse
Q9VYK7 131 aqDRVYGVAYRIAASQK-GAVLDHLDYREK--NGYERCSLEFHEy-----------------PTDGAEPI--QVIMYVAT 188 fruit fly
Q9VCI9 113 -eGITWGCAYRITGST----ALDYLKQRECtlGGYATIDTKFFPrv--------------asQDTPFSGEavEVLVYVAT 173 fruit fly
Q8R3J5  90 -eGCTWGVAYQVRGEQV-NEALKYLNVREAvlGGYDTKEVTFYP------------------QDTPDQPL--TALAYVAT 147 house mouse
Q9GZE8 106 -nSYTNGVVFRVDGKSAiATAVKYLEQRECd-NGYAFRMVPVQIr-----------------SAAHRRPTvvMALTCVAD 166 Caenorhabditis elegans
P39163 102 --GRTTGVAYRLPEETL-EQELTLLWKREMitGcylpt-------------------wcqldLD-DGRTV--NAIVFIMD 156 Escherichia coli K-12
Q9A674  65 --GSVRGMAYRVAAAEW-EGVYAYLREREQptEtyfet-------------------wrevkVD-GGDKA--PALVFLSD 119 Caulobacter vibrioides
Q98G14  70 --GSCVGLAFRVPGELR-DEVIAYLRERELvtSvyler-------------------alkvrLD-GGGTV--EAVAYIVD 124 Mesorhizobium loti
Q98IT6 121 --GQCQGMVFEIAAPVA-EN-LEALLRREMt--iLPAVNVPRW-------------------LQVSTEGGasRALGFVVD 175 Mesorhizobium loti
Q98K42 110 --GRCNGVIYRLPEGEK-PAQIERLLRREIsdH-ESVSSVRWLP--------------------VHTAQGalRALGFWVG 165 Mesorhizobium loti
P87305  78 fdEGCWGMAFRIPAKYA-TQVREYLDDREv--NGYTAHSVPVYA------------------HTGDEIPVleNCLVYVGT 136 Schizosaccharomyces p...
P32656 165 IDNEAFVGPE-TVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPimkerGrITDHYLTALLETVNKY 231 Saccharomyces cerevisiae S288C
Q9CQG1 113 CDNPNYLGPA-PLEDIAEQIFNAAGPSGRNTEYLFELADSVRKLVp----E-DADEHLFSLEKLVKER 174 house mouse
Q9VYK7 189 QANDSYAGDVwQVPCIARQIFSSAGPSGPNREYLFNLAAAMDQLf----pG-AVDEHLEELVACVKRY 251 fruit fly
Q9VCI9 174 PENIYWLGDD-PVEEIAQQIVSCRGPSGHNAEYLLRLALFMHEEIp----G-VRDDHLFELEQLVLEE 235 fruit fly
Q8R3J5 148 PQNPGYLGPA-PEEVIATQILACRGFSGHNLEYLLRLADFMQLCG-----PqAQDEHLEAIVDAVGTL 209 house mouse
Q9GZE8 167 qQNELYLGPD-DLIKMAREIVTAKGCAGPNCEYVLNLAENLRKLFp----N-DEDDHLFQLEHHVRIA 228 Caenorhabditis elegans
P39163 157 PRHPEYESDT-RAQVIAPLIAAASGPLGTNAQYLFSLEQELIKLG-------MQDDGLNDLLVSVKKL 216 Escherichia coli K-12
Q9A674 120 MKHSQWAGDL-TLEQQAALIAGAVGLSGPNIDYLRDLVMHLHEDG-------VRDHAMEKLLKMVEAR 179 Caulobacter vibrioides
Q98G14 125 RKHEQYAGAL-DAAHAAAVVRGAVGQSGNNEDYVFSTLKHLEALG-------IRDHWLEDVARGIAPS 184 Mesorhizobium loti
Q98IT6 176 PANPRYAGKL-DKSAVAATLARAVGHWGSGAQYLFETIRHLDACg-------IRDRNLWQLQELVAQE 235 Mesorhizobium loti
Q98K42 166 VKGRGTSPGQ-PLDRVASILARACGHIGSGAEYLYNTVSHLEAFG-------IHDRNLWRLQELVADE 225 Mesorhizobium loti
P87305 137 sKSPQFQPSD-DLTQMAKIISTRRGKSGDNFVYLFELAKCLRHLSp----E-SKDIHVFELEAEVRKQ 198 Schizosaccharomyces pombe 972h-
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