6BK5


Conserved Protein Domain Family
Cbl_N
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pfam02262: Cbl_N (this model, PSSM-Id:367006 is obsolete and has been replaced by 426685)
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CBL proto-oncogene N-terminal domain 1
Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.
Links
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Statistics
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PSSM-Id: 367006
Aligned: 34 rows
Threshold Bit Score: 140.787
Created: 30-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BK5_A        39 RTTSRIEKATRKLLTLCSNKRlkLKNSPPYLQGILFDTNDFFRRIFSLN-------TLDT------LRDCPYLNLAVRKY 105 Salpingoeca ros...
NP_001121724  33 KLLEKVLKRLDKLHKLSVDPRlaLKNSPPYLPELLSETAIHLTEVWAPYr-----gSAMAvp---rWDEGDYMRIHIRHL 104 zebrafish
XP_007249631  32 KLLEKALKKLSKLHTLCTDSRlgLKNSPPYLPDLVSETVILLTEVWDPYr-----gPAPAvp---rGDEADFLKIHVRHL 103 Mexican tetra
5_pfamImport   4 LLVDKLLKRLVKLRHLCANARlgLRLSPPYLPELVSDTAALLTQVWEPYr-----gPGAAggraprGDEAEYLRVHARNL 78 
XP_005463987  25 RLVDKTLRRLDKLQQLCSTPRlgLRNSPPYLPQLVSETSALLIQVWEPFq-----dFRAAgeqvphGDEAEYLRIHIKNL 99  Nile tilapia
EDL23196      16 RALSRAVKLLQRLEEQCRDPR--MVTGPPSLRDLLPRTAQLLGEVAKARre----aREDPeg---pGGADDFLAIYLANL 86  house mouse
XP_020565939  26 QMVDKSLKKLDRLHNLCTNPRlgLKNSPPYLPDLVRETLTLLHQVWEPYl-----gYSSAggqfprGDEATYLGVHVRNL 100 Japanese medaka
XP_027865682  25 RLMEKTLKRLERLSELCTNPRlgLRNSPPFLPDLVRETSTLLTQVWLPYq-----gVRTGgglaprGDEARYMRIHIRNL 99  Monterrey platy...
XP_023398927  17 RALGRVVKLLERLEAHCGDPR--LASSPPSLRDLLPRTAQLLRKVTLARra---egGRCLev---pGGAWDFLAIYLANL 88  African savanna...
XP_013002334  16 RALGRAVRLLQSLEEQCGDPR--LAMGPPSLRDLLPSTVRLLRAVARVRhdagpggSEGP------GGAWNFLQVFLANL 87  domestic guinea...

6BK5_A       106 LIHCRIATKLFR-----DAGEEMESEDSEYRRQLNKYTLVFSHMLADLQAVYKDGH 156 Salpingoeca rosetta
NP_001121724 105 LDKTDRAVLLFk-----EGKEKMFEETSNYRRNLTKLSLLFSHMLNELRTIFPGGR 155 zebrafish
XP_007249631 104 LDKTNRAILLFk-----EGKDKMFEERSSYRRNLTKLSLLFSHMLWELRAMFPDGR 154 Mexican tetra
5_pfamImport  79 LDKTERALLLFk-----EGREKMFDETSSCRRNLTKLSLLFSHMLWELRAVFPGGG 129
XP_005463987 100 FDKTERAVLLFk-----EGRRKIYEETSTYRRNLTKLTLLFSHMLWELKAFFPGGC 150 Nile tilapia
EDL23196      87 EVKGRQVAELLPprgkkDVNQDVFREGSRFRRQLAKLALIFSHMHAELSALFPAGK 142 house mouse
XP_020565939 101 LDKTEKAMLLFk-----DGREKIFDETSSCRRNLTKLSLLFSHMLWELKAMFPGGH 151 Japanese medaka
XP_027865682 100 LDKTDRAVLLFk-----EGREKIFDETSSYRRNLTKLSLLFSHMLWELKAMFPGGY 150 Monterrey platyfish
XP_023398927  89 EAKGRQVAMLLPprgrtEANDELFREGSRLRRQLAKLALIFSHMHAELDALFPGGQ 144 African savanna elephant
XP_013002334  88 EAKAKQVAGLLPgrgrrGASDDLFLEGSRLRQQLAKLALIFSHMHAELGALFPKGK 143 domestic guinea pig
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