6FKM,3NVN,5B4W,5L5K,5L5G


Conserved Protein Domain Family
PSI

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pfam01437: PSI (this model, PSSM-Id:366642 is obsolete and has been replaced by 396154)
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Plexin repeat
A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
Statistics
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PSSM-Id: 366642
Aligned: 100 rows
Threshold Bit Score: 29.9968
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6FKM_A  498 DCSDY-KTCGD-CLGardPYCGWCSLENKCSP-RSNC--QDDANDPLYWVSYKtg---kCT 550  fruit fly
Q62179  512 NCSLY-PTCGD-CLLardPYCAWT--GSACRL-ASLY---QPDLASRPWTQDIe----gAS 560  house mouse
Q9NPR2  520 NCSLY-RSCGD-CLLardPYCAWS--GSSCKH-VSLY---QPQLATRPWIQDIe----gAS 568  human
O09126  502 FCEKH-GSCED-CVLardPYCAWSPAIKACVTl------HQEEASSRGWIQDMsgdtssCL 554  house mouse
Q92854  502 FCGKH-GTCED-CVLardPYCAWSPPTATCVAl------HQTESPSRGLIQEMsgdasvCP 554  human
Q9J5F6  433 FCHLYgGTCDS-CLLsrdPHCGWT--NIDCVY-------GGEKKLlqkdiydvpknicsgs 483  Fowlpox virus
Q9BXR8  530 RCQQY-SGCMKnCIGsqdPYCGWAP-DGSCIF--------LSPGTRAAFEQDVsgastsgl 580  human
Q8NFY4  514 RCERY-GSCKKsCIAsrdPYCGWLS-QGSCGRvTPGMlaEGYEQDTEFGNTAHlg---dCH 569  human
Q76KF0  514 RCERY-GSCKKsCIAsrdPYCGWLS-QGVCERvTLGMlpGGYEQDTEYGNTAHlg---dCH 569  house mouse
Q8BKG8  514 RCERY-GSCKKsCIAsrdPYCGWLSQGV-CERvTLGMlpGGYEQDTEYGNTAHlg---dCH 569  house mouse
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