1XQ8


Conserved Protein Domain Family
Synuclein
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pfam01387: Synuclein (this model, PSSM-Id:366607 is obsolete and has been replaced by 460186)
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Synuclein
There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.
Links
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Statistics
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PSSM-Id: 366607
Aligned: 15 rows
Threshold Bit Score: 119.693
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1XQ8_A         1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQK 80  human
Q28F65         1 MDVFKKGFSMAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGAKTKEGVVHSVSTVAEKTKEQANVVGGAVVSGVNQVASK 80  tropical clawed...
XP_011602812   1 MDAFMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMFVGTKTKDG----VTVVAGKTVSGVSQVGGAMVTGVTAVAQK 76  torafugu
XP_003455005   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VTTVAGKTVSGVSQVGEAVVTGVTAVAQK 76  Nile tilapia
XP_017825906   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQK 80  white-tufted-ea...
2_pfamImport   1 MDMFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSEIRSK---------DRARGSGSVVRDQSNESTEGITMG 71 
XP_015203361   1 MDVLKKGFSIAKEGVVAAAEKTKQGVEEAAAKTKEGVMYVGTKTKEGVVHSVNTVAQKTTEQANIVGETVVGSANQVSAK 80  spotted gar
XP_012321796   1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGVVQGVASVAEKTKEQASHLGGAVFS-------- 72  Ma's night monkey
XP_005812724   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VSTVAEKTVSGVSHVGGAVVTGVTAVAQK 76  southern platyfish
AWP15373       1 MEAFKKGFSMAREGVAAAAEKTKQGVTGAAEMTKDGVMFVGTKTKDG----VTTVAGKTVSGVSQVSGAMVTGVTAVAQK 76  turbot

1XQ8_A        81 TVEGAGSIAAATG--FVKKDQLG----KNEEGAPqegile-dmpvdpDNEAYEMPSEE 131 human
Q28F65        81 TVEGTENIVGTTG--LVKKEDLHpg-qPEEPAAE-------------EEPAVEATEST 122 tropical clawed frog
XP_011602812  77 TVESAGSIAAATG--LVKKE-------PGKQGDDaataen-maespdVTDPAEATEED 124 torafugu
XP_003455005  77 TVEGAGTIAAATG--LVKKD-------PAKQSDDasavqd-vaespvDTDPADVTEED 124 Nile tilapia
XP_017825906  81 TVEGAGNIAAATG--FVKKDHLG----KSEEGAPqegile-dmpvdpDNEAYEMPSEE 131 white-tufted-ear marmoset
2_pfamImport  72 GIRGDDGSSVGVGrvLVKSSQWWhg-iPEEVGQEvgeepmaeplldtEGESYEEPPQE 128
XP_015203361  81 TVEGVENVVASTG--VVNPDDAV----NQEDFSRp-----------pEGTVEQATDAV 121 spotted gar
XP_012321796  73 ---GAGNIAAATG--LVKREEFPtdlkPEEVAQEaaeeplieplmepEGESYEDPPQv 125 Ma's night monkey
XP_005812724  77 TVEGAGNIAAATG--LVKKD-------PAKQGEDvsavpd-avespiDTDSTEPTEED 124 southern platyfish
AWP15373      77 TVEGAGNIVAATG--LVKKD-------PAKQSDEalaeqn-maespvDTDPADATEed 124 turbot
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