Conserved Protein Domain Family
ELO

?
pfam01151: ELO (this model, PSSM-Id:366492 is obsolete and has been replaced by 460083)
GNS1/SUR4 family
Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.
Statistics
?
PSSM-Id: 366492
Aligned: 149 rows
Threshold Bit Score: 108.115
Created: 24-Apr-2019
Updated: 18-Jul-2019
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q0V0L4    54 ALAYKVPLAISTVYAITV-TYFNWYNR----QHanKPWris----------ktrPFFAFVIFHNVFLAVYSAITCVAMVr 118 Parastagonospora no...
CAP33333  12 NVSFIPIHLLGILYVFIAfNFRPSHNS----DR---SY-----------------LKEWYYFNCIFQLVLGLLMIPEIL- 66  Caenorhabditis brig...
CAM37531  21 LKNIDLVGYIASFYLVMV-GKGDRILSwwnaRK--PLApnaaakqngankemvaALKSCYTAASMYHLVVSIAGAAISCm 97  Leishmania brazilie...
O35949    32 EEYWVSSFLIVVVYLLLI-VVGQTYMR----TR--KSF----------------SLQRPLILWSFFLAIFSILGTLRMW- 87  house mouse
Q9HB03    31 EEYWATSFPIALIYLVLI-AVGQNYMK----ER--KGF----------------NLQGPLILWSFCLAIFSILGAVRMW- 86  human
CAP37153  41 ADHFDVTIQASILYMVVV-FGTKWFMR----NR--QPF----------------QLTVPLNIWNFILAAFSIAGAIKMT- 96  Caenorhabditis brig...
CAP37099  25 AQTQWPAFWISMAYVVVI-FGIKAAMV----NR--KPF----------------DLTGPLNYWNAALAIFSTAGSVFTS- 80  Caenorhabditis brig...
Q20300    20 RGLEGFSAKLAVGYIATI-FGLKYYMK----DR--KAF----------------DLSTPLNIWNGILSTFSLLGFLFTF- 75  Caenorhabditis elegans
CAP37155  63 HEHFGLFVQMTIAYVIVI-FSIKRCMR----DR--EPF----------------KLTNALRFWNFFLSVFSIYGSWAMF- 118 Caenorhabditis brig...
CAP21889  29 STFVPLSYKIMVGYLITI-YFGQKLMA----HR--KPF----------------DLQNTLALWNFGFSLFSGIAAYKLI- 84  Caenorhabditis brig...
Q0V0L4   119 alKtsfpHYSDPNsv-vGTVDALckingprglgdavtynsttntwasknsnvlvdsttglpdpSDVGRIWNE-GLAFWGW 196 Parastagonospora no...
CAP33333  67 -------ISLFSG-----WHYSVc----------------------------------------QAGSLYTGfLSGTVVF 94  Caenorhabditis brig...
CAM37531  98 lvPamaqSLLANS-----FFEVMc--------------------------------------lWDDTRIYKG-YVAFALS 133 Leishmania brazilie...
O35949    88 -------KFMATVmftvGLKQTVc----------------------------------------FAIYTDDA-VVRFWSF 119 house mouse
Q9HB03    87 -------GIMGTVlltgGLKQTVc----------------------------------------FINFIDNS-TVKFWSW 118 human
CAP37153  97 --P----EFFGTIan-kGLVASYc----------------------------------------KVFDFTKG-ENGYWVW 128 Caenorhabditis brig...
CAP37099  81 --F----GLLHEFvt-rGFFESYi----------------------------------------HIGDFYNG-FSGFFTW 112 Caenorhabditis brig...
Q20300    76 --P----TLLSVIrk-dGFSHTYs---------------------------------------HVSELYTDS-TSGYWIF 108 Caenorhabditis elegans
CAP37155 119 --P----FMVEQIrr-fGLYGCGc----------------------------------------EALSTLPS-QAEYWLF 150 Caenorhabditis brig...
CAP21889  85 --P----ELVSVFmk-dGFVASYc---------------------------------------QNETYYTDP-STGFWGW 117 Caenorhabditis brig...
Q0V0L4   197 WFYLSKFYEVLDTAIILAK----------GK---RSTTLQKYHHAGAMLSMWAGMRFM-APPIWMFVLVNSGIHAMMYTY 262 Parastagonospora no...
CAP33333  95 IWTITKIVDLFETLLLLYD----------AR---RPLTIHIIHHFLSLSYAFTFYSQN-FAIHRWIVFFNLTAHVFLYAY 160 Caenorhabditis brig...
CAM37531 134 AAVMVKVVEQLDTFFLILRdyivaspaqkEKqvrRVQPSHWWFQGLIALYFWHTYSIG-TSCFTMIATLTMVMSAARNFV 212 Leishmania brazilie...
O35949   120 LFLLSKVVELGDTAFIILR----------KR---PLIFVHWYHHSTVLLFTSFGYKNKvPSGGWFM-TMNFGVHSVMYTY 185 house mouse
Q9HB03   119 VFLLSKVIELGDTAFIILR----------KR---PLIFIHWYHHSTVLVYTSFGYKNKvPAGGWFV-TMNFGVHAIMYTY 184 human
CAP37153 129 LFMASKLFELVDTVFLVLR----------KR---PLMFLHWYHHILTMIYAWYSHPLTpGFNRYGI-YLNFVVHAFMYSY 194 Caenorhabditis brig...
CAP37099 113 LFVLSKVAEFGDTLFIVLR----------KK---PLMFLHWYHHVLTMNYAFMSFEANlGFNTWIT-WMNFSVHSIMYGY 178 Caenorhabditis brig...
Q20300   109 LWVISKIPELLDTVFIVLR----------KR---PLIFMHWYHHALTGYYALVCYHED-AVHMVWVVWMNYIIHAFMYGY 174 Caenorhabditis elegans
CAP37155 151 LTVLSKALEFVDTFFLVLR----------KK---PLIFLHWYHHVATFLFFCVTYPTP-SSQIRVGAIVNLFVHAFMYPY 216 Caenorhabditis brig...
CAP21889 118 AFVMSKAPELGDTMFLVLR----------KK---PVIFMHWYHHALTFVYAVVTYSEHqAWARWSL-ALNLAVHTIMYFY 183 Caenorhabditis brig...
Q0V0L4   263 YTVSa-----lGYRVPNvvKRTLTTLQITQFLVGSaYAAIHLFVSYTIPvtvahqivekvapklnsssissavssatssa 337 Parastagonospora no...
CAP33333 161 lsg------ykILNRWTpcWVAVCSSQMLQLILPF-IATLFAAAKMTRG------------------------------- 202 Caenorhabditis brig...
CAM37531 213 YMQQdtaqahgKSAAAVklNSAIVALDMMEWIGCSaLSVYASLMNYTDK------------------------------- 261 Leishmania brazilie...
O35949   186 YTMKaak---lkHPNLL--PMVITSLQILQMVLGT-IFGILNYIWRQEKgc----------------------------- 230 house mouse
Q9HB03   185 YTLKaan---vkPPKML--PMLITSLQILQMFVGA-IVSILTYIWRQDQgc----------------------------- 229 human
CAP37153 195 YFLRsmk---irVPGVI--AQAITSLQILQFIISC-AVLAHLGYLMHFTn------------------------------ 238 Caenorhabditis brig...
CAP37099 179 YMLRsfg---vkVPAWI--ARNITTMQILQFVITH-FILFHVGYLAMTGqs----------------------------- 223 Caenorhabditis brig...
Q20300   175 YLLKslk---vpIPPSV--AQAITTSQMVQFAVAI-FAQVHVSYKHYVEgve---------------------------- 220 Caenorhabditis elegans
CAP37155 217 YFIRsmn---ikLPAKI--SMAVTVLQLTQFVCFI-YGCTLMYYSLATNq------------------------------ 260 Caenorhabditis brig...
CAP21889 184 FAVRaln---iqTPRPV--AKFITTIQIVQFVISC-YIFGHLVFIKSANs------------------------------ 227 Caenorhabditis brig...
Q0V0L4   338 vaalptatgpalaflrkliyraagdeglaeniavpgeplpyyqqqqalaagqrpehpveqlfhrpqetvnrviyrteyqs 417 Parastagonospora no...
CAP33333     --------------------------------------------------------------------------------     Caenorhabditis brig...
CAM37531     --------------------------------------------------------------------------------     Leishmania brazilie...
O35949       --------------------------------------------------------------------------------     house mouse
Q9HB03       --------------------------------------------------------------------------------     human
CAP37153     --------------------------------------------------------------------------------     Caenorhabditis brig...
CAP37099     --------------------------------------------------------------------------------     Caenorhabditis brig...
Q20300       --------------------------------------------------------------------------------     Caenorhabditis elegans
CAP37155     --------------------------------------------------------------------------------     Caenorhabditis brig...
CAP21889 228 -------------------------------------------------------------------------------v 228 Caenorhabditis brig...
Q0V0L4   418 VpcidTSgQAF--AIYLNLIYLAPLTFLFMRFFF-KSY--LRRTSP 458 Parastagonospora nodorum SN15
CAP33333 203 TqcdaNAlGIFtlQIGLSV-----MILLFADFYWsRLQefRRKNMK 243 Caenorhabditis briggsae
CAM37531 262 Rg-----cMTMqaNVRMALVMYVTAVVLRLRELI-KGAegLAARES 301 Leishmania braziliensis MHOM/BR/75/M2904
O35949   231 ----hTTt----eHFFWSFMLYGTYFILFAHFFH-RAY--LRPKGK 265 house mouse
Q9HB03   230 ----hTTm----eHLFWSFILYMTYFILFAHFFC-QTY--IRPKVK 264 human
CAP37153 239 Anc-dFDp----sVFKLAVFMDTTYLALFINFFL-QSY--VLRGGK 276 Caenorhabditis briggsae
CAP37099 224 ---vdSTt----gYYWFCLLMEISYVVLFGNFYY-QSY--IKGGGK 259 Caenorhabditis briggsae
Q20300   221 --glaYSf----rGTAIGFFMLTTYFYLWIQFYK-EHY--LKNGGK 257 Caenorhabditis elegans
CAP37155 261 Ytc-dTPm----fALNSTFGLSLSYFVLFANFFH-KSY--LQRGGK 298 Caenorhabditis briggsae
CAP21889 229 Pgc-aVSw----nVLSIGGLMYISYLFLFAKFFY-KAY--IQKRSP 266 Caenorhabditis briggsae
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap