5J8R,5HDE


Conserved Protein Domain Family
PTPc-N12
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cd14604: PTPc-N12 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 12
Tyrosine-protein phosphatase non-receptor type 12 (PTPN12), also called PTP-PEST or protein-tyrosine phosphatase G1 (PTPG1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN12 is characterized as a tumor suppressor and a pivotal regulator of EGFR/HER2 signaling. It regulates various physiological processes, including cell migration, immune response, and neuronal activity, by dephosphorylating multiple substrates including HER2, FAK, PYK2, PSTPIP, WASP, p130Cas, paxillin, Shc, catenin, c-Abl, ArgBP2, p190RhoGAP, RhoGDI, cell adhesion kinase beta, and Rho GTPase.
Links
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Statistics
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PSSM-Id: 350452
Aligned: 7 rows
Threshold Bit Score: 644.679
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 12 residue positions
Conserved feature residue pattern:x x C x x x x x R x x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:5HDE: Human PTPN12 binds a phosphate ion in the active site; contacts at 4A
    - View structure with Cn3D
  • Comment:also based on the structures of human PTPN22 and PTPN18 with bound phosphopeptide substrates
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
5J8R_A         8 EQVEILRKFIQRVQAMkspdhngedNFARDFMRLRRLSTKYRTekiYPTATGEKEENVKRNRYKDilpfDHSRVKLTLKT 87  human
5HDE_A         8 EQVEILRKFIQRVQAMkspdhngedNFARDFMRLRRLSTKYRTekiYPTATGEKEENVKKNRYKDilpfDHSRVKLTLKT 87  human
NP_001084841   2 DQVAILKSFIQRVQEMdmkdhngedNFACDFMKLRRLSTKYRTdkiYPTINGEREENVKKNRYKDilpfDHSRVRLALKV 81  African clawed ...
XP_415970      2 SQEEILRKFIKRVQAMkdtdhngedNFASDFMRLRRLSTKYRTekiYPTATGEKEENVKKNRYKDilpfDHSRVKLTLKT 81  chicken
NP_956963      2 EQGNILKKFIEELRSGeqt---gedNFSSDFMRLRRLSTKYRTekiYPTDVGEQEENVKKNRYKDilpfDHSRVKVTLKT 78  zebrafish
XP_006004234   2 DQVEILKKFIERVQAMktrdqngedNYASDFMRLRRLSTKYRTekiYPTNFGEKEENVKKNRYKDilpfDHSRVKLTLKL 81  coelacanth
XP_007889095   2 EQAEILKRFIERVQAMkvrdqngedNFANDFMRLRRLSTKYRTekiYPTNTGEKEENVKKNRYKDilpfDHSRVKLALKT 81  elephant shark

Feature 1                                                                                        
5J8R_A        88 PSQdsdYINANFIKGvygpkAYVATQGPlantviDFWRMIWEYnvVIIVMACREFEMGRKKCERYWPLYGedpitfapFK 167 human
5HDE_A        88 PSQdsdYINANFIKGvygpkAYVATQGPlantviDFWRMIWEYnvVIIVMACREFEMGRKKCERYWPLYGedpitfapFK 167 human
NP_001084841  82 QSHesdYINANFIKGvhgpkAYIATQGPlantviDFWRMIWEYnvAIIVMACREFEMGRKKCERYYPNYGeqpvtfgsFH 161 African clawed ...
XP_415970     82 PPQdsdYINANFIKGvhgpkAYVATQGPlantviDFWRMIWEYnvAIIVMACREFEMGRKKCERYWPLYGeaavtfgpFR 161 chicken
NP_956963     79 SNQdtdYINANFIKGidgpqAYIATQGPlpntvlDFWRMIWEYkvAVIVMACREFEMGRKKCERYFPLFGdepmtfgpFR 158 zebrafish
XP_006004234  82 SSQdtdYINANFIKGvrdprAYIATQGPlantviDFWRMIWEYnvVVIVMACREFEMGRKKCERYCSPYGeepmsfgpFH 161 coelacanth
XP_007889095  82 SQVdsdYINANFIKGvygpnSYIATQGPlantvlDFWRMIWEYnvAIIVVACREFEMGRKKCERYWPIHGdgplrlgeFL 161 elephant shark

Feature 1                                             ##                              #######    
5J8R_A       168 ISCEDEQARtdYFIRTLLLEfqnesRRLYQFHYVNWPDHDVPssFDSILDMISLMRKYQEHedvPICIHCSAGCGRTGAI 247 human
5HDE_A       168 ISCEDEQARtdYFIRTLLLEfqnesRRLYQFHYVNWPDHDVPssFDSILDMISLMRKYQEHedvPICIHXSAGCGRTGAI 247 human
NP_001084841 162 ISCESEESRkdYFVRTLLLEfqnetHTIHQFHYVNWPDHDVPssFDSILDMIGLMRHYQAHddvPLCIHCSAGCGRTGAI 241 African clawed ...
XP_415970    162 VSCEAEQARtdYFIRTLLLEfqnetRSVYQFHYVNWPDHDVPssFDSILDMISLMREYQEHedvPICIHCSAGCGRTGAI 241 chicken
NP_956963    159 ISCESEQPRtdYCVRTLTVEfdqecRRLTQFHYVNWPDHDVPssFDSILDMIELMRKHQQRdttPICVHCSAGCGRTGAI 238 zebrafish
XP_006004234 162 ISCEAEQARtdYFIRTLLVEfqnetHRIYQFHYVNWPDHDVPssFDSILDMISLMREYQEHedvPICVHCSAGCGRTGAI 241 coelacanth
XP_007889095 162 VTCEAEQARndYFIRTLLVEfqnesRRLYQFHYINWPDHDVPssFDSILDMISLMREYQDHekvPICIHCSAGCGRTGAI 241 elephant shark

Feature 1                                         #  ##                   
5J8R_A       248 CAIDYTWNLLKagkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL 304 human
5HDE_A       248 CAIDYTWNLLKagkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL 304 human
NP_001084841 242 CAIDYTWNLLKagiiPEKFNVYSLIQEMRTQRHSAVQTKEQYELVHRAIAQLFQKQL 298 African clawed frog
XP_415970    242 CAIDYTWNLLKagkiPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQL 298 chicken
NP_956963    239 CAIDYTWNLLKagriSEDFNVFQLIQEMRTQRHSAVQTKEQYELVHRAIAQIFQKQL 295 zebrafish
XP_006004234 242 CAIDYTWNLLKagkiPEDFNVYNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFGKQV 298 coelacanth
XP_007889095 242 CAIDYTWNLLKagkiPEEFSVYSLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKEL 298 elephant shark

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