5N21,4CP3,5N1Z,5N1X,4U2M,1R2B,3BIM,4CP3


Conserved Protein Domain Family
BTB_POZ_ZBTB27_BCL6
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cd18331: BTB_POZ_ZBTB27_BCL6 
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BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)
BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
Links
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Statistics
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PSSM-Id: 349640
Aligned: 13 rows
Threshold Bit Score: 216.647
Created: 14-Sep-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5N21: Homo sapiens BCL6 forms a homodimer, contacts at 4A.
    - View structure with Cn3D
  • Comment:Homo-dimerization is a common property of BTB-zinc finger proteins.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ####  ### ## ##  #  # ##              ###  ###    #        #                    
5N21_A         2 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 81  human
4CP3_A         4 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 83  human
5N1Z_A         3 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 82  human
5N1X_D         1 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 80  human
4U2M_A       135 CIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILL 214 human
1R2B_A         6 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 85  human
3BIM_A         6 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 85  human
4CP3_B         4 QIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKRNLSVINLDPEINPEGFNILL 83  human
NP_957028      8 CIQFTRHASDVLLNLNRLRSRDILTDVTILVNRQQFRAHKTVLMACSGLFYSIFTDSHKCNLNAISLDPKVDPEGFAILL 87  zebrafish
Q5ZM39         8 CIQFTRHASDVLLNLNRLRSRDILTDVVIIVNREQFRAHKTVLMACSGLFYSIFTDQLKCNLNVINLDPEINPEGFCILL 87  chicken
NP_001116278  10 CIQFTRHANDVLLNLNRLRSRDILTDVIIVVEGEHFRAHKTVLMACSGLFYAIFTDQMKCNSNIINLNTDVSAEGFRVLL 89  western clawed ...
XP_005992514   8 CIQFTRHASDVLLNLNRLRSRDILTDVAILINGEQFRAHKTVLMACSGLFYSIFTDQMKCNMSVITLAPEVNAEGFGILL 87  coelacanth
XP_007883672  32 CIQFTRHASDVLLNLNRLRSRDILTDVTILVDRRHFRAHKTVLMACSGLFYTIFTDQMKFNLNVISLDPDVDPDGFGILL 111 elephant shark

Feature 1         ##  #####                  #   #     
5N21_A        82 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 119 human
4CP3_A        84 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 121 human
5N1Z_A        83 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 120 human
5N1X_D        81 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTARKFI 118 human
4U2M_A       215 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 252 human
1R2B_A        86 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 123 human
3BIM_A        86 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 123 human
4CP3_B        84 DFMYTSRLNLREgnIMAVMATAMYLQMEHVVDTCRKFI 121 human
NP_957028     88 EFMYTSRLALKEslIMAIMNTAIYLQMDHVVDTCHRFI 125 zebrafish
Q5ZM39        88 DFMYTSRLNLREnnIMAVMATALYLQMEHVVDTCRRFV 125 chicken
NP_001116278  90 DFMYTSRLNLRDssIMAVMSTALYLQMEHVVDTCQRFL 127 western clawed frog
XP_005992514  88 DFMYTSRLALSDssILAVLNTAVYLRMDHVVGTCHRFL 125 coelacanth
XP_007883672 112 DFMYTSRLPLRDssIMLVMNTALYLQMDHVVSTCHRFL 149 elephant shark

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