2VXC,1GZH,5ECG,1KZY,2VXB


Conserved Protein Domain Family
BRCT_p53bp1_rpt1
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cd17745: BRCT_p53bp1_rpt1 
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first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
p53BP1, also termed 53BP1, or TP53-binding protein 1 (TP53BP1) , is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. TP53BP1 contains two tandem BRCT repeats. This family also includes Schizosaccharomyces pombe Crb2, which is a checkpoint mediator required for the cellular response to DNA damage. This model corresponds to the first BRCT domain.
Links
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Statistics
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PSSM-Id: 349376
Aligned: 64 rows
Threshold Bit Score: 63.8692
Created: 5-May-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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p53 interactiongamma-H2ABRCT sequence
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:p53 interaction site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
2VXC_A          3 IFDDCVFAFSGPVheda--------------------------ydrSALETVVQDhGGLVLDTGLRplfndpfkskqkk- 55   fission yeast
1KZY_C         15 LFLGYAFLLTMATtsdklasrsklpdgptgsseeeeefleippfnkQYTESQLRAgAGYILEDFNEaqc----------- 83   human
XP_006689405  596 VFSNCLFCITSLNed-----------------------------tkGQLIKIIYAnGGDVVEDGFMelfeyrrknkle-- 644  Candida tenui...
ODV85991     1141 PFESCVFVITSLSsnrssl---------------------iteetlKIIEKFITKnGGCVINDSLEnwiqks-------- 1191 Candida arabi...
EIF45910      223 CFKNCLFLMTMPTgsndhl----------------------sdeqlSKVESFLKDnGATIVSEFEKyixiskcghxgsg- 279  Dekkera bruxe...
EJU05264     1099 VFEGHAFIVTAKEdk-----------------------------tkAELVRQIEQaSGQVAEDFGDyfdvteqhi----- 1144 Dacryopinax p...
AJU63613      998 VFDKCIFVLTSLFen------------------------------rEELRQTIESqGGTVIESGFStlfnfthplakslv 1047 Saccharomyces...
AOW06221      760 VFEGCIFLVTSTEdkp---------------------------serTQLINAITAgGGTIHEDFVSlfqwengep----- 807  Yarrowia lipo...
OEJ82935      885 LFAGCLFLFTGIDev-----------------------------lkNRIAESIVKhAGIYIPNEISsvlnynpttdamel 935  Hanseniaspora...
CDK26809      583 IFQGYCFCFTRSGvdne--------------------------edfKRRTQFILDsGGVILENGFTellepssdls---- 632  Kuraishia cap...

Feature 1                                                              # #   #  #   
2VXC_A         56 -------------lrhlkpqkrskswNQAFVVSDTFSRKVKYLEALAfNIPCVHPQFIKQCLKMNR 108  fission yeast
1KZY_C         84 -----------------------ntaYQCLLIADQHCRTRKYFLCLAsGIPCVSHVWVHDSCHANQ 126  human
XP_006689405  645 ---------------lvlrdkesedlQFVALISNGISRSFKYLQTVAlGWPILSETFIFDTVERNQ 695  Candida tenuis ATCC 10573
ODV85991     1192 --------------------snlekfKFAALLSPTHIRTLKYLQFVTlSWPILSIKFILDLIEMEK 1237 Candida arabinofermentans N...
EIF45910      280 -------------sysmtfrsgvkkfNFVALLSTKQIRTLKYLQCLAlGWPILSFTFIFDCIDNPE 332  Dekkera bruxellensis AWRI1499
EJU05264     1145 -----------------twkgaerglIAVWCIAREVSTTPKYLMALAlGVPCLGSRFISDVIEKRT 1193 Dacryopinax primogenitus
AJU63613     1048 nkgntdnirelalkltwkphslfadyRFACLITKRHLRSLKYLETLAlGWPTLHWKFISACIEKKR 1113 Saccharomyces cerevisiae YJ...
AOW06221      808 -----------------tingkalsmRFGCVISNSHTRTPKYLQALSmGWPCLNTAFVNDVLGGTA 856  Yarrowia lipolytica
OEJ82935      936 -------------dknlenelgigkiRFIALITDQYRRSIKYIEMLAmGLPILHYQFIFDCFQSGS 988  Hanseniaspora osmophila
CDK26809      633 ----------------ftrhvslksfRLPLTLSNKPCRTEKYLQALAlGWPLLSEKFIDDCISNKE 682  Kuraishia capsulata CBS 1993

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