4N40


Conserved Protein Domain Family
BRCT_Ect2_rpt1
?
cd17733: BRCT_Ect2_rpt1 
first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.
Links
?
Statistics
?
PSSM-Id: 349365
Aligned: 19 rows
Threshold Bit Score: 122.049
Created: 4-Apr-2008
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
BRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1: BRCT sequence motif, 2 residue positions
Conserved feature residue pattern:W [CS]Click to see conserved feature residue pattern help
Evidence:
  • Comment:The Trp-X-X-X-Cys/Ser is considered a signature motif of the BRCT family.
  • Comment:Cys/Ser residue in BRCT sequence motif is not conserved in most family members.
  • Citation:PMID 9799248
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           #   #     
4N40_A       101 XXNLVLCFTGFRkkeeLVRLVTLVHHXGGVIRKDFNs-KVTHLVANCtqgEKFRVAVSLGTPIXKPEWIYKAWERRN 176  human
XP_013415818 123 MQNLIMCFTGFKqkaeLSKMADYVHHMGGSIRKDFSt-RVTHLVANCtggEKYRAAVSLGTPIMSSQWVQKAWEARD 198  Lingula anatina
ELU14128      73 MDQLVICFTGFKakedLSRLADLVHHMGGSLRKDFSc-RVTHLVANCtsgEKYRVAVSMGAPVMTEEWVFKVWDHRD 148  Capitella teleta
XP_002603575 109 MKDLILCFTGFRqkekLSHLVDLVHFMGGSIRKDFSt-KVTHLVANStsgDKYRVAVSLGTPIMTEEWVHQSWHRRH 184  Florida lancelet
XP_006824711 115 MSQLIICFTGFRnkaeITRLVNLVHHMGGSIRKDFSt-RVTHLVANTtngNKYRTAVSLGTPVMTEQWVHQAWSTRH 190  Saccoglossus kowa...
XP_781936    134 MDKLVICFTGFLdkaeIKRLVVLVHNMAGSIRKDYGp-RVTHLVANSsnsEKYRVAVSLGTPIMTKEWIQATWDNRH 209  purple sea urchin
KXJ26220     122 MANHIICFTGFKkkdeMGKLCNLVHHMGGSIRGELSg-RVTHLVACSvhgHKYGAAVSLGKPIMTVDWVYTCWEKRF 197  Exaiptasia pallida
KRZ70695     133 MKEVTVCFAGLHdkkvLSNVVDLVHHMGGSVRKNFTm-SVTHVVTNTtqsSKYRLAVGMGKSVMHVDWIFKMWERRS 208  Trichinella papuae
EFX75625     131 MENVVSCFTGFRnreeVNTLVSCIHHMGGSIRKEFDcnKITHLIANKvggEKYQYAVTFNIPVMNASWVHLAWEKRH 207  common water flea
XP_018671437  90 MQSLNLCFTNFKtkehLAHLVTLCHYMGACIRKDMSs-KIDFLVTNTlhgPKYRTAVSLGTPVMKEEWIHRCWAARN 165  vase tunicate

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap