4Z34


Conserved Protein Domain Family
7tmA_LPAR
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cd15101: 7tmA_LPAR 
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lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors
The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).
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Statistics
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PSSM-Id: 341325
Aligned: 4 rows
Threshold Bit Score: 423.462
Created: 21-Oct-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:putative antagonist binding pocket [chemical binding site]
Evidence:
  • Structure:4Z34: Human lysophosphatidic acid receptor 1 (LPAR1) binds an antagonist (Ono-9780307), contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #                                                 #      #   #          ##  ##
4Z34_A        68 KLVMGLGITVCIFIMLANLLVMVAIYVNRRfhfpIYYLMANLAAADFFAGLAYFYLMFNTgPNTRRLTvstWLLRQGLID 147
NP_001004502  32 KLVMGLGITVCIFIMLANLLVMVAIYINRRfhfpIYYLMANLAAADFFAGLAYFYLMFNTgPNTRRLTvstWLLRQGLID 111 zebrafish
Q9HBW0        33 VVVVALGLTVSVLVLLTNLLVIAAIASNRRfhqpIYYLLGNLAAADLFAGVAYLFLMFHTgPRTARLSlegWFLRQGLLD 112 human
Q9UBY5        31 VIVLCVGTFFCLFIFFSNSLVIAAVIKNRKfhfpFYYLLANLAAADFFAGIAYVFLMFNTgPVSKTLTvnrWFLRQGLLD 110 human

Feature 1          #                                                                          #  
4Z34_A       148 TSLTASVANLLAIAIERHITVFRMqlhtrmsNRRVVVVIVVIWTMAIVMGAIPsvgwnCICDIENCSnmaplYSDSYLVF 227
NP_001004502 112 TSLTASVANLLAIAIERHITVFRMqlhtrmsNRRVVVVIVIIWTMSIVMGAIPsvgwnCICAIDTCSnmaplYSNSYLGF 191 zebrafish
Q9HBW0       113 TSLTASVATLLAIAVERHRSVMAVqlhsrlpRGRVVMLIVGVWVAALGLGLLPahswhCLCALDRCSrmaplLSRSYLAV 192 human
Q9UBY5       111 SSLTASLTNLLVIAVERHMSIMRMrvhsnltKKRVTLLILLVWAIAIFMGAVPtlgwnCLCNISACSslapiYSRSYLVF 190 human

Feature 1        #                                                                               
4Z34_A       228 WAIFNLVTFVVMVVLYAHIFGYvadlednwetlndnlkviekadnaaqvkdaltkmraaaldaqkatppkledkspdspe 307
NP_001004502 192 WAIFNLVTFVVMVVLYAHIFMYvrqrtmrmsr------------------------------------------------ 223 zebrafish
Q9HBW0       193 WALSSLLVFLLMVAVYTRIFFYvrrrvqrmae------------------------------------------------ 224 human
Q9UBY5       191 WTVSNLMAFLIMVVVYLRIYVYvkrktnvlsp------------------------------------------------ 222 human

Feature 1                                                                                #  #  ##
4Z34_A       308 mkdfrhgfdilvgqiddalklanegkvkeaqaaaeqlkttrnayiqkylrnrDTMMSLLKTVVIVLGAFIICWTPGLVLL 387
NP_001004502 224 -------------------------------------------hssgqrrnrDTMMSLLKTVVIVLGAFIVCWTPGLVIL 260 zebrafish
Q9HBW0       225 -------------------------------------------hvschpryrETTLSLVKTVVIILGAFVVCWTPGQVVL 261 human
Q9UBY5       223 -------------------------------------------htsgsisrrRTPMKLMKTVMTVLGAFVVCWTPGLVVL 259 human

Feature 1                       ## ##                         
4Z34_A       388 LLDvccp-qcdVLAYEKFFLLLAEFNSAMNPIIYSYRDkeMSATF 431
NP_001004502 261 LLDvvca-ncnVLTYEKFFLLLAEFNSAMNPIIYSYRDkeMSITF 304 zebrafish
Q9HBW0       262 LLDglgcescnVLAVEKYFLLLAEANSLVNAAVYSCRDaeMRRTF 306 human
Q9UBY5       260 LLDglncrqcgVQHVKRWFLLLALLNSVVNPIIYSYKDedMYGTM 304 human

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