2XRP,4ATU,2BQQ,1MJD,5IOI,5IO9,5IN7,5IKC


Conserved Protein Domain Family
DCX1_DCX
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cd16112: DCX1_DCX 
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Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX)
DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.
Links
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Statistics
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PSSM-Id: 340529
Aligned: 13 rows
Threshold Bit Score: 169.325
Created: 30-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:tubulin binding sites [polypeptide binding site]
Evidence:
  • Comment: DCX binds the corner of four tubulin dimers and stabilizes both lateral and longitudinal lattice contacts.
  • Comment:Mutations in N- and C- terminal of DCX domain cause severe neuronal migration disorders in humans.
  • Structure:2XRP; Homo sapiens doublecortin repeat in complex with mammalian tubulin, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #          ###     #    ## #       #       ### ##  #                          # 
2XRP_I         6 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 85  human
NP_989666     51 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 130 chicken
4ATU_I        64 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 143 human
2BQQ_A        14 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 93  human
1MJD_A        14 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 93  human
XP_006003670  51 KAKKVRFYRNGDRYFKGIVYAVSADRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGTQKICSMDELEEGESYVCSSD 130 coelacanth
XP_007892144  54 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRTLsDNVNLPQGVRIIFNIDGSGKVGSLDELEEGGSYVCSSH 133 elephant shark
5IOI_A         8 MAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 87  human
5IO9_A         8 MAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 87  human
5IN7_A         6 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 85  human
5IKC_M         1 AAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSD 80  human
KPP77826      25 KAKKVRFYRNGDRYFKGIVYAVALDRFRTFDALLADLTRSLsDHINLPQGVRFIFTIDGSRKITSMDELEEGESYVCASE 104 Asian bonytongue
XP_018085346  51 KAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLsDNINLPQGVRYIYTIDGMNKISSMDELEEGESYVCSSD 130 African clawed ...

Feature 1                 
2XRP_I        86 NFFKKVEYT 94  human
NP_989666    131 NFFKKVEYT 139 chicken
4ATU_I       144 NFFKKVEYT 152 human
2BQQ_A        94 NFFDDVEYT 102 human
1MJD_A        94 NFFKKVEYT 102 human
XP_006003670 131 NFFKKVDYT 139 coelacanth
XP_007892144 134 DIFKKVDYT 142 elephant shark
5IOI_A        88 NFFDDVEYT 96  human
5IO9_A        88 NFFDDVEYT 96  human
5IN7_A        86 NFFDDVEYT 94  human
5IKC_M        81 NFFKKVEYT 89  human
KPP77826     105 NYYKKVDYT 113 Asian bonytongue
XP_018085346 131 NFFKKLEYT 139 African clawed frog

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