pfam11725: AvrE (this model, PSSM-Id:338078 is obsolete and has been replaced by 463332)
Pathogenicity factor
This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system. The family is long and carries a number of predicted functional regions, including in Erwinia stewartii, an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localization signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas. A double beta-propeller structure is found towards the N-terminus.
Jiyao W et al.(2023). "The conserved domain database in 2023.",