cd16704: RING-HC_RNF20_like (this model, PSSM-Id:319618 is obsolete and has been replaced by 438364)
RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
RNF20, also known as BRE1A, and RNF40, also known as BRE1B, are E3 ubiquitin-protein ligases that work together to form a heterodimeric complex that facilitate the K120 monoubiquitination of histone H2B (H2Bub1), a DNA damage-induced histone modification that is crucial for recruitment of the chromatin remodeler SNF2h to DNA double-strand break (DSB) damage sites. RNF20 regulates the cell cycle and differentiation of neural precursor cells (NPCs) and links histone H2B ubiquitylation with inflammation and inflammation-associated cancer. RNF40, also known as 95 kDa retinoblastoma-associated protein (RBP95), was identified as a novel leucine zipper retinoblastoma protein (pRb)-associated protein that may function as a regulation factor in the process of RNA polymerase II-mediated transcription and/or transcriptional processing. All family members contain a C3HC4-type RING-HC finger at its C-terminus.
Jiyao W et al.(2023). "The conserved domain database in 2023.",