Conserved Protein Domain Family
RING-H2_RNF103
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cd16473: RING-H2_RNF103 (this model, PSSM-Id:319387 is obsolete and has been replaced by 438136)
RING finger, H2 subclass, found in RING finger protein 103 (RNF103) and similar proteins
RNF103, also known as KF-1, or zinc finger protein 103 homolog (Zfp-103), is an endoplasmic reticulum (ER)-resident E3 ubiquitin-protein ligase that is widely expressed in many different organs, including brain, heart, kidney, spleen, and lung. It is involved in the ER-associated degradation (ERAD) pathway through interacting with components of the ERAD pathway, including Derlin-1 and VCP. RNF103 contains several hydrophobic regions at its N-terminal and middle regions, as well as a C-terminal C3H2C3-type RING-H2 finger.
Links
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Statistics
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PSSM-Id: 319387
Aligned: 20 rows
Threshold Bit Score: 83.4962
Created: 6-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding siteRING-H2 finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens AMFR (2LXP; also known as ubiquitin ligase GP78) binds two Zn2+ through its RING-H2 finger.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #              # #  #  #            #  #   
O00237       620 ECVVCLENFengcllmgLPCGHVFHQNCIVMWLag-grHCCPVCRWP 665 human
XP_002175986 183 LCVVCLENYqgndfiriLPCGHIFHAHCLDIWMtr-tfANCPLCKAD 228 Schizosaccharomyces japonicus yFS275
KFG53055     511 RCAICMDAYregaslryLPCFHTYHQACIDVWLsq--nGRCPICKEN 555 Toxoplasma gondii FOU
XP_011675876 332 ACPVCMDDYdeeaelrrLPCFHVYHKKCIDMWLnknqdPVCPICRVE 378 purple sea urchin
ELU09840     619 ECAICLESYksgvllcgLPCHHSFHHYCIMGWLtr-dnHCCPVCRWP 664 Capitella sp. I Grassle & Grassle, 1976
EFX88197     341 DCAICLDKYrvtvdvcgLPCGHQFHHDCIMVWLqr-dnHHCPICRWP 386 common water flea
XP_002739700 530 ECAICLESYdtesilcgLPCYHTYHHQCIVVWLhg--hHCCPICRWP 574 Saccoglossus kowalevskii
XP_004225505 489 SCSICLDNYkqhdhvcgLPCGHVFHHSCILSWLhs-dqHCCPICRWP 534 Ciona intestinalis
KFM79654     179 ECSICLESYrygeilcgLPCGHNFHMNCIMSWLsr-dnHCCPICRWP 224 Stegodyphus mimosarum
KDR08621     625 ECAVCLESYrwgtilcgLPCGHNYHQCCIMEWLgr-dnHHCPVCRWP 670 Zootermopsis nevadensis

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