Conserved Protein Domain Family
HRG
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pfam16954: HRG (this model, PSSM-Id:319027 is obsolete and has been replaced by 465321)
Haem-transporter, endosomal/lysosomal, haem-responsive gene
HRG1 is a family of conserved, membrane-bound permeases that reside in distinct intracellular compartments and bind and transport haem in metazoa. These proteins carry four transmembrane domains, 4xTMs, modelled here in two pairs, the two N-terminal and the two more C-terminal.
Links
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Statistics
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PSSM-Id: 319027
Aligned: 41 rows
Threshold Bit Score: 27.2805
Created: 31-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5ZHU0        72 LRFFLFIGILFSALSVVGFCTFLVLAITQHQ-------------SLT-----------------D-PRSYYLSCVWSFIS 120 chicken
EFX85573      77 lRNIQLLAFLLTDISIAVFAWYLFYAAYYKI-------------PMV-----------------PvDNSAIVTSVWVFMT 126 common water flea
XP_003252283   8 lGLRAAYSGISSVAGFSIFLVWTVV--YRQPgtaam----gglaGVL--------------------------ALWVLVT 55  northern white-...
XP_002712714   8 lgLRAAYAGVSSVAGFSIFLVWTVV--YRQPataam----gglaGVL--------------------------ALWVLVT 55  rabbit
XP_003973669   6 IHISIAYASFGMLMGFSAFLTWNIA--YIQPwtaam----gglsGVL--------------------------ALWTLIT 53  torafugu
XP_003441586   6 tYMRIAYASFGTIVGFSAFLVWNFV--YNQPwtgam----gglsGVL--------------------------ALWTLIT 53  Nile tilapia
XP_002126841  10 LHCRIAYSLFGIAIGVSVFVIWLTV--FDNRketyatvtygglsGVL--------------------------AAWNLIL 61  vase tunicate
XP_002609567   8 LAFRISFAVLGTFVGLSAAVCWIQV--FKSYdtaaf----gvasGLT--------------------------AAVALTI 55  Florida lancelet
EFO22831       7 mKVRLFWPVIGIISGIIAGLCFAIV--YRNWsatvm----afisSIV--------------------------AVNLLFI 54  eye worm
XP_003108049  33 INVRIAYTICGIIIGLFWACVYIFAWKVNIQ-------------SVSlvimlflfqnwvalatcLvATSFAFETFFFYFS 99  Caenorhabditis ...

Q5ZHU0       121 LK------W 123 chicken
EFX85573     127 AK------W 129 common water flea
XP_003252283  56 HVmymqdyW 64  northern white-cheeked gibbon
XP_002712714  56 HImykqdyW 64  rabbit
XP_003973669  54 HVmylqdlW 62  torafugu
XP_003441586  54 HImylqdyW 62  Nile tilapia
XP_002126841  62 HImhyqdlW 70  vase tunicate
XP_002609567  56 hilyareqw 64  Florida lancelet
EFO22831      55 H-------W 56  eye worm
XP_003108049 100 IKkdtilkW 108 Caenorhabditis remanei
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