Conserved Protein Domain Family
FOXO-TAD
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pfam16676: FOXO-TAD (this model, PSSM-Id:318811 is obsolete and has been replaced by 435506)
Transactivation domain of FOXO protein family
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.
Links
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Statistics
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PSSM-Id: 318811
Aligned: 24 rows
Threshold Bit Score: 51.9013
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A3RK75       569 RLPSDLD-DM--LIDQLdvECDVERVLHDTLMD-G-DALDFNFDP 608 zebrafish
XP_006631437 574 RLPADLDlDI--FHGSL--DCDVESILLNDFMD-S-EEMDFNFDC 612 spotted gar
XP_014818623 369 RLPIDLDiDM--YMENL--ECDMDYIINSELMD-G-EGLDFNFEP 407 Philomachus pugnax
XP_003455269 661 RMAADLEmEN--VPNSL--DCDVDSILLNDFMD-T-ENMDFNFDG 699 Nile tilapia
XP_015687902 466 KLPNDLDvDM--YMEDL--QCDVDYIISTDLMD-G-EGLDFNFEP 504 Protobothrops mucrosquamatus
XP_004074149 562 RMSAHVEmEN--ASHSL--DCDVDSILLSDFMD-T-QNMDFNFDS 600 Japanese medaka
NP_001128604 641 RLQSELEmDV--HQSSL--DCDVESILLNDFMD-StEGMDFNFDG 680 zebrafish
ELK15655     466 KMPQDLDlDM--YLENL--ECDMDNII-SDLMNgG-EGLDFNFEP 504 black flying fox
XP_002433432 606 PLPHDLDlDLdaVQG-L--HCDVDQVIQHELNV-D-GNLDFNFDS 645 black-legged tick
XP_015789420 552 PLPNDLDlNMdsLQGGL--ECDVDQVIRHELSV-E-GNLDFNFES 592 two-spotted spider mite
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