Conserved Protein Domain Family
LYRIC

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pfam15686: LYRIC (this model, PSSM-Id:317989 is obsolete and has been replaced by 434858)
Lysine-rich CEACAM1 co-isolated protein family
LYRIC is a family of proteins found in eukaryotes. It is a type-1b membrane protein with a single transmembrane domain and localizes to the endoplasmic reticulum and the nuclear envelope. It is also found in the nucleolus, suggesting functional relationships between these two cellular compartments. It is found to be colocalized with tight junction proteins ZO-1 and occludin in polarised epithelial cells, suggesting that LYRIC is part of the tight junction complex. LYRIC has been shown to promote tumor cell migration and invasion by activating the transcription factor NF-kappaB.
Statistics
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PSSM-Id: 317989
Aligned: 14 rows
Threshold Bit Score: 331.406
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Z1W6         6 WQDELAQQAEEGSARLRELLSVGLGFLRTELGLDL--GLEPKRYPSWVILVgTGALGLLLLFLLgy-gWAAAC--AGARK 80  Norway rat
EDM16429     133 WQDELAQQAEEGSARLRELLSVGLGFLRTELGLDL--GLEPKRYPSWVILV-GTGALGLLLLFLlgygWAAAC--AGARK 207 Norway rat
XP_011607236   6 FHGFTLEKAEQLSGRLREVLSSGQAYMLTRFGVDL--GLDPDLYPTWIVLS-ATAVVLLLLLAL----SWAAV--RGAPL 76  torafugu
XP_003444226   5 lRGLALEKAELLSSHLKELLSSGQGYVRARFGVDL--GLKPELYPTWVILS-TVAAGLLLLLSLs---WAAVC--GGLLA 76  Nile tilapia
XP_007249403   3 atwraaaleqaelvsdrlrrlassglhflhnefgldlgvspelwpswailtavlvgllvavwwvvacggatrrkrrtgar 82  Mexican tetra
XP_005159661   5 WQALATQRAEYVSDRIRGLLSSGLDFLRAELGVDL--GIKPEKCPSWLILS-AALIGLLLLVVL------AAC--GRRKR 73  zebrafish
XP_012427396   6 WQEAAARWAEEAAARVRDALSGGLGLLRAELGLEL--GLDPQALPAWLALAvPAALGFVLLGLL----LAAAC--GGGLR 77  zebra finch
XP_008106595   7 WPESVARQAEEVSARLREVLSAGAGLLRTELGLELppALEPQRLPGWLLLLaTSLLPLLLLLVLl---WGLRCgrGGSAR 83  green anole
XP_017207032   5 WQEIASQHVEQITGYVRESLSTGLVYLKSELGIDL--GLNPDLCAPWLLLL-TAWAGLVLLLVL----WVSVC--RG-FS 74  zebrafish
XP_011483200   4 WKDAASQQVKLLARRLNEELSKGLGWLRSELGVDL--GLKPELIPPWAIVL-AACAGLLLMVAL----WASVC--RAVFK 74  Japanese medaka
Q9Z1W6        81 KR---RSPPRKREEV-------------TPptp--apED-----------------------------PAQLKNL-RSE- 111 Norway rat
EDM16429     208 KR---RSPPRKREEV-------------TPptp--apED-----------------------------PAQLKNL-RSE- 238 Norway rat
XP_011607236  77 LRk--TPASRADLRS-------------CEp------DK-----------------------------AGLAKPV-RAE- 104 torafugu
XP_003444226  77 GkkrgSPVTHGSSRS-------------SSsggggepLK-----------------------------AGFAKTA-KPE- 112 Nile tilapia
XP_007249403  83 enhvnvsgavsatdggktqpaksarteepkkknkkkasekqktqpngrtvtepreeikavqespkqatpppqkqsqkqqq 162 Mexican tetra
XP_005159661  74 RaapvTASPRSIAAA-------------APv------KT-----------------------------SAPPKTV-KTEp 104 zebrafish
XP_012427396  78 KkparSAAVRKGDEAvgagltagggpgkAA-------GP-----------------------------GPGQLNL-KGD- 119 zebra finch
XP_008106595  84 PrrlrRTTAEEEEED-------------EDe-----eEDddeeeeaaatpkaglarggggphkgppltGPAGLLL-KAD- 143 green anole
XP_017207032  75 KrlagTETGDSAEN------------------------------------------------------TGPAQPVkKAD- 99  zebrafish
XP_011483200  75 KrpavRPADDGAGIK-----------------------------------------------------QSVSKPV-KSD- 99  Japanese medaka
Q9Z1W6       112 -EQKKKNRKKLPEK--PKPNG-RT-VEIPeDEVVRTPRSIT-AKQP---------------------------------- 151 Norway rat
EDM16429     239 -EQKKKNRKKLPEK--PKPNGrTV-EIPE-DEVVRTPRSIT-AKQP---------------------------------- 278 Norway rat
XP_011607236 105 -EQRKRNKKKPPEKt-HQSNGqPGnVAPQ-RENPPGTVLKP-KEDK---------------------------------- 146 torafugu
XP_003444226 113 -EQKKKNKKKTVEKk-Sqsngq-pvtvAQ-EEVKVAEAVSK--------------------------------------- 149 Nile tilapia
XP_007249403 163 qppqkqqqppqkqqqppqkqqqqqqppqkqqqqpqqkqqqqqqpaqkqqlpppqkqqqqppqkqqqplqkqqqqqppqkq 242 Mexican tetra
XP_005159661 105 sEPKKKNKKKAADKqkAqangq-tvaePQ-EEIKVTGEKKK-APAPtptrapapaptrapapaptpasapapvpvpapkp 181 zebrafish
XP_012427396 120 -EQKKRNRKKLPERa-Arpngr-sfidVSeDEVIQTVRKDN-IKQP---------------------------------- 161 zebra finch
XP_008106595 144 -EQKKRNKKKAPEK--AgrlngqpaheISeEEITPTVRREN-LKQP---------------------------------- 185 green anole
XP_017207032 100 -EPKRRNRKKNAEKk-Aqrng--lavePQ-EEVKTADDQEL--------------------------------------- 135 zebrafish
XP_011483200 100 -EPKKK-KKKA-EKk-Aqpngr-avpePQeEEAIASEEIVPhHHQP---------------------------------- 140 Japanese medaka
Q9Z1W6       152 ----------PETDK--KNEKS---------KKNKKKSKSDAKAVQNSSRHDGKEVDE------------GAWETKISHR 198 Norway rat
EDM16429     279 ----------PETDK--KNEKS---------KKNKKKSKSDAKAVQNSSRHDGKEVDE------------GAWETKISHR 325 Norway rat
XP_011607236 147 ----------TLVQIvqNPVQV---------KKNKKKARTDVKPVQHVSTNDLKEPDE------------GAWETKVSHR 195 torafugu
XP_003444226 150 ----------LPAQI--KTEKKqevqapvqvKKNKKKNKTDVKPVQLLSSNDGKEPDD------------GVWETKVSNR 205 Nile tilapia
XP_007249403 243 qqqqqppqkpqqqppqqkqqqqpsppaddkakknkkkpkpEGKQGQNAS--DGKEPDE------------GAWETMVSNR 308 Mexican tetra
XP_005159661 182 kqkpaptpaqPPADT--KT------------KKNKKKAKPELKTAQDVSSTDGKEPDE------------GAWETKVSNR 235 zebrafish
XP_012427396 162 ----------VDTEK--KNEKS----------KKKKKSKGDSKTVQDSSRLDGKEVDE------------GAWETKISNR 207 zebra finch
XP_008106595 186 ----------SDVEK--KTEKS---------KKNKKKQRGDAKTVQDQSRADGKEADE------------GAWETKISNR 232 green anole
XP_017207032 136 ------------AEV--RADKG---------KKNKKKTKASAKEKKSSTSVDGKEPDEavgnmsvmvnlaGTWETKVSNR 192 zebrafish
XP_011483200 141 ----------PPPQG--KSEKTae------gKKSKKKPKQAAKETKIVTA-DGKEPEE------------GTWETKVSNK 189 Japanese medaka
Q9Z1W6       199 EKRQQRKRDKVLTD----SGSldSTiPGIENTITVTTEQLT-TASFPVGSKKNKGD-------ShlnvqvsnFKSGKGDS 266 Norway rat
EDM16429     326 EKRQQRKRDKVLTDsg-sLDS--TI-PGIENTITVTTEQLT-TASFPVGSKKNKGDshlnvqvSn-------FKSGKGDS 393 Norway rat
XP_011607236 196 EKKQQRRKDKGPEDsg-sPGG--------TAAPKPHVVTAL--------TKKNRGN-------Sd-------SRGAG--- 241 torafugu
XP_003444226 206 EKRqQRRKEKGPEDsg-gPGS--------VEASKTHVEATVpAAV----NKRNRGNhesf-----------hsrTTGKGD 261 Nile tilapia
XP_007249403 309 EKRqQRKKEKGPGEpg-sPVAg----------qHGGKQTAQpVVIapviTKKNKe-------------------SLNLKS 358 Mexican tetra
XP_005159661 236 EKRqQRKKEKGPGEssgsPESg----------dRASMKVEQpVVTatagNKKNKe-------------------SSRVKA 286 zebrafish
XP_012427396 208 EKRqQRKRDKVLND----GGSgesnlqgiENTVTVPIEQLMpTPSlpvgLRKNKGDallnaq-------insskPAKGES 276 zebra finch
XP_008106595 233 EKRqQRKRDKVLTD----TGPesni-samENSVSLSTEPLTsSASfsvgPRKNKGDtvlnvq-------vnnskSGKGDT 300 green anole
XP_017207032 193 EKRqQRRKDKAPDDesgsPVPsaa--sgaTEQLQTTLEEAEtTITsavsTPPVQrvv--------------evdPPEIEA 256 zebrafish
XP_011483200 190 EKReQRKKDKSSSDgsssPGGgntpvsvpPEQPKTTSAGIPaPTN----QKKKQ-E------------------SARVKP 246 Japanese medaka
Q9Z1W6       267 T-L-Q------VSSGLNENITVNGGGWSEKSVKLSSQLSAGEE-KWNSVPPaSAGKRKTEQSAWTQDPGDtnangkD--W 335 Norway rat
EDM16429     394 T-L-Q------VSSGLNENITVNGGGWSEKSVKLSSQLSAGEEkWNSVPPA-SAGKRKTEQSAWTQDPGD------TnaN 458 Norway rat
XP_011607236 242 --K-GstatraAPPGRKEQPSVNSGGRTDASVKTAEQMGAARSsVHTAAQF-SVSQKHQ--------TQA------A--W 301 torafugu
XP_003444226 262 A-A-SeavkdkVSSSWRKEPSVNGGGWNDMSLKIPGQMSTMEGnKWSaISAaTHYRAPPEpqpWAQESQAt-----A--W 332 Nile tilapia
XP_007249403 359 E-K-KeavitpAPANWNTMSSVNSGGWNEM-LKITPQANTSDNeKWS-VNMkKSGQRNSEpltRAQESDG------T--W 426 Mexican tetra
XP_005159661 287 S-K-GdaiiapVTSAWNDVNSVNGGGLTEVPVKQAIQSNALNNdKWS-AGKkTSGHKNREnstWKQESEG------P--L 355 zebrafish
XP_012427396 277 S-I-Pq-----VSPGLSESHTVNGGSWNEKSVKISSQIGVGEE-KWTsVPStAAGKRKTEtlaWGQDTGDangngkD--W 346 zebra finch
XP_008106595 301 T-LqQ------VPSGLNEGPTVNGGNWNEKPVKISPQINTSEE-KWTpV-SsAGGKRKNEtsaWGKDTGDngn-gkD--W 368 green anole
XP_017207032 257 TfV-QdpvipqVTPCWEEVLTVNGSGWSDLGLQLPSHMTSVQTeSWTsMTVpTE-RQTSEpsvWPQDMEG------S--W 326 zebrafish
XP_011483200 247 E-K-VeaavtpA--NSSEVVDA-AAAKGTLKVRGPSHNVPSKQaSWT--------ASIQPaplWRSGIDD------S--W 305 Japanese medaka
Q9Z1W6       336 -----GRNWSDRSI--FSGI-----------------------------GST-----------AEPVS-Qs--------- 358 Norway rat
EDM16429     459 gk-dwGRNWSDRSI--FSGI-----------------------------GST-----------AEPVSqS---------- 485 Norway rat
XP_011607236 302 ss-seGQMKSGTSPatFSAL-----------------------------GCD-----------ATEPP-S---------- 329 torafugu
XP_003444226 333 sg-idGRIKADLSPvsFSML-----------------------------GLN-----------TTdp------------- 358 Nile tilapia
XP_007249403 427 ta-mdGRIKPERNTvnFAML-----------------------------GLN-----------PSAGDp----------- 454 Mexican tetra
XP_005159661 356 tg-ldGRIKAEPNQvnLTML-----------------------------GLN-----------PSGGEtgs--------- 385 zebrafish
XP_012427396 347 gvslvGRPWKERSL--FTPIaawnvdarintseqnsasfssfgltpgvsGSN-----------SESVSq----------- 402 zebra finch
XP_008106595 369 gvslvGRTWGERTL--FPGI-----------------------------AWSgvdgrintpeqSSPSFsslglnpkvsgs 417 green anole
XP_017207032 327 tivdrPNI-----PvtFSGLp----------------------------------------------------------- 342 zebrafish
XP_011483200 306 tvidrPIQSAELNLvsLARL-----------------------------GVG-----------PAQPQ------------ 333 Japanese medaka
Q9Z1W6       359 ----------TTSDYQWDGSRNQphiDDEWSGLNGLSSADPSSDWNAPAEEWGNWVdEDR----ASLLKSQEPISND 421 Norway rat
EDM16429     486 ----------TTSDYQWDGSRNQphiDDEWSGLNGLSSADPSSDWNAPAEEWGNWV-DEDr---ASLLKSQEPISND 548 Norway rat
XP_011607236 330 ----------NPAERRGS----Q---YDEWSGFNRTSPADPSSDWYAPVEHWGNYE-GVSv--mAAPPVKQEPAPHV 386 torafugu
XP_003444226 359 --------isNSVDLQWASRPKV---DDEWSGFNGMAAADPSSDWNAPVEHWGNYe-ePPvlvtPAPVQKEQPVPNK 423 Nile tilapia
XP_007249403 455 ----------SADLGNWTH---V---DSEWSGINGLGSGDLGSDWNAPAEVWGNFe-ePKv---ETPAVRETPVSKP 511 Mexican tetra
XP_005159661 386 --------ksSIEIGKWDKTPVV---DSEWSSFNGLGSVDPSSDWNAPSELWDNFe--AKv---DASALKEIPVSKP 446 zebrafish
XP_012427396 403 ---------aGTSDFQWDLSHAQtpvDDEWSGLNGLSSADPSSDWNAPAEEWGNWvdeEKv---ASVPQREERsdtq 467 zebra finch
XP_008106595 418 ssepvsqpgtTDFQWDLNRNQAHvd--dEWSGLNGLSSADPTSDWNAPAEEWGNWveeEKs---PSIPQLEEGLSEA 489 green anole
XP_017207032 343 ----------AVPDLSWSAPPAVp-vDDEWSGIKS-SSADPSCDWNAPSEEWGNYieqQPv---SAAPL-EQPGPEV 403 zebrafish
XP_011483200 334 ----------SVSSLSWVSQPRV---EDEWSGING-ASSDPSSDWNAPSEAWGNYe-ePTt---ETPLAQEKPLPES 392 Japanese medaka
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