Conserved Protein Domain Family
Mtf2_C
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pfam14061: Mtf2_C (this model, PSSM-Id:316574 is obsolete and has been replaced by 464077)
Polycomb-like MTF2 factor 2
Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.
Links
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Statistics
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PSSM-Id: 316574
Aligned: 12 rows
Threshold Bit Score: 105.528
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q16TK7         202 VGTDLQSSLNLYFGAA-HRILSGERFVIKGRR-VSVSGK---VQYLIEWEGC 248  yellow fever mosquito
3_pfamImport     1 SMEHLRASVNSYFGAE-GRLACGEKYTVLARR-VTPDGK---VQYLVQWEGF 47  
11_pfamImport    1 SFCDLKSSVNTYFGAA-NRIASGEQFSVLARR-VSPEGK---AQYLIEWEGL 47  
9_pfamImport     1 DSSHLHSSISSYFGIA-GRLTNGERYQVLARR-VTPQGT---VQYLLEWEGA 47  
7_pfamImport     1 SLSHLKSSITNYFGAA-GRLACGEKYQVLARR-VTPEGK---VQYLVEWEGT 47  
XP_009697845   123 QLNHLKNSITSYFGAA-GRIACGEKYRVLARR-VTLDGK---VQYLVEWEGA 169  red-legged seriema
XP_016838546   823 SMDDLKSSVNMYFGAA-NRIASGEKFMVRAKR-SGPNGR---AQYLIEWEGP 869  jewel wasp
XP_011168675   785 SLDDLKSSVNIYFGAA-NRIAAGEKFVIKAKR-IGPNGQ---IQYLIEWEGL 831  red fire ant
EEZ97202       669 NMDDLKSSVNIYFGAA-NRIAAGERFAVKAKR-VGPSGK---LEFLIEWEGP 715  red flour beetle
XP_002016386   986 SILDLKKSVNKYFGGAmNRIDSGEPFAIRAKR-RTGNGQ---VQYLVEWGGD 1033 Drosophila persimilis
XP_002062814  1040 sMLDLKQSVNKYFGGAiNRIDAGESFAIRAKR-RMGNGQ---VQYLVEWTNG 1087 Drosophila willistoni
XP_002130960   648 aHEDLRKNIARYFGPE-GRIACGERYRVLAKRqVSMKGNpphTEYLIEWEGY 698  vase tunicate
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