1WGS,2BUD,2LRQ,4QQG,2EFI


Conserved Protein Domain Family
Tudor-knot

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pfam11717: Tudor-knot (this model, PSSM-Id:314560 is obsolete and has been replaced by 432022)
Click on image for an interactive view with Cn3D
RNA binding activity-knot of a chromodomain
This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding.
Statistics
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PSSM-Id: 314560
Aligned: 47 rows
Threshold Bit Score: 36.3946
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WGS_A         13 VEIGE----TYLCRRp--------DSTWHSAEVIQSRVn---dQEGR----------------EEFYVHYVGFNRRLDEW 61   house mouse
Q9U3C3         52 KVVAV----IIHIDF---------RKPPQEVRTNNYKSienheQGAKe---------------LMYYVHYEELDRRNDEW 103  Caenorhabditi...
Q16W87        570 IEVGD----KLKVYYd-------eQKVTYEAKVIEIAI-----QEGS----------------PIYLVHYTGWNTRYDEW 617  yellow fever ...
Q5U8N1          7 FKINE----KVLCHKhe-----dpEGSYREARILETRE-----HNGN----------------TEYYVRYTEYNKRLDEW 56   Entamoeba his...
Q4UHT8         47 REIFSqqfpTAYPMEyelwgkdlmHNTWRRCTVVHARPv----DPNKeipll-------kpneYDYYIHWLGLDRRLDCW 115  Theileria ann...
Q5CX42        103 RVVGW----KLYG-----------TQVTHLSHLVNKKTgg--nKQNSlikvssssnesqikedYEFYVHFRGLNRRLDRW 165  Cryptosporidi...
2EFI_A         18 FQEGE----RVLCFH---------GPLLYEAKCVKVAI-----KDKQ----------------VKYFIHYSGWNKNWDEW 63   human
XP_321270       7 FTEGE----KVLCFH---------GPLLYEAKLLRCAMm----KEKQ----------------VKYLVHYAGWNKNWDEW 53   Anopheles gam...
XP_013877535  797 sVTGT----KVRVKYgr-----gkTQKIYEAHIKKTDV-----DNGE----------------QFYLVHYYGWNVRYDEW 846  Austrofundulu...
CCD75233       79 yEPGE----KLLCFH---------GPLMYEAKCLDVKV-----KEDG----------------VMYFVHYQGWNKNWDEW 124  Schistosoma m...
1WGS_A         62 VDKNRLAL 69   house mouse
Q9U3C3        104 ITLDKILV 111  Caenorhabditis elegans
Q16W87        618 VRKERVAE 625  yellow fever mosquito
Q5U8N1         57 TAANNIIR 64   Entamoeba histolytica
Q4UHT8        116 LTIENIRT 123  Theileria annulata
Q5CX42        166 VKGKDIKL 173  Cryptosporidium parvum
2EFI_A         64 VPESRVLK 71   human
XP_321270      54 VPESRVLK 61   Anopheles gambiae str. PEST
XP_013877535  847 VKADRIIw 854  Austrofundulus limnaeus
CCD75233      125 VTDKRMfk 132  Schistosoma mansoni
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