Conserved Protein Domain Family
Lge1
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pfam11488: Lge1 (this model, PSSM-Id:314408 is obsolete and has been replaced by 431907)
Transcriptional regulatory protein LGE1
This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1.
Links
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Statistics
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PSSM-Id: 314408
Aligned: 32 rows
Threshold Bit Score: 65.3419
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6CHN9        248 P-VVgtpkthtnqayqeaHFylgseTTVSRAsepyhikTAQTEGIQKRLTELEAFNQALEIL---------EAKKRKLEG 317 Yarrowia lipol...
Q16XG9        296 P-TVptvvta----------------------tvpvtaVASSSHVPSSTQLIKPHPVPISIVgrrrggkilKTGVVKKQK 352 yellow fever m...
25_pfamImport   2 PlFIdqperpeskttdgiEL-----FEDGRLssrykaiAAKTKMIEQVYQQDCETFAMVVKM------------LVEKDP 64 
Q0IIH2        194 PlFIdhpvepesnatdgiEL-----FEDSQLtsrskaiATKTKEIEQVYRQDCETFGMVVKM------------LIEKDP 256 cattle
12_pfamImport   2 GlYSdqpgeaetnvtestEL-----SEDKQNtersksiSSKIKEIEQVYRQDCETFGMVVKM------------LIDKDP 64 
15_pfamImport   2 PlYAehheetvanitgdnEL-----FEDTQRvrrakaiAAKTTEIEQVYKQDCETFGAVVKM------------LIEKDP 64 
26_pfamImport   2 PlYIeqteetdanltdstEL-----YEDSHLlsrakaiAAKTKEIEQVYRQDCETFGMVVKM------------LIDKDP 64 
18_pfamImport   2 PlYVeqteetetnvtdntEL-----YEDNQLlcrskaiATKTKEIEQVYRQDCETFGMVVKM------------LIDKDP 64 
17_pfamImport   2 PvFIdqteepesnttdgtEL-----CKDSQLssrskaiASKSKEIEQAYRQDFETFGMVVKM------------LVEKEP 64 
XP_002614565  166 P-WV--------------AI-----MRLGD--------GKSAARVNAAANELHTMNQKLSEL---------QAERMKLAS 208 Clavispora lus...

Q6CHN9        318 EYASIETDVVREGVRAEVTG------HA--LEVLNS 345 Yarrowia lipolytica
Q16XG9        353 PMEESFAETPNDAWNLYLQEvkkyknAScdADSKTR 388 yellow fever mosquito
25_pfamImport  65 SLEKPIQFALRQNLY-EMGQ------RC--VEELKH 91 
Q0IIH2        257 SLEKSIQFALRQNLH-EIGE------RC--VEELKH 283 cattle
12_pfamImport  65 SLEKCVQFALRQNLH-EIGE------RC--IEELKH 91 
15_pfamImport  65 SLEKSIQFSLRQNLH-EIGE------RC--IEELKH 91 
26_pfamImport  65 SLEKSIQFALRQNLH-EI------------------ 81 
18_pfamImport  65 SLEKSIQFALRQNLH-EIGE------RC--IEELKH 91 
17_pfamImport  65 SLENSIQFALRQNLQ-EMGE------RC--VEELKR 91 
XP_002614565  209 SLATLEVYAQRDALSVSVSA------EK--LDEFVY 236 Clavispora lusitaniae ATCC 42720
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