1Z9E


Conserved Protein Domain Family
LEDGF

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pfam11467: LEDGF (this model, PSSM-Id:314400 is obsolete and has been replaced by 463284)
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Lens epithelium-derived growth factor (LEDGF)
LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.
Statistics
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PSSM-Id: 314400
Aligned: 36 rows
Threshold Bit Score: 90.713
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1Z9E_A          5 DSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASL--QVTMQQAQKHTEMITTLK----KIRRFKVSQVIMEKSTMLYNK 78   human
OCA49057      501 EEKLQKLHSEIKFALKVDNPDIQKCLDALEELGGL--QVTSQILQKNTDVVATLK----KIRRYKANQSVMDKAAEVYSR 574  western clawe...
EKC21201      554 EGKLSAMDKEIKLCVQRDSTDVDKCLAIMEDLDAL--PVNQVMLKKNPDIMKTIKmvgsQLRKYKGSEKIRLKAEVIYHK 631  Pacific oyster
XP_011673625  523 EEKIENFHVNLKQSLALDNPEPARSLQIMANIDQImdRLTPSLLKKHVDFVQTIK----KVRKFKSSDAVRKKAEYLYNK 598  purple sea ur...
GAA28938      533 EARLLLIDRSIKSSLVRDHEDISTCVDRLEMLDRI--QISLPVLAKCWIVVETIR----KCRRYKRSMEVKIAAQKVFNK 606  Clonorchis si...
XP_003382928  780 vEALQAYNYNLKVSLIVGSAEPQKALKNLRGLMDY--HFSASDIVQVKDLVVTLR----KVRRYKGNSRVRSKANEVYNK 853  Amphimedon qu...
ELK19411       34 EEKLQKLHSEIKFALKVDNPDVKRCLNALEELGTL--QVTSHILQKNTDVVATLK----KIRRYKANKEVMEKAAEVYTR 107  black flying fox
XP_006800491  311 gERLQKLHTDIKFALKVDNPDIERCLQALEELEAV--PVTSQILHKNAEVIATLK----KIRRYKASTAVMEKASDVYNK 384  Neolamprologu...
CAG07956      471 EEKVQKLHTDIKFALKVDNPDIERCLQALEELEAV--PVTSQILQRNAEVIATLK----KIRRYKASAAVMEKASDVYNK 544  spotted green...
XP_007233414  453 EEKLQKLHTDIKFALKVDNPDIEKCLQALEELGSV--QVTSQILQKNTDVITTLK----KIRRYKASNAVMEKATEIYNK 526  Mexican tetra
1Z9E_A         79 FKNMFLV---GEGDsVITQVLNKSLAEQRQH 106  human
OCA49057      575 IKARILG---PKLEsQQKTVQKVNTAEKDpe 602  western clawed frog
EKC21201      632 FKGFFLA---GDGElNSSIMEHHHHKKQNNK 659  Pacific oyster
XP_011673625  599 LKLVFLM---QDSEsAALLKREMENEAKKVA 626  purple sea urchin
GAA28938      607 FLQLYATadkCELDlANAELAKHQQRHIKQH 637  Clonorchis sinensis
XP_003382928  854 IKGLF-V---CDKDvSSKTVTDENNCVQDQs 880  Amphimedon queenslandica
ELK19411      108 LKSRVLG---PKIEaIQKAARTGAEKERTEA 135  black flying fox
XP_006800491  385 LKLRFV----GKAEvAAKPKTENKEPENDEe 411  Neolamprologus brichardi
CAG07956      545 LKLRFV----GKLDmAAKPKSEGKELEENEQ 571  spotted green pufferfish
XP_007233414  527 LKLQFV----GKVE-TNKAKPEEKEKDDKTE 552  Mexican tetra
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