pfam11404: Potassium_chann (this model, PSSM-Id:314363 is obsolete and has been replaced by 431870)
Potassium voltage-gated channel
Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons. Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation.
Jiyao W et al.(2023). "The conserved domain database in 2023.",