2AUH


Conserved Protein Domain Family
BPS
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pfam08947: BPS (this model, PSSM-Id:312490 is obsolete and has been replaced by 462644)
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BPS (Between PH and SH2)
The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor.
Links
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Statistics
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PSSM-Id: 312490
Aligned: 11 rows
Threshold Bit Score: 82.1957
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2AUH_B        10 SISENSLVAMDFSGQKS-RVIENPTEALSVAVEEGLAWRKKGSLRL 54  human
XP_016895106 277 SISENSLVAMDFSGQKS-RVIENPSEALSVAVEEGLSWRRKSCHRL 321 tongue sole
XP_003942889 366 SVSDNTLVAMDFSGHAG-RVIENPREALSVALEEAQAWRKKTNHRL 410 Bolivian squirrel monkey
XP_012954439 229 SISENSLVAMDFSGHRS-RIIENPMEVLSVAVEEGLAWRRRGCLRL 273 mallard
XP_015741352 357 SVSDSALVAMDFSGCTG-RVIENPSEVLTAVLEEAQAWRKKTTHRY 401 Japanese quail
XP_015217420 372 CVSEASLVAMDFSGKAGgRVIENPREAQSAEQEEGQAWRKKTALRC 417 spotted gar
XP_008293654 275 SVSENSLVAMDFSGRTG-RVIDNPVEAQSAALEEGQTWR-KRSQRM 318 bicolor damselfish
AAH21820      37 SVSENSLVAMDFSGEKS-RVIDNPTEALSVAVEEGLAWRKKGCLRL 81  house mouse
XP_004917759 282 SISENSLVAMDFSGQKS-RVIENPTEALSIALQEGLLWRRKSSGRI 326 western clawed frog
NP_001102563 266 SVSENSLVAMDFSGQIG-RVIDNPAEAQSAALEEGHAWRKRST-RM 309 Norway rat
XP_014329009 335 SESENSLVAMDFTGKAGgRIIENPTEAQNAEQEEAQAWRKRETLRF 380 southern platyfish
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