Conserved Protein Domain Family
CathepsinC_exc
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pfam08773: CathepsinC_exc (this model, PSSM-Id:312344 is obsolete and has been replaced by 462598)
Cathepsin C exclusion domain
Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini. It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor.
Links
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Statistics
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PSSM-Id: 312344
Aligned: 31 rows
Threshold Bit Score: 144.34
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A0E8K5        15 LPVHCVRHQIV-GKWQLEFTE----PqikGSG-PLTCGHNVPDNERTSQvagqntfvktsT------------HEVILTA 76  Paramecium tetr...
A0DDP2        27 LPVHCVRHQIV-GKWQLQFTE----PqikGSG-PLTCGHNVPDNERTSQfagqntfqqafT------------HEVVLTA 88  Paramecium tetr...
A0E1S5        19 LPVHCLRHQIV-GKWKMEVSD----VqlrGVG-AVPCGHHVPDTQHSSYkagwedfrasdS------------FELTLGN 80  Paramecium tetr...
A0DZB1        19 LPVHCMKHQIT-GKWKMEVSQ----TklkGMG-AVPCGHHVPDSQQSSYqagfddfkavdT------------FEVNLSN 80  Paramecium tetr...
XP_009011590  23 TPVSCMYEDIR-GKWVFYVGN----G---GYDnNINCSTMGYEVSKILF-----------Q------------YKLELKY 71  Helobdella robusta
XP_002669412  24 IPVHCLFHQVF-GDWTFYRTS----TsfsNDVvHNTCALTNPLPNVNVD-----------T------------IKLRLLA 75  Naegleria grube...
XP_002670638  32 LPVHCLYNSTApGVWEFELTD----QnmsGDDvAAKCD--IRAPIQATR-----------T------------MKVYLQM 82  Naegleria grube...
XP_001023356  24 LPVHCVRSQIT-GKWLLKEGK----VlasSNNkPVSCGHQIPDKAESSN-----------SamggvltevereYEVFLDE 87  Tetrahymena the...
XP_004345515  25 IPVHCLYDQIV-GTWRFDMGA----N---NGDnSLVCND---DTFNPVK-----------S------------LHLRFAE 70  Capsaspora owcz...
XP_004031352  24 LPIHCLKNQVT-GYWILQRGKieatN---NERkMVSCGHQSPDNENTSY-----------KalngkldvveneEIIKINP 88  Ichthyophthiriu...

A0E8K5        77 KNNVVQKk-K-LQGKWTMVYDEGFEVDFSK-----YKCFAFSKYKTNY--S-G------AYSYCGETLIGWYQN--TETN 138 Paramecium tetr...
A0DDP2        89 KNNVVLKk-K-LQGKWTMVYDEGFEVDFMH-----YKCFAFSKYKTNY--S-G------AYSYCGETLVGWYQN--TKTN 150 Paramecium tetr...
A0E1S5        81 DYTVTDKdrK-QSGSWTMVYDEGFEVEHNG-----VKYFAFSKYEPNG--V-D------YKSLCGETLIGWYNN--QKTG 143 Paramecium tetr...
A0DZB1        81 DYSVQDKerK-TSGQWTMVYDEGFEVEHNG-----VKYFAFSKYAPNG--S-D------YKSYCGETLIGWYNN--LKTG 143 Paramecium tetr...
XP_009011590  72 PNIVIDEf-N-NEGTWTMIYDEGFEVTIHN-----RKFFAFSKFTGNM--F-N------STSFCNETFPGWSHD--VFGR 133 Helobdella robusta
XP_002669412  76 PDVVYDEq-G-NEGFWTLIYDQGFEVVINK-----QKYFAFFNYTQQG--K-V------VTSNCGQTFTGWYHDagIAVK 139 Naegleria grube...
XP_002670638  83 PDIAIDEk-G-NTGFFTLVYDQGFEVVVGG-----NKYWAFFNYTTAG--K-DsqgndiIISNCDRTFTGWYHEakVKAK 152 Naegleria grube...
XP_001023356  88 DFTVRGKe-G--KGRWTLVYDEGWEIEYNG-----VKYTHFFKYAKDD--SgQ------YKSVCSQTLVGWFNH--IQKK 149 Tetrahymena the...
XP_004345515  71 PNIVYNSs-GiQVADWTMIYDEGISVRMMDgakftQLFFAFFPYTVDPisG-N------VTSFCNETVLSTYHDapYGSG 142 Capsaspora owcz...
XP_004031352  89 DFTVSGDk-G--TGKWTLIYDEGWEIDYNN-----TKYTHFFKYYNQN--G-N------YKTDCDNTLVGWFNS--YSVS 149 Ichthyophthiriu...

A0E8K5       139 E----RGCYR 144 Paramecium tetraurelia
A0DDP2       151 E----RGCYR 156 Paramecium tetraurelia
A0E1S5       144 E----KGCYR 149 Paramecium tetraurelia
A0DZB1       144 E----KGCYR 149 Paramecium tetraurelia
XP_009011590 134 D----WACYY 139 Helobdella robusta
XP_002669412 140 K----FGCFR 145 Naegleria gruberi strain NEG-M
XP_002670638 153 S----WGCYR 158 Naegleria gruberi strain NEG-M
XP_001023356 150 S----RGCSQ 155 Tetrahymena thermophila SB210
XP_004345515 143 QlplgWGCFK 152 Capsaspora owczarzaki ATCC 30864
XP_004031352 150 Q----RGCSI 155 Ichthyophthirius multifiliis
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